Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery

Hybrid Lipid/Polymer Nanoparticles to Tackle the Cystic Fibrosis Mucus Barrier in siRNA Delivery to the Lungs: Does PEGylation Make the Difference?

(2022) Gemma Conte et al.   ACS Applied Materials & Interfaces

Inhaled RNA Therapeutics for Obstructive Airway Diseases: Recent Advances and Future Prospects

(2021) You Xu et al.   Pharmaceutics

From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?

(2021) Jacob E. Michalski et al.   Translational Research

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery

(2020) Yulia Eygeris et al.   NANO LETTERS

T-cell targeted pulmonary siRNA delivery for the treatment of asthma

(2020) Tobias W. M. Keil et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Inhaled Liposomal Antimicrobial Delivery in Lung Infections

(2020) Matteo Bassetti et al.   DRUGS

Chronic respiratory diseases: a global view

(2020) Wassim W Labaki et al.   Lancet Respiratory Medicine

A reprieve from hemophilia A, but for how long?

(2020) Cormac Sheridan   NATURE BIOTECHNOLOGY

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Poly(lactide-co-glycolide) Nanoparticles for Prolonged Therapeutic Efficacy of Esculentin-1a-Derived Antimicrobial Peptides against Pseudomonas aeruginosa Lung Infection: in Vitro and in Vivo Studies

(2019) Bruno Casciaro et al.   BIOMACROMOLECULES

Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics

(2019) Jayesh A. Kulkarni et al.   ACCOUNTS OF CHEMICAL RESEARCH

Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles

(2019) Tobias W.M. Keil et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

Progress in formulation development and sterilisation of freeze-dried oligodeoxynucleotide-loaded gelatine nanoparticles

(2018) Katharina J. Geh et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Use of Precision-Cut Lung Slices as an Ex Vivo Tool for Evaluating Viruses and Viral Vectors for Gene and Oncolytic Therapy

(2018) María C. Rosales Gerpe et al.   Molecular Therapy-Methods & Clinical Development

siRNA-mediated protein knockdown in precision-cut lung slices

(2018) Mitchel J.R. Ruigrok et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Inhalable siRNA-loaded nano-embedded microparticles engineered using microfluidics and spray drying

(2017) Monica Agnoletti et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A new combination therapy for asthma using dual-function dexamethasone-conjugated polyethylenimine and vitamin D binding protein siRNA

(2017) M Choi et al.   GENE THERAPY

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

(2016) Paul F Mercer et al.   THORAX

Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance

(2015) Steven K. Jones et al.   BIOMACROMOLECULES

Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures

(2015) Franziska E. Uhl et al.   EUROPEAN RESPIRATORY JOURNAL

Revisiting pulmonary acinar particle transport: convection, sedimentation, diffusion, and their interplay

(2015) Philipp Hofemeier et al.   JOURNAL OF APPLIED PHYSIOLOGY

Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations

(2015) Daniel Weinbuch et al.   PHARMACEUTICAL RESEARCH

siRNA Delivery to the lung: What's new?

(2014) Olivia M. Merkel et al.   ADVANCED DRUG DELIVERY REVIEWS

Influence of Oligospermines Architecture on Their Suitability for siRNA Delivery

(2014) Maha Elsayed et al.   BIOMACROMOLECULES

Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity

(2013) Ruibin Li et al.   ACS Nano

Comprehensive Analysis of the Effects of CdSe Quantum Dot Size, Surface Charge, and Functionalization on Primary Human Lung Cells

(2012) Amber Nagy et al.   ACS Nano

Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers

(2012) Mengyao Zheng et al.   BIOMATERIALS

Conception, preparation and properties of functional carrier particles for pulmonary drug delivery

(2012) Marcin Odziomek et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

(2012) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Protein−Nanoparticle Interactions: Opportunities and Challenges

(2011) Morteza Mahmoudi et al.   CHEMICAL REVIEWS

Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA

(2011) Ditte Krohn Jensen et al.   JOURNAL OF CONTROLLED RELEASE

Polymer-related off-target effects in non-viral siRNA delivery

(2010) Olivia M. Merkel et al.   BIOMATERIALS

Triazine Dendrimers as Nonviral Vectors for in Vitro and in Vivo RNAi: The Effects of Peripheral Groups and Core Structure on Biological Activity

(2010) Olivia M. Merkel et al.   MOLECULAR PHARMACEUTICS

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Inhalable siRNA: Potential as a Therapeutic Agent in the Lungs

(2008) Niamh Durcan et al.   MOLECULAR PHARMACEUTICS