Low-dimensional compounds containing bioactive ligands. Part VI: Synthesis, structures, in vitro DNA binding, antimicrobial and anticancer properties of first row transition metal complexes with 5-chloro-quinolin-8-ol

A series of new 3d metal complexes with 5-chloro-quinolin-8-ol (CIQ), [Mn(ClQ)(2)] (1), [Fe(ClQ)(3)] (2), [Co(ClQ)(2)(H2O)(2)] (3), [Ni(ClQ)(2)(H2O)(2)] (4), [Cu(ClQ)(2)] (5), Izn(ClQ)(2)(H2O)(2)] (6), [Mn(ClQ)(3)]center dot DMF (7) and [Co(ClQ)(3)]center dot DMF center dot(EtOH)(0.35) (8) (DMF = N,N-dimethylformamide), has been synthesized and characterized by elemental analysis, IR spectroscopy and TG-DTA thermal analysis. X-ray structure analysis of 7 and 8 revealed that these molecular complexes contain three chelate ClQ molecules coordinated to the central atoms in a deformed octahedral geometry and free space between the complex units is filled by solvated DMF and ethanol molecules. Antimicrobial activity of 1-6 was tested by determining the minimum inhibitory concentration and minimum microbicidal concentration against 12 strains of bacteria and 5 strains of fungi. The intensity of antimicrobial action varies depending on the group of microorganism and can be sorted: 1 > ClQ> 6 > 3/4 > 2 > 5. Complexes 1-6 exhibit high cytotoxic activity against MDA-MB, HCT-116 and A549 cancer cell lines. Among them, complex 2 is significantly more cytotoxic against MDA-MB cells than cisplatin at all tested concentrations and is not cytotoxic against control mesenchymal stem cells indicating that this complex seems to be a good candidate for future pharmacological evaluation. Interaction of 1-6 with DNA was investigated using UV-VIS spectroscopy, fluorescence spectroscopy and agarose gel electrophoresis. The binding studies indicate that 1-6 can interact with CT-DNA through intercalation; complex 2 has the highest binding affinity. Moreover, complexes 1-6 inhibit the catalytic activity of topoisomerase I. (C) 2015 Elsevier Inc. All rights reserved.