V. cholerae MakA is a cholesterol-binding pore-forming toxin that induces non-canonical autophagy

ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy

(2022) Yue Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae

(2022) Aftab Nadeem et al.   eLife

A Genomic Island of Vibrio cholerae Encodes a Three-Component Cytotoxin with Monomer and Protomer Forms Structurally Similar to Alpha-Pore-Forming Toxins

(2022) Alfa Herrera et al.   JOURNAL OF BACTERIOLOGY

Characterisation of a tripartite α-pore forming toxin from Serratia marcescens

(2021) Alicia M. Churchill-Angus et al.   Scientific Reports

Macrophages target Listeria monocytogenes by two discrete non-canonical autophagy pathways

(2021) Alexander Gluschko et al.   Autophagy

A tripartite cytolytic toxin formed by Vibrio cholerae proteins with flagellum-facilitated secretion

(2021) Aftab Nadeem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation

(2021) Rachel Ulferts et al.   Cell Reports

Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

(2020) Tao Ni et al.   Science Advances

All major cholesterol-dependent cytolysins use glycans as cellular receptors

(2020) Lucy K. Shewell et al.   Science Advances

LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

(2020) Shuhei Nakamura et al.   NATURE CELL BIOLOGY

LC3-associated phagocytosis at a glance

(2019) Bradlee L. Heckmann et al.   JOURNAL OF CELL SCIENCE

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

(2019) Yue Xu et al.   CELL

Autophagy-Independent Functions of the Autophagy Machinery

(2019) Lorenzo Galluzzi et al.   CELL

Identification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila

(2019) Jason S. Wilson et al.   Nature Communications

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cholesterol promotes Cytolysin A activity by stabilizing the intermediates during pore formation

(2018) Pradeep Sathyanarayana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival

(2018) Maja Radulovic et al.   EMBO JOURNAL

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

(2018) Anaïs Menny et al.   Nature Communications

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins

(2017) Aimin Yang et al.   eLife

The pH-Dependent Trigger in Diphtheria Toxin T Domain Comes with a Safety Latch

(2016) Mykola V. Rodnin et al.   BIOPHYSICAL JOURNAL

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Listeriolysin O Membrane Damaging Activity Involves Arc Formation and Lineaction -- Implication for Listeria monocytogenes Escape from Phagocytic Vacuole

(2016) Yi Ruan et al.   PLoS Pathogens

Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation

(2016) Courtney M. Boyd et al.   Scientific Reports

Secretory autophagy

(2015) Marisa Ponpuak et al.   CURRENT OPINION IN CELL BIOLOGY

Atomic structure of anthrax protective antigen pore elucidates toxin translocation

(2015) Jiansen Jiang et al.   NATURE

Pore-forming toxins: ancient, but never really out of fashion

(2015) Matteo Dal Peraro et al.   NATURE REVIEWS MICROBIOLOGY

The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration

(2015) Yong-Bo Hu et al.   Translational Neurodegeneration

Self and Nonself: How Autophagy Targets Mitochondria and Bacteria

(2014) Felix Randow et al.   Cell Host & Microbe

Mechanism of Tc toxin action revealed in molecular detail

(2014) Dominic Meusch et al.   NATURE

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity

(2014) Lucy K. Shewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ESCRT Machinery Is Required for Plasma Membrane Repair

(2014) A. J. Jimenez et al.   SCIENCE

Mechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair

(2014) Luana L. Scheffer et al.   Nature Communications

Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin

(2014) Carl Leung et al.   eLife

Structure of the NheA Component of the Nhe Toxin from Bacillus cereus: Implications for Function

(2013) Magdah Ganash et al.   PLoS One

Bacterial Subversion of Host Innate Immune Pathways

(2013) L. A. Baxt et al.   SCIENCE

Pathogenic Pore-Forming Proteins: Function and Host Response

(2012) Mirko Bischofberger et al.   Cell Host & Microbe

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation

(2012) A. Choy et al.   SCIENCE

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Membrane assembly of the cholesterol-dependent cytolysin pore complex

(2011) Eileen M. Hotze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface

(2010) A. J. Farrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of a cytolytic α-helical toxin pore reveals its assembly mechanism

(2009) Marcus Mueller et al.   NATURE

Pore formation: An ancient yet complex form of attack

(2008) Ioan Iacovache et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

X-ray crystal structure of the B component of Hemolysin BL fromBacillus cereus

(2008) Mahendra Madegowda et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS