Hyperactivation of the proteasome in Caenorhabditis elegans protects against proteotoxic stress and extends lifespan

26S proteasomes become stably activated upon heat shock when ubiquitination and protein degradation increase

(2022) Donghoon Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging and age‐related diseases: from mechanisms to therapeutic strategies

(2021) Zhe Li et al.   BIOGERONTOLOGY

Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans

(2021) Maria Sladowska et al.   PLOS BIOLOGY

The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates

(2020) Kirby Martinez-Fonts et al.   Nature Communications

cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases

(2020) Jordan J. S. VerPlank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein damage, ageing and age-related diseases

(2019) Anita Krisko et al.   Open Biology

26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

(2019) Jordan J. S. VerPlank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders

(2019) Evert Njomen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and Function of the 26S Proteasome

(2018) Jared A.M. Bard et al.   Annual Review of Biochemistry

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

C. elegans Development and Activity Test detects mammalian developmental neurotoxins

(2018) Piper Reid Hunt et al.   FOOD AND CHEMICAL TOXICOLOGY

Proteasome activation enhances stemness and lifespan of human mesenchymal stem cells

(2017) Marianna Kapetanou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inverse correlation between longevity and developmental rate among wild C. elegans strains

(2016) Yujin Lee et al.   Aging-US

Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways

(2016) Rachel Raynes et al.   MOLECULAR ASPECTS OF MEDICINE

Gates, Channels, and Switches: Elements of the Proteasome Machine

(2016) Daniel Finley et al.   TRENDS IN BIOCHEMICAL SCIENCES

Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation

(2016) Won Hoon Choi et al.   Nature Communications

20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans

(2015) Niki Chondrogianni et al.   FASEB JOURNAL

Measuring Food Intake and Nutrient Absorption in Caenorhabditis elegans

(2015) Rafael L. Gomez-Amaro et al.   GENETICS

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Measuring Food Intake and Nutrient Absorption in Caenorhabditis elegans

(2015) Rafael L. Gomez-Amaro et al.   GENETICS

Fasting: Molecular Mechanisms and Clinical Applications

(2014) Valter D. Longo et al.   Cell Metabolism

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

(2014) Isabel Saez et al.   CURRENT GENOMICS

Methodological considerations for heat shock of the nematode Caenorhabditis elegans

(2014) Shannin C. Zevian et al.   METHODS

The proteasome and the degradation of oxidized proteins: Part III—Redox regulation of the proteasomal system

(2014) Tobias Jung et al.   Redox Biology

Molecular Architecture and Assembly of the Eukaryotic Proteasome

(2013) Robert J. Tomko et al.   Annual Review of Biochemistry

Structural Biology of the Proteasome

(2013) Erik Kish-Trier et al.   Annual Review of Biophysics

Structural Insights into Proteasome Activation by the 19S Regulatory Particle

(2013) Aaron Ehlinger et al.   BIOCHEMISTRY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons

(2012) Natura Myeku et al.   NEUROSCIENCE LETTERS

Basic Caenorhabditis elegans Methods: Synchronization and Observation

(2012) Montserrat Porta-de-la-Riva et al.   Jove-Journal of Visualized Experiments

Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities

(2011) Utano Tomaru et al.   AMERICAN JOURNAL OF PATHOLOGY

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Dysfunction of the ubiquitin–proteasome system in the cerebellum of aging Ts65Dn mice

(2011) Daniela Necchi et al.   EXPERIMENTAL NEUROLOGY

Protein homeostasis and aging: The importance of exquisite quality control

(2010) Hiroshi Koga et al.   AGEING RESEARCH REVIEWS

Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

(2010) Qian Huang et al.   APOPTOSIS

Proteasome inhibition modeling nigral neuron degeneration in Parkinson’s disease

(2010) Wenjie Xie et al.   JOURNAL OF NEUROCHEMISTRY

Proteasome and oxidative phoshorylation changes may explain why aging is a risk factor for neurodegenerative disorders

(2010) Claus Zabel et al.   Journal of Proteomics

Regulation of the 26S Proteasome Complex During Oxidative Stress

(2010) X. Wang et al.   Science Signaling

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Measuring Caenorhabditis elegans Life Span on Solid Media

(2009) George L. Sutphin et al.   Jove-Journal of Visualized Experiments

Blm10 binds to pre-activated proteasome core particles with open gate conformation

(2008) Andrea Lehmann et al.   EMBO REPORTS

Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins

(2008) Balasubrahmanyam Medicherla et al.   JOURNAL OF CELL BIOLOGY

Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

(2008) L. Bedford et al.   JOURNAL OF NEUROSCIENCE

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

(2008) A. Tonoki et al.   MOLECULAR AND CELLULAR BIOLOGY

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

(2008) Hwan-Ching Tai et al.   NATURE REVIEWS NEUROSCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE