Article
Rheumatology
Sifan Wu, Xiufang Kong, Ying Sun, Xiaojuan Dai, Wensu Yu, Rongyi Chen, Lili Ma, Lindi Jiang
Summary: This study identified the role of FABP3 in vascular fibrosis in TAK and explored the underlying molecular mechanism. The expression of FABP3 was increased in the thickened adventitia of TAK patients and positively correlated with the serum expression of ECMs. FABP3 knockdown inhibited AAF proliferation and ECM production, while FABP3 overexpression enhanced these processes. Further analysis revealed that FABP3 upregulation promoted FAO and ATP production in AAFs. FABP3 and CACT were co-localized in the adventitia and bound to each other in AAFs. Etomoxir reversed the enhanced FAO, ATP production, AAF proliferation, and ECM production mediated by FABP3 upregulation. Treatment with curcumin reduced the level of serum FABP3 and inhibited vascular fibrosis by reducing FABP3-enhanced FAO in AAFs.
Article
Cardiac & Cardiovascular Systems
Austin Deets, Parag H. Joshi, Alvin Chandra, Kavisha Singh, Amit Khera, Salim S. Virani, Christie M. Ballantyne, James D. Otvos, Robin P. F. Dullaart, Eke G. Gruppen, Margery A. Connelly, Colby Ayers, Ann Marie Navar, Ambarish Pandey, John T. Wilkins, Anand Rohatgi
Summary: This study aimed to assess the association between levels of specific size-based HDL subspecies and atherosclerotic cardiovascular disease, and investigate their role in risk prediction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, Research & Experimental
Zihao Chang, Qiunan Zhang, Qian Hu, Yuqi Liu, Lanzhen Zhang, Runping Liu
Summary: The study shows that the total tannin fraction of Terminalia bellirica (TB-TF) can inhibit hepatocellular carcinoma growth, promote the polarization of tumor-associated macrophages towards an anti-tumor phenotype, increase T cell infiltration, and restore cytotoxic function of CD8+T cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Zakaria Mougin, Julia Huguet Herrero, Catherine Boileau, Carine Le Goff
Summary: Extracellular matrix (ECM) in the vascular wall is a dynamic structure composed of different molecules. Metalloproteases, including ADAMTS proteins, play a key role in maintaining ECM homeostasis. This review focuses on the potential role of ADAMTS proteins in the development of thoracic and abdominal aortic aneurysms, providing new insights on the involvement of the ADAMTS family in these pathologies.
Review
Immunology
Suowen Xu, Qing Rex Lyu, Iqra Ilyas, Xiao-Yu Tian, Jianping Weng
Summary: Atherosclerosis is a chronic disease characterized by lipid deposition, inflammation, and impaired inflammation resolution, leading to narrowing of blood vessels, hardening, and plaque formation. Recent evidence suggests that the vascular system can be viewed as a complex homeostatic system, similar to a mini-ecosystem, consisting of the vascular microenvironment and the interaction among different types of vascular cells. By studying the cellular components in the vascular wall and their impact on vascular homeostasis, structure, function, and atherosclerosis, we can gain insights into the pathogenesis and explore vascular-stabilizing strategies to prevent cardiovascular diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Wah Wah Aung, Chenyang Wang, Jia Xibei, Motoki Horii, Kie Mizumaki, Miyu Kano, Ai Okamura, Tadahiro Kobayashi, Takashi Matsushita
Summary: Tofacitinib showed significant improvement in fibrosis in a mouse model of systemic sclerosis by suppressing immune responses of T and B cells, proinflammatory cells, and macrophages, and reducing the expression of fibrotic cytokines and proteins.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Genetics & Heredity
David Freiholtz, Otto Bergman, Sailendra Pradhananga, Karin Lang, Flore-Anne Poujade, Carl Granath, Christian Olsson, Anders Franco-Cereceda, Pelin Sahlen, Per Eriksson, Hanna M. Bjorck
Summary: The fibrotic type of endothelial mesenchymal transition (EndMT) is implicated in the development of degenerative ascending aortic aneurysm (AscAA). This study identified SPP1 as a key gene in the signature of fibrotic EndMT in patients with degenerative AscAA. The study also implicated ETS1 as a potential regulator of SPP1 expression under inflammatory conditions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Chemistry, Multidisciplinary
Bo Zhang, Huining Wan, Xiyu Liu, Tao Yu, Yuan Yang, Yan Dai, Yaling Han, Kai Xu, Li Yang, Yunbing Wang, Xingdong Zhang
Summary: The authors developed a biomimetic nanoparticle coating stent through amyloid-like protein-assembly-mediated interfacial engineering. This stent promotes vascular healing through rapid endothelialization and inhibition of intimal hyperplasia, and exhibits better anticoagulant activity and immunomodulation.
Article
Cardiac & Cardiovascular Systems
Angela Lopez-Sainz, Laia Mila, Jose Rodriguez-Palomares, Javier Limeres, Chiara Granato, Lucia La Mura, Ana Sabate, Andrea Guala, Laura Gutierrez, Laura Galian-Gay, Augusto Sao-Aviles, Sergi Bellmunt, Rafael Rodriguez, Hug Cuellar-Calabria, Albert Roque, Ignacio Ferreira-Gonzalez, Artur Evangelista, Gisela Teixido-Tura
Summary: This study revealed that aortic branch aneurysms are present in approximately one-quarter of patients with MFS, are associated with patient age and aortic dilation, and independently predict the need for aortic surgery.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biology
Seham Mustafa
Summary: The study found that cooling induces relaxation in vascular smooth muscles and contraction in non-vascular smooth muscles, with responses inversely proportional to temperature. No relaxant or contractile substance was released from either type of smooth muscle during cooling.
JOURNAL OF THERMAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anastasia V. Poznyak, Vasily N. Sukhorukov, Ilya I. Eremin, Irina I. Nadelyaeva, Nikita A. Gutyrchik, Alexander N. Orekhov
Summary: Lipid metabolism disorders are involved in various diseases, including cardiovascular, metabolic, neurodegenerative diseases, and cancer. HDL, an important component of lipid metabolism, plays a significant role in vascular protection. Many studies have shown that low levels of HDL cholesterol are associated with increased cardiovascular risk. Therefore, HDL-C is considered a promising therapeutic target. This review discusses current and potential HDL-based therapeutic strategies.
Article
Biochemistry & Molecular Biology
Kouichi Miura, Naoshi Arai, Rie Goka, Naoki Morimoto, Shunji Watanabe, Norio Isoda, Hironori Yamamoto, Kazuhiko Kotani
Summary: The study found that oxHDL levels were significantly higher in NAFLD patients and increased as fibrosis progressed. These levels were independent of HDL cholesterol levels, and statin use did not affect oxHDL levels.
Article
Chemistry, Multidisciplinary
Yusen Qiao, Lei Yu, Peng Yang, Miao Chen, Haifu Sun, Lingjie Wang, Bangzhao Wu, Chun-do Oh, Huilin Yang, Jiaxiang Bai, Dechun Geng
Summary: A composite material called PCLA has been developed to regulate immune response in high-glucose inflammatory environments and promote bone regeneration and angiogenesis, which is of great significance for the healing of bone wounds in diabetic patients.
Article
Cell Biology
Zhu-Jun Shen, Ye-Chen Han, Mu-Wen Nie, Yi-Ning Wang, Ruo-Lan Xiang, Hong-Zhi Xie
Summary: Sepsis is the leading cause of death in hospital intensive care units. Recent studies have shown that variations in N-6-methyladenosine (m(6)A) levels in RNA transcripts can influence inflammatory responses. Our evaluation of m(6)A profiles in rat aortic mRNAs and lncRNAs after LPS-induced sepsis revealed significant decreases in global m(6)A levels and downregulated expression of key m(6)A writer complex members. Further analysis suggested that differentially m(6)A methylated mRNAs may affect key biological processes and inflammatory responses during sepsis.
Article
Clinical Neurology
Takao Hoshino, Kentaro Ishizuka, Sono Toi, Takafumi Mizuno, Ayako Nishimura, Shuntaro Takahashi, Sho Wako, Kazuo Kitagawa
Summary: This study found a close association between atherogenic dyslipidemia (AD) and residual vascular risk in stroke patients. Patients with AD were more likely to have intracranial artery stenosis and had a higher risk of major adverse cardiovascular events and ischemic stroke within 1 year. AD was predictive of major adverse cardiovascular events regardless of baseline low-density lipoprotein cholesterol (LDL-C) levels.
Article
Cardiac & Cardiovascular Systems
Florian Krackhardt, Magnus Jornten-Karlsson, Matthias Waliszewski, Mikael Knutsson, Anna Niklasson, Karl-Friedrich Appel, Ralf Degenhardt, Alexander Ghanem, Till Koehler, Marc-Alexander Ohlow, Carsten Tschoepe, Heinz Theres, Juergen vom Dahl, Bjorn W. Karlson, Lars S. Maier
Summary: This study evaluated the effectiveness of a patient support tool app in improving medication adherence and lifestyle changes in patients with acute coronary syndrome. Results showed that the app intervention significantly improved medication adherence compared to a control group. General improvements in health status and lifestyle changes were observed in both groups.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Mariann Gyongyosi, Pilar Alcaide, Folkert W. Asselbergs, Bianca J. J. M. Brundel, Giovanni G. Camici, Paula da Costa Martins, Peter Ferdinandy, Marianna Fontana, Henrique Girao, Massimiliano Gnecchi, Can Gollmann-Tepekoylu, Petra Kleinbongard, Thomas Krieg, Rosalinda Madonna, Melanie Paillard, Antonis Pantazis, Cinzia Perrino, Maurizio Pesce, Gabriele G. Schiattarella, Joost P. G. Sluijter, Sabine Steffens, Carsten Tschope, Sophie Van Linthout, Sean M. Davidson
Summary: Long COVID is a global non-communicable epidemic characterized by long-lasting multiorgan symptoms after SARS-CoV-2 infection has subsided. This scientific document aims to provide insight into the cardiovascular manifestations of long COVID and the possible causes and therapeutic options available. Imaging has shown evidence of chronic perimyocarditis, arterial wall inflammation, and microthrombosis in certain patient populations. Understanding the underlying cellular and molecular mechanisms is crucial for the development of effective treatment strategies. However, current biomarkers are not highly predictive for the presence or outcome of long COVID.
CARDIOVASCULAR RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
A. Hagendorff, A. Helfen, R. Brandt, E. Altiok, O. Breithardt, D. Haghi, J. Knierim, D. Lavall, N. Merke, C. Sinning, S. Stobe, C. Tschope, F. Knebel, S. Ewen
Summary: Currently, the diagnosis of HFpEF is based on echocardiographic parameters and clinical symptoms combined with natriuretic peptide levels. However, this diagnosis includes multiple pathophysiological entities, making it difficult to develop a uniform management plan. Therefore, a standardized echocardiographic workflow is necessary to characterize the underlying cardiac pathologies in patients with preserved ejection fraction and symptoms of heart failure.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Janine Poess, Christoph Sinning, Isabelle Schreiner, Christian Apfelbacher, Karl-Philipp Drewitz, Nadine Hoesler, Steffen Schneider, Burkert Pieske, Bernd W. Boettiger, Sebastian Ewen, Harm Wienbergen, Malte Kelm, Daniel Bock, Tobias Graf, Christoph Adler, Jochen Dutzmann, Wulf Knie, Martin Orban, Uwe Zeymer, Guido Michels, Holger Thiele
Summary: The German Cardiac Arrest Registry (G-CAR) is the first national registry in Germany to include long-term follow-up for adult out-of-hospital cardiac arrest (OHCA) patients. Its primary aim is to provide an optimized treatment perspective by systematically recording treatment course and outcomes, while evaluating various patient-reported outcomes.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Environmental Sciences
Md. Aminul Islam, Md. Arifur Rahman, Md. Jakariya, Newaz Mohammed Bahadur, Foysal Hossen, Sanjoy Kumar Mukharjee, Mohammad Salim Hossain, Atkeeya Tasneem, Md. Atiqul Haque, Francesco Sera, Iqbal Kabir Jahid, Tanvir Ahmed, Mohammad Nayeem Hasan, Md. Tahmidul Islam, Amzad Hossain, Ruhul Amin, Ananda Tiwari, Md Didar-Ul-Alam, Kuldeep Dhama, Prosun Bhattacharya, Firoz Ahmed
Summary: Wastewater based epidemiology (WBE) is an important tool in fighting COVID-19, providing cost-effective, rapid, and non-invasive insights into the health status of populations. Wastewater monitoring can reduce the burden on public health systems, aid in pandemic management, and guide informed decision-making to protect public health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Letter
Surgery
Ruhul Amin, Prosanta Pal, Kuldeep Dhama, Talha B. Emran
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Surgery
Ruhul Amin, Biplab K. Dey, Faruk Alam, Talha B. Emran
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Bart De Geest, Mudit Mishra
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Luxi Ji, Mudit Mishra, Bart De Geest
Summary: The use of SGLT2 inhibitors in HFpEF patients as a treatment method is not a significant breakthrough, as the effects are limited to hospitalization for heart failure and do not have convincing effects on metrics of heart failure-related health status. The composite endpoint used in trials, cardiovascular death and hospitalization for heart failure, is not justified as both components have distinct effects from the intervention.
Letter
Medicine, General & Internal
Ruhul Amin, Kuldeep Dhama, Talha B. B. Emran
ANNALS OF MEDICINE AND SURGERY
(2023)
Letter
Medicine, General & Internal
Ruhul Amin, Ashok K. K. Shenoy, Talha B. B. Emran
ANNALS OF MEDICINE AND SURGERY
(2023)
Letter
Medicine, General & Internal
Ilham Ben Amor, Deepak Chandran, Ruhul Amin, Talha B. Emran
ANNALS OF MEDICINE AND SURGERY
(2023)
Article
Pharmacology & Pharmacy
Ruhul Amin, Biplab Kumar Dey, Faruk Alam
Summary: The objective of this study was to develop Chronic Kidney Disease Patient Information Leaflets (CKD-PILs) and evaluate their understandability and usefulness. The CKD-PILs were prepared by referring to medical databases and assessed using readability tools. The results showed that the prepared CKD-PILs had a good design and layout, and significantly improved patients' knowledge and disease management.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2023)
Editorial Material
Biochemistry & Molecular Biology
Bart De Geest, Mudit Mishra
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fabian Freiberg, Meghna Thakkar, Wiebke Hamann, Jacobo Lopez Carballo, Rene Juettner, Felizia K. Voss, Peter M. Becher, Dirk Westermann, Carsten Tschoepe, Arnd Heuser, Oliver Rocks, Robert Fischer, Michael Gotthardt
Summary: Heart attack leads to the death of heart muscle cells, causing lesions that turn into fibrotic tissue. Inhibiting the cell contact protein CAR can limit the damage and improve survival in patients with myocardial infarction, suggesting it as a potential therapeutic target.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)