Key role of LaeA and velvet complex proteins on expression of β-lactam and PR-toxin genes in Penicillium chrysogenum: cross-talk regulation of secondary metabolite pathways

The global regulator LaeA controls production of citric acid and endoglucanases in Aspergillus carbonarius

(2016) Tore Linde et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Identification and Functional Analysis of the Mycophenolic Acid Gene Cluster of Penicillium roqueforti

(2016) Abdiel Del-Cid et al.   PLoS One

The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation

(2015) Yolanda Martínez-Burgo et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

PcFKH1, a novel regulatory factor from the forkhead family, controls the biosynthesis of penicillin in Penicillium chrysogenum

(2015) Rebeca Domínguez-Santos et al.   BIOCHIMIE

Genomic mutational analysis of the impact of the classical strain improvement program on β–lactam producing Penicillium chrysogenum

(2015) Oleksandr V. Salo et al.   BMC GENOMICS

Overexpression of the laeA gene leads to increased production of cyclopiazonic acid in Aspergillus fumisynnematus

(2015) Eun Jin Hong et al.   Fungal Biology

Regulation of secondary metabolite production in the fungal tomato pathogen Cladosporium fulvum

(2015) Scott Griffiths et al.   FUNGAL GENETICS AND BIOLOGY

The VELVET Complex in the Gray Mold Fungus Botrytis cinerea: Impact of BcLAE1 on Differentiation, Secondary Metabolism, and Virulence

(2015) Julia Schumacher et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Identification of a Classical Mutant in the Industrial Host Aspergillus niger by Systems Genetics: LaeA Is Required for Citric Acid Production and Regulates the Formation of Some Secondary Metabolites

(2015) Jing Niu et al.   G3-Genes Genomes Genetics

Direct involvement of the CreA transcription factor in penicillin biosynthesis and expression of the pcbAB gene in Penicillium chrysogenum

(2014) Cristina Cepeda-García et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

New insights into the isopenicillin N transport in Penicillium chrysogenum

(2014) M. Fernández-Aguado et al.   METABOLIC ENGINEERING

The VELVET A Orthologue VEL1 of Trichoderma reesei Regulates Fungal Development and Is Essential for Cellulase Gene Expression

(2014) Razieh Karimi Aghcheh et al.   PLoS One

Effector MiSSP7 of the mutualistic fungus Laccaria bicolor stabilizes the Populus JAZ6 protein and represses jasmonic acid (JA) responsive genes

(2014) J. M. Plett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular characterization of the PR-toxin gene cluster in Penicillium roqueforti and Penicillium chrysogenum: Cross talk of secondary metabolite pathways

(2013) Pedro I. Hidalgo et al.   FUNGAL GENETICS AND BIOLOGY

VeA and LaeA transcriptional factors regulate ochratoxin A biosynthesis in Aspergillus carbonarius

(2013) A. Crespo-Sempere et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Importance of microbial natural products and the need to revitalize their discovery

(2013) Arnold L. Demain   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Strain Improvement by Overexpression of the laeA Gene in Monascus pilosus for the Production of Monascus-Fermented Rice

(2013) Sang Sub Lee   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Molecular Regulation of Antibiotic Biosynthesis in Streptomyces

(2013) G. Liu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

VeA and MvlA repression of the cryptic orsellinic acid gene cluster inAspergillus nidulansinvolves histone 3 acetylation

(2013) Jin Woo Bok et al.   MOLECULAR MICROBIOLOGY

Functional Roles of FgLaeA in Controlling Secondary Metabolism, Sexual Development, and Virulence in Fusarium graminearum

(2013) Hee-Kyoung Kim et al.   PLoS One

The Fumagillin Gene Cluster, an Example of Hundreds of Genes under veA Control in Aspergillus fumigatus

(2013) Sourabh Dhingra et al.   PLoS One

Members of the Penicillium chrysogenum Velvet Complex Play Functionally Opposing Roles in the Regulation of Penicillin Biosynthesis and Conidiation

(2012) Katarina Kopke et al.   EUKARYOTIC CELL

Lae1 regulates expression of multiple secondary metabolite gene clusters in Fusarium verticillioides

(2012) Robert A.E. Butchko et al.   FUNGAL GENETICS AND BIOLOGY

FgVELB is associated with vegetative differentiation, secondary metabolism and virulence in Fusarium graminearum

(2012) Jinhua Jiang et al.   FUNGAL GENETICS AND BIOLOGY

The regulatory factor PcRFX1 controls the expression of the three genes of β-lactam biosynthesis in Penicillium chrysogenum

(2012) Rebeca Domínguez-Santos et al.   FUNGAL GENETICS AND BIOLOGY

Involvement of BcVeA and BcVelB in regulating conidiation, pigmentation and virulence in Botrytis cinerea

(2012) Qianqian Yang et al.   FUNGAL GENETICS AND BIOLOGY

The velvet complex governs mycotoxin production and virulence ofFusarium oxysporumon plant and mammalian hosts

(2012) Manuel S. López-Berges et al.   MOLECULAR MICROBIOLOGY

Impact of Velvet Complex on Transcriptome and Penicillin G Production in Glucose-Limited Chemostat Cultures of a β-Lactam High-Producing Penicillium chrysogenum Strain

(2012) Tânia Veiga et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

ChLae1 and ChVel1 Regulate T-toxin Production, Virulence, Oxidative Stress Response, and Development of the Maize Pathogen Cochliobolus heterostrophus

(2012) Dongliang Wu et al.   PLoS Pathogens

Characterization of an Autoinducer of Penicillin Biosynthesis in Penicillium chrysogenum

(2011) Jorge Martín et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Aspergillus oryzae laeARegulates Kojic Acid Synthesis Genes

(2011) Ken ODA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

A Single Cluster of Coregulated Genes Encodes the Biosynthesis of the Mycotoxins Roquefortine C and Meleagrin in Penicillium chrysogenum

(2011) Carlos García-Estrada et al.   CHEMISTRY & BIOLOGY

Effects of laeA deletion on Aspergillus flavus conidial development and hydrophobicity may contribute to loss of aflatoxin production

(2011) Perng-Kuang Chang et al.   Fungal Biology

Activation of a Silent Fungal Polyketide Biosynthesis Pathway through Regulatory Cross Talk with a Cryptic Nonribosomal Peptide Synthetase Gene Cluster

(2010) S. Bergmann et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Secondary metabolism in fungi: does chromosomal location matter?

(2010) Jonathan M Palmer et al.   CURRENT OPINION IN MICROBIOLOGY

Two Components of avelvet-Like Complex Control Hyphal Morphogenesis, Conidiophore Development, and Penicillin Biosynthesis in Penicillium chrysogenum

(2010) Birgit Hoff et al.   EUKARYOTIC CELL

Proteome Analysis of the Penicillin ProducerPenicillium chrysogenum

(2010) Mohammad-Saeid Jami et al.   MOLECULAR & CELLULAR PROTEOMICS

The Penicillium Chrysogenum Extracellular Proteome. Conversion from a Food-rotting Strain to a Versatile Cell Factory for White Biotechnology

(2010) Mohammad-Saeid Jami et al.   MOLECULAR & CELLULAR PROTEOMICS

LaeA Control of Velvet Family Regulatory Proteins for Light-Dependent Development and Fungal Cell-Type Specificity

(2010) Özlem Sarikaya Bayram et al.   PLoS Genetics

Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production

(2009) Diana M Harris et al.   BMC GENOMICS

Distinct Roles for VeA and LaeA in Development and Pathogenesis ofAspergillus flavus

(2009) Saori Amaike et al.   EUKARYOTIC CELL

Chromatin-level regulation of biosynthetic gene clusters

(2009) Jin Woo Bok et al.   Nature Chemical Biology

Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator

(2009) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a phenylacetate–CoA ligase fromPenicillium chrysogenum

(2008) Martijn J. Koetsier et al.   BIOCHEMICAL JOURNAL

The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum

(2008) Katarina Kosalková et al.   BIOCHIMIE

The unprocessed preprotein form IATC103S of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing

(2008) Carlos García-Estrada et al.   FUNGAL GENETICS AND BIOLOGY

The VeA regulatory system and its role in morphological and chemical development in fungi

(2008) Ana M. Calvo   FUNGAL GENETICS AND BIOLOGY

Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus

(2008) Shubha P. Kale et al.   FUNGAL GENETICS AND BIOLOGY

RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: Validation studies using β-lactam genes expression

(2008) Ricardo V. Ullán et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Mapping the interaction sites of Aspergillus nidulans phytochrome FphA with the global regulator VeA and the White Collar protein LreB

(2008) Janina Purschwitz et al.   MOLECULAR GENETICS AND GENOMICS

Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum

(2008) Marco A van den Berg et al.   NATURE BIOTECHNOLOGY

VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism

(2008) O. Bayram et al.   SCIENCE