☆ 4.7 Article

Peroxisome Proliferator-Activated Receptor-α (PPARα) Expression in a Clinical Population of Pakistani Patients with Type 2 Diabetes and Dyslipidemia

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Journal

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Volume 23, Issue 18, Pages -

Publisher

MDPI

DOI: 10.3390/ijms231810847

Keywords

type 2 diabetes; diabetic dyslipidemia; serum lipid profile; PPAR alpha gene

Funding

National University of Medical Sciences, Islamabad
Higher Education Commission (HEC), Islamabad [9141]
NIMHD (NIH) [U54 MD007597-31-5959]

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Abstract

This study describes the association between PPAR alpha expression and fasting blood glucose, HbA1c levels, and lipid levels in patients with type 2 diabetes mellitus. The results show that PPAR alpha expression is not associated with physical and biochemical parameters measured in this study and is independent of blood lipids and glycemic control. Further research is necessary to better understand the biological parameters of PPAR alpha expression.

Poor glycemic control and dyslipidemia are hallmarks of type 2 diabetes mellitus (T2DM), which predispose to cardiovascular diseases. Peroxisome proliferator-activated receptor-alpha (PPAR alpha) has been associated with atherosclerosis, but its role in T2DM is less clear. Previously, we studied PPAR alpha expression levels in diabetics with and without dyslipidemia (DD). In this study we described the association with fasting blood glucose, HbA1c levels and lipid levels of the study population. Patient demography and biochemical data were collected from hospitals in Islamabad, Pakistan, and RT-PCR data of PPAR alpha expression were retrieved from our previous study from the same cohort. We performed t-tests and regression analysis to evaluate the relationships between PPAR alpha expression and demographic and clinical variables. As expected, body mass index and HbA1c were elevated in T2DM and DD patients compared to controls. Blood lipids (total cholesterol, triglycerides, LDL and HDL) were significantly higher in the DD group compared to the other two groups. In the T2DM and DD groups, the PPAR alpha expression was not associated with any of the physical and biochemical parameters measured in this study. Expression of the PPAR alpha gene was independent of blood lipids and glycemic control in this study. Further research is necessary to better understand the biological parameters of PPAR alpha expression.

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Does vitamin C supplementation exert profitable effects on serum lipid profile in patients with type 2 diabetes? A systematic review and dose-response meta-analysis

Zahra Namkhah, Damoon Ashtary-Larky, Fatemeh Naeini, Cain C. T. Clark, Omid Asbaghi

Summary: The meta-analysis found that vitamin C supplementation significantly decreased TG and TC levels in T2DM patients, but did not affect LDL and HDL. Duration of treatment and dose of vitamin C were found to influence the improvement of lipid profile in T2DM patients. Results suggest that long-term vitamin C supplementation may be more beneficial for improving lipid profile in diabetic populations.

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