Astroglial Connexins Inactivation Increases Relapse of Depressive-like Phenotype after Antidepressant Withdrawal

Brain–heart communication in health and diseases

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Downregulation of connexin 43 potentiates amitriptyline-induced brain-derived neurotrophic factor expression in primary astrocytes through lysophosphatidic acid receptor1/3, Src, and extracellular signal-regulated kinase

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Inhibition of astrocyte hemichannel improves recovery from spinal cord injury

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Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs

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The gap junction inhibitor INI-0602 attenuates mechanical allodynia and depression-like behaviors induced by spared nerve injury in rats

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Dysfunction of astrocytic connexins 30 and 43 in the medial prefrontal cortex and hippocampus mediates depressive-like behaviours

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Venlafaxine Improves the Cognitive Impairment and Depression-Like Behaviors in a Cuprizone Mouse Model by Alleviating Demyelination and Neuroinflammation in the Brain

(2019) Yanbo Zhang et al.   Frontiers in Pharmacology

Differential Peripheral Proteomic Biosignature of Fluoxetine Response in a Mouse Model of Anxiety/Depression

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Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder

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Antidepressants Impact Connexin 43 Channel Functions in Astrocytes

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Venlafaxine reverses decreased proliferation in the subventricular zone in a rat model of early life stress

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Attenuated Levels of Hippocampal Connexin 43 and its Phosphorylation Correlate with Antidepressant- and Anxiolytic-Like Activities in Mice

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Restraint stress increases hemichannel activity in hippocampal glial cells and neurons

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Amitriptyline up-regulates connexin43-gap junction in rat cultured cortical astrocytes via activation of the p38 and c-Fos/AP-1 signalling pathway

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Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression

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Astrocytic abnormalities and global DNA methylation patterns in depression and suicide

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Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

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Pannexins form gap junctions with electrophysiological and pharmacological properties distinct from connexins

(2014) Giriraj Sahu et al.   Scientific Reports

Hemichannels: new roles in astroglial function

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The Monoaminergic Tripartite Synapse: A Putative Target for Currently Available Antidepressant Drugs

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Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue

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The vascular depression hypothesis: mechanisms linking vascular disease with depression

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Astrocyte-derived ATP modulates depressive-like behaviors

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Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

(2012) Jimmy Stehberg et al.   FASEB JOURNAL

Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels

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Functional consequences of abnormal Cx43 expression in the heart

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Inhibition of 11β-hydroxysteroid dehydrogenase 1 by carbenoxolone affects glucose homeostasis and obesity in db/db mice

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Acute d-serine treatment produces antidepressant-like effects in rodents

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Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: Relevance to emotionality and sex

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Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response

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Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats

(2011) Jian-Dong Sun et al.   NEUROPSYCHOPHARMACOLOGY

Astroglial networks: a step further in neuroglial and gliovascular interactions

(2010) Christian Giaume et al.   NATURE REVIEWS NEUROSCIENCE

Deletion of Astrocyte Connexins 43 and 30 Leads to a Dysmyelinating Phenotype and Hippocampal CA1 Vacuolation

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Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

(2009) Denis J. David et al.   NEURON

Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrus

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Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity

(2008) Ashley Taylor et al.   BIOLOGICAL CHEMISTRY

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

(2008) Mounira Banasr et al.   BIOLOGICAL PSYCHIATRY