Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 36, Issue -, Pages 326-333Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2016.02.023
Keywords
Layer-by-layer assembly; Collagen hydrogel; Multifunctional film; Controlled drug release
Funding
- Bio & Medical Technology Development Program of the National Research Foundation of Korea (NRF) - Korean Government [2012M3A9C6050104]
- National Research Foundation of Korea (NRF) - Korean Government Ministry of Science, ICT & Future Planning [2013R1A1A1076126]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI14C-3266, HI15C-1653]
- Cooperative Research Program for Agriculture Science & Technology Development Rural Development Administration, Republic of Korea [PJ00998601]
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Hydrogels have been mainly used for biomedical applications owing to their biocompatibility and high water content. However, they have serious limitations such as poor mechanical stability and fast release of the incorporated drug. To overcome these problems, we prepared collagen hydrogel (Col-H) with layer-by-layer (LbL) self-assembled films (Col-H) to develop multifunctional hydrogel. We prepared LbL films using tannic acid and lignin for multi-functional properties. In addition, we incorporated doxorubicin as a model drug, which is widely used for cancer therapy. Furthermore, the prepared films exhibit antibacterial effect against gram-positive and negative bacteria and endure higher compression stress than bare Col-H. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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