Review
Biochemistry & Molecular Biology
Changwon Yang, Whasun Lim, Gwonhwa Song
Summary: Biologically active compounds used in agriculture can easily spill into aquatic environments, leading to the accumulation of insecticides and other chemicals in aquatic organisms. These insecticides may induce immunotoxic responses, altering the immune system of fish and even causing death in severe cases.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Environmental Sciences
Fabian Essfeld, Hannes Reinwald, Gabriela Salinas, Christoph Schaefers, Elke Eilebrecht, Sebastian Eilebrecht
Summary: The detection of immunotoxicity is currently neglected in ecotoxicological hazard assessment of chemicals. Transcriptome profiling in zebrafish embryos can help identify gene biomarkers and comprehensively characterize immunosuppression, contributing to the development of molecular biomarker-based environmental hazard assessment of chemicals in the future.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Julin Yuan, Yao Zheng, Zhimin Gu
Summary: The study compared the effects of cypermethrin on the hepatic expression profiles in red claw crayfish using transcriptomic and proteomic approaches, revealing that cypermethrin can induce antioxidant and biotransformation modulation variations to resist immunotoxicity and oxidative damages.
Article
Marine & Freshwater Biology
Florencia Arrighetti, Sonia M. Landro, Sabrina M. L. Lavarias
Summary: The aim of this study was to evaluate the toxic effects of the pesticide cypermethrin on the digestive gland of the apple snail. The study found that cypermethrin exposure caused tissue damage in the digestive gland, including disorganisation of the connective tissue and various pathological conditions. Some histological and histochemical parameters were found to be sensitive indicators of cypermethrin exposure in the snail species.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Camila F. Rutkoski, Natani Macagnan, Alexandre Folador, Vrandrieli J. Skovronski, Aline M. B. do Amaral, Jossiele Wesz Leitemperger, Maiara Dorneles Costa, Paulo A. Hartmann, Caroline Muller, Vania L. Loro, Marilia T. Hartmann
Summary: This study revealed that cypermethrin and fipronil had neurotoxic and oxidative stress effects on Physalaemus gracilis, including reduced enzyme activity and increased antioxidant enzyme activity. Biochemical biomarkers can be utilized for monitoring the toxicity of insecticides on P. gracilis for preservation purposes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cell Biology
Dongmei Yan, Jialin Xu, Yongjun Chen, Qingchun Huang
Summary: This study used an insect hemocyte system to evaluate the impact of pesticides with different modes of action on hemocytes. The results showed that piericidin A was the most cytotoxic to hemocytes, while imidacloprid was the least toxic. The alterations in hemocyte functions compromised immunity.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2022)
Article
Biochemistry & Molecular Biology
Ritu Sharma, Rajinder Jindal, Caterina Faggio
Summary: The study evaluated the protective effects of Cassia fistula in Catla catla exposed to the synthetic pyrethroid cypermethrin. Fish exposed to a sub-lethal concentration of the pesticide showed decreased antioxidant activity, increased lipid peroxidation, and histopathological alterations. Dietary supplementation of Cassia fistula bark extract improved antioxidant activity, reduced lipid peroxidation, and prevented histopathological alterations, suggesting its potential in mitigating pesticide-induced toxic effects.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Environmental Sciences
Gabriele Lori, Roberta Tassinari, Laura Narciso, Ion Udroiu, Antonella Sgura, Francesca Maranghi, Sabrina Tait
Summary: Mancozeb and zoxamide showed cytotoxicity in HepG2 and A549 cells at high concentrations, with slightly different mechanisms of action but no increase in intracellular reactive oxygen species. While Mancozeb exhibited genotoxicity, Zoxamide did not induce DNA damage, yet both had aneugenic potential.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biotechnology & Applied Microbiology
Mengmei Zhang, Yuan Chen, Jinghui Lai, Xingjie Wang, Kaidi Hu, Jianlong Li, Qin Li, Li He, Shujuan Chen, Aiping Liu, Xiaolin Ao, Yong Yang, Shuliang Liu
Summary: Lactiplantibacillus plantarum RS60 demonstrates effective biosorption of cypermethrin, with its cellular components and functional groups playing crucial roles in the removal process. This study provides valuable insights into the mechanisms underlying cypermethrin biosorption by lactic acid bacteria.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Benedikt Luckner, Fabian Essfeld, Steve U. Ayobahan, Elke Richling, Elke Eilebrecht, Sebastian Eilebrecht
Summary: This study analyzed the transcriptomic profiles of zebrafish embryos in response to immunosuppressive and immunostimulatory compounds, aiming to explore the immunotoxic modes of action. The research validated some genes as potential biomarkers for immunotoxicity and identified new biomarkers with differentiating power.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Pimchanok Nuchniyom, Ketsarin Intui, Jiraporn Laoung-on, Churdsak Jaikang, Ranida Quiggins, Kornravee Photichai, Paiwan Sudwan
Summary: This study aimed to determine the effects of Nelumbo nucifera extract on hepatotoxicity and oxidative stress induced by mancozeb. The results showed that the extract could suppress the toxicity of mancozeb, reduce liver injury, and regulate oxidative stress, making it a safe and effective natural antioxidant supplement.
Article
Environmental Sciences
Yijing Han, Qianqian Zhang, Lizhu Chen, Jianmin Zhao, Dinglong Yang
Summary: This study discovered the effect of deltamethrin (DLM) on the formation of extracellular traps (ETosis) in Manila clam hemocytes. It was found that the release of ETs induced by high concentration of DLM was mainly achieved through the induction of reactive oxygen species (ROS) burst and myeloperoxidase (MPO) production. In addition, DLM also led to mitochondrial dysfunction. These findings provide new insights into the immunotoxicity of DLM in clams and lay the foundation for health assessment in bivalves.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Immunology
Danielle F. Mello, Christina M. Bergemann, Kinsey Fisher, Rojin Chitrakar, Shefali R. Bijwadia, Yang Wang, Alexis Caldwell, Larry Ryan Baugh, Joel N. Meyer
Summary: Mitochondria play a vital role in host immunometabolism and their exposure to toxicants can disrupt immunometabolic pathways. This study investigates the effect of rotenone, a mitochondrial toxicant, on C. elegans immunometabolism and disease susceptibility. The results show that rotenone alters immunometabolic pathways and increases susceptibility to Pseudomonas aeruginosa while increasing resistance to Salmonella enterica. The activation of the mitochondrial unfolded protein response is implicated in this divergent effect.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Karime Guadalupe Bernal-Gonzalez, Carlos Eduardo Covantes-Rosales, Milton Rafael Camacho-Perez, Ulises Mercado-Salgado, Victor Wagner Barajas-Carrillo, Daniel Alberto Giron-Perez, Ashley Carolina Montoya-Hidalgo, Karina Janice Guadalupe Diaz-Resendiz, Rocio Guadalupe Barcelos-Garcia, Gladys Alejandra Toledo-Ibarra, Manuel Ivan Giron-Perez
Summary: Organophosphate pesticides (OPs) have widespread use and can impact the immune response and defense mechanisms of non-target organisms. This review explores the toxic effects of OPs on the immune system of invertebrates and vertebrates, highlighting the need for more research on non-target species and understanding their susceptibility to infectious diseases. The study underscores the importance of assessing the individual and ecological impact of OPs in order to protect populations and ecosystems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Marine & Freshwater Biology
Hongjing Zhao, Yue Zhang, Lulu Hou, Hongmin Lu, Yingxue Zhang, Mingwei Xing
Summary: This study highlights the potential ecological risks posed by antibiotics and pesticides to aquatic environments and products. It emphasizes the importance of the gut-liver axis as a comprehensive pathway for assessing the toxicity in fish exposed to environmental contaminants.
AQUATIC TOXICOLOGY
(2023)