Upregulation of IFN-Inducible and Damage-Response Pathways in Chronic Graft-versus-Host Disease

Antibodies from donor B cells perpetuate cutaneous chronic graft-versus-host disease in mice

(2016) H. Jin et al.   BLOOD

CXCL10: most consistent cGVHD biomarker?

(2016) S. Paczesny et al.   BLOOD

Heterogeneity of chronic graft-versus-host disease biomarkers: association with CXCL10 and CXCR3+ NK cells

(2016) A. Kariminia et al.   BLOOD

Biomarker Panel for Chronic Graft-Versus-Host Disease

(2016) Jeffrey Yu et al.   JOURNAL OF CLINICAL ONCOLOGY

Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease

(2016) Tracy A. Delaney et al.   JOURNAL OF IMMUNOLOGY

Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation: A Report from the Center for International Blood and Marrow Transplant Research

(2015) Sally Arai et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease

(2015) R. Flynn et al.   BLOOD

Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis

(2015) Xiang Guo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Clinical significance of autoantibodies in a large cohort of patients with chronic graft-versus-host disease defined by NIH criteria

(2014) Zoya Kuzmina et al.   AMERICAN JOURNAL OF HEMATOLOGY

Post-Transplantation B Cell Activating Factor and B Cell Recovery before Onset of Chronic Graft-versus-Host Disease

(2014) Caron A. Jacobson et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease

(2014) S. Spoerl et al.   BLOOD

Increased Th17/Treg ratio in chronic liver GVHD

(2014) F Malard et al.   BONE MARROW TRANSPLANTATION

Excessive Production of IFN-  in Patients with Systemic Lupus Erythematosus and Its Contribution to Induction of B Lymphocyte Stimulator/B Cell-Activating Factor/TNF Ligand Superfamily-13B

(2014) M. Harigai et al.   JOURNAL OF IMMUNOLOGY

Chronic Exposure to Glucocorticoids Shapes Gene Expression and Modulates Innate and Adaptive Activation Pathways in Macrophages with Distinct Changes in Leukocyte Attraction

(2014) M. D. B. van de Garde et al.   JOURNAL OF IMMUNOLOGY

Anti–IL-12/23 p40 Antibody Attenuates Experimental Chronic Graft-versus-Host Disease via Suppression of IFN-γ/IL-17–Producing Cells

(2014) Sachiyo Okamoto et al.   JOURNAL OF IMMUNOLOGY

Comparative analysis of FoxP3+ regulatory T cells in the target tissues and blood in chronic graft versus host disease

(2014) M M Imanguli et al.   LEUKEMIA

Sifalimumab, a Human Anti-Interferon-α Monoclonal Antibody, in Systemic Lupus Erythematosus: A Phase I Randomized, Controlled, Dose-Escalation Study

(2013) Michelle Petri et al.   ARTHRITIS AND RHEUMATISM

Plasma CXCL9 elevations correlate with chronic GVHD diagnosis

(2013) C. L. Kitko et al.   BLOOD

Diverse T-cell responses characterize the different manifestations of cutaneous graft-versus-host disease

(2013) M.-C. Bruggen et al.   BLOOD

The Nlrp3 inflammasome regulates acute graft-versus-host disease

(2013) Dragana Jankovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN R signaling mediates alloreactive T-cell trafficking and GVHD

(2012) J. Choi et al.   BLOOD

Chemokine-mediated tissue recruitment of CXCR3+ CD4+ T cells plays a major role in the pathogenesis of chronic GVHD

(2012) J. E. Croudace et al.   BLOOD

Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease

(2012) Apostolos Kontzias et al.   CURRENT OPINION IN PHARMACOLOGY

Safety profile and clinical activity of sifalimumab, a fully human anti-interferon   monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study

(2011) J. T. Merrill et al.   ANNALS OF THE RHEUMATIC DISEASES

Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway

(2011) B. W. Higgs et al.   ANNALS OF THE RHEUMATIC DISEASES

Localization of Sclerotic-type Chronic Graft-vs-Host Disease to Sites of Skin Injury

(2011) Kathryn J. Martires   ARCHIVES OF DERMATOLOGY

Sclerotic-type chronic GVHD of the skin: clinical risk factors, laboratory markers, and burden of disease

(2011) K. J. Martires et al.   BLOOD

Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17

(2011) H. Nishimori et al.   BLOOD

B Cell and BAFF Dependence of IFN- -Exaggerated Disease in Systemic Lupus Erythematosus-Prone NZM 2328 Mice

(2011) N. Jacob et al.   JOURNAL OF IMMUNOLOGY

Soluble BAFF Levels Inversely Correlate with Peripheral B Cell Numbers and the Expression of BAFF Receptors

(2011) M. Kreuzaler et al.   JOURNAL OF IMMUNOLOGY

Danger signals activating innate immunity in graft-versus-host disease

(2011) Robert Zeiser et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Systemic sclerosis and lupus: Points in an interferon-mediated continuum

(2010) Shervin Assassi et al.   ARTHRITIS AND RHEUMATISM

Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD

(2010) Shoba Amarnath et al.   Autophagy

FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis

(2010) Paola Maderna et al.   FASEB JOURNAL

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

Dissecting Interferon-Induced Transcriptional Programs in Human Peripheral Blood Cells

(2010) Simon J. Waddell et al.   PLoS One

Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa

(2009) M. M. Imanguli et al.   BLOOD

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

(2009) T. Yi et al.   BLOOD

Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease

(2009) S. Sarantopoulos et al.   BLOOD

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Severe Systemic Lupus Erythematosus Induced by Antiviral Treatment for Hepatitis C

(2008) Vincent Ho et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR3 ligand–mediated skin inflammation in cutaneous lichenoid graft-versus-host disease

(2008) Joerg Wenzel et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Direct multiplexed measurement of gene expression with color-coded probe pairs

(2008) Gary K Geiss et al.   NATURE BIOTECHNOLOGY

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY

Biomarkers in newly diagnosed pediatric-extensive chronic graft-versus-host disease: a report from the Children's Oncology Group

(2007) H. Fujii et al.   BLOOD