Article
Polymer Science
Isabela Monteiro Cesar Oyama, Erick Gabriel Ribeiro dos Anjos, Guilherme Ferreira de Melo Morgado, Eduardo Ferreira Martins, Fabio Roberto Passador
Summary: Graphene nanoplatelets (GNP) were added to biodegradable blends of poly(acid lactic)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PLA/PHBV) to prepare antistatic and antimicrobial packaging materials for the electronic components industry. The addition of GNP improved the mechanical strength, electrical conductivity, and antimicrobial activity of the packaging materials. The best balance of mechanical properties, electrical resistivity, and antimicrobial activity was achieved with PLA/PHBV blend-based GNP nanocomposite containing 5 wt% of GNP.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Polymer Science
Isabela Monteiro Cesar Oyama, Erick Gabriel Ribeiro dos Anjos, Guilherme Ferreira de Melo Morgado, Tayra Rodrigues Brazil, Maria Cristina Kantun-Uicab, Fabio Roberto Passador
Summary: Glassy carbon and graphene nanoplatelets were used as fillers in the preparation of antistatic and biodegradable composites. The addition of glassy carbon and graphene nanoplatelets increases the elastic modulus and decreases the electrical resistivity, making them suitable for electrostatic discharge protection packaging. However, high crystallinity hinders the biodegradation process.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Environmental Sciences
Sung-Hyun Kim, So-Hye Hong, Jin Hee Lee, Dong Han Lee, Kikyung Jung, Jun-Young Yang, Hyo-Sook Shin, JeongPyo Lee, Jayoung Jeong, Jae-Ho Oh
Summary: The study found that graphene nanoplatelets do not induce skin sensitization and do not cause cytotoxicity or skin toxicity in experiments using alternative test methods.
Article
Materials Science, Multidisciplinary
Jiabin Hou, Wencong Zhang, Guorong Cui, Wenzhen Chen, Qiang Ma, Shuo Wu
Summary: The graphene nanoplates (GNPs)/TA15 composites were fabricated by pre-sintering and hot extrusion. During pre-sintering, a chemical reaction occurred between GNPs and the Ti matrix, forming TiC particles at the interface. This resulted in a new interface with TiC plates distributed among large TiC particles. This work provides new insight into the evolution and interface reaction process of GNPs/Ti composites during extrusion.
Article
Chemistry, Multidisciplinary
Andrew D. Pendergast, Zejun Deng, Fouad Maroun, Christophe Renault, Jeffrey E. Dick
Summary: Nanoparticles interact with various interfaces, and quantifying their dynamic changes near interfaces is challenging. This study combined optical microscopy, single-entity electrochemistry, and numerical simulations to elucidate the dynamic motion of graphene nanoplatelets at a gold ultramicroelectrode. The results revealed single nanoplatelet angular velocities on the order of 0.5-2 degrees/ms, providing valuable insights into nanoparticle dynamics at the nanoscale.
Article
Materials Science, Composites
Kent Mardlin, Osayuki Osazuwa, Marianna Kontopoulou, Weawkamol Leelapornpisit
Summary: By incorporating graphite and graphene nanoplatelets, the thermal conductivity and mechanical properties of the composites can be enhanced, with a significant increase in toughness up to 650% when adding 30% GNPs.
COMPOSITES SCIENCE AND TECHNOLOGY
(2022)
Article
Energy & Fuels
Marwa Zeitoun, Marwa Adel, Fuad Abulfotouh, Shaker Ebrahim
Summary: This study investigated the impact of various graphite derivatives on the thermophysical properties of octadecane as a base material for Composite Phase Change Material (CPCM). The results showed that RGO was the best additive, significantly increasing the specific heat capacity of OD, while EG reduced it.
JOURNAL OF ENERGY STORAGE
(2021)
Article
Materials Science, Ceramics
Aiyang Wang, Lanxin Hu, Qianglong He, Chun Liu, Tian Tian, Zhixiao Zhang, Chenhong Yi, Fan Zhang, Weimin Wang, Hao Wang, Zhengyi Fu
Summary: The study found that adding 10% graphene nanoplatelets to B4C composites resulted in the highest electrical conductivity and lowest surface roughness, significantly improving the material removal rate. The material removal mechanisms were analyzed for different GNP contents, showing that increasing GNP content led to different removal methods.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
He Ren, Eunice Cunha, Zheling Li, Lei Wang, Ian A. Kinloch, Dian Yi, Andrew Kretinin, Quanji Sun, Zhaodong Fan, Robert J. Young
Summary: The effect of silane-functionalized graphene nanoplatelets on the mechanical properties and thermal conductivity of reinforced silicone rubber was studied, with experimental results matching theoretical predictions.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Panagiotis Gavallas, Dimitrios Savvas, George Stefanou
Summary: In this work, the mechanical behavior of graphene nanoplatelets (GNPs) with different planar defects is investigated. The stiffness of GNPs is severely reduced by vacancy defects, leading to significant variability. Inplane behavior is more susceptible to the effect of defects compared to out of plane behavior.
MECHANICS OF MATERIALS
(2023)
Article
Environmental Sciences
Zhuang Wang, Fan Zhang, Martina G. Vijver, Willie J. G. M. Peijnenburg
Summary: The study revealed enhanced cytotoxicity of a mixture of graphene-based carbon nanomaterials and nano-zirconium oxide to freshwater algae, attributed to intracellular oxidative stress and cellular membrane changes. Mitochondria-generated ROS played a significant role in the cellular response, indicating oxidative damage to algal cells. Additionally, reduced graphene oxide showed higher cytotoxicity and oxidative stress compared to graphene nanoplatelets.
Article
Materials Science, Composites
Santhanakrishnan Mamallan, Venkateshwaran Narayanan
Summary: This study discusses the effect of sonication time on the mechanical properties of graphene nanoplatelets (GnPs) glass fiber composites. It is found that the appropriate sonication time can enhance the tensile strength and modulus performance, as well as the flexural strength and modulus performance of the nano-composites.
POLYMER COMPOSITES
(2022)
Article
Physics, Applied
Rajkumar Jaiswar, Francisco Mederos-Henry, Sophie Hermans, Jean-Pierre Raskin, Isabelle Huynen
Summary: This paper investigates the nonlinear properties of graphene nanoplatelets decorated with Fe3O4 magnetic nanoparticles, proposing three different models to explain electronic transport in the nanocomposites. The study shows that as the loading of magnetic nanoparticles decreases, the barrier height also decreases, indicating an increase in impedance of the IDE. Additionally, impedance spectroscopy with different DC biases reveals the necessity of a constant phase element in the equivalent circuit to fit the AC response of the IDE, confirming the presence of random phenomena in transport according to the DRRN model.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Engineering, Multidisciplinary
Aldobenedetto Zotti, Simona Zuppolini, Anna Borriello, Mauro Zarrelli
Summary: This review article provides an overview of the development of GNP/polymer nanocomposites in recent years. The article discusses the preparation techniques for GNPs and the synthetic routes for AGNPs, as well as the mixing techniques and resulting microstructure of GNPs/polymer nanocomposites. Furthermore, the article presents and discusses the electrical, thermal and mechanical properties of the hybrid systems, correlating the characteristics of GNPs to the properties of the nanocomposites.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Chemistry, Physical
Huidong Li, Yelin Xia, Min Xie, Chuan Shi, Jianbo Lei
Summary: Graphene nanoplatelets (GNPs) were added to NiCu alloy using mechanical alloying (MA) and laser melting deposition (LMD) methods to form a reinforced composite coating. The dispersed in-situ graphite/Ni-Cu (G/Ni-Cu) particles in the composite coating resulted in increased microhardness and significantly reduced wear mass loss compared to the NiCu coating.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Review
Neurosciences
Seyed H. Shahcheraghi, Jamshid Ayatollahi, Marzieh Lotfi, Alaa A. A. Aljabali, Mazhar S. Al-Zoubi, Pritam K. Panda, Vijay Mishra, Saurabh Satija, Nitin B. Charbe, Angel Serrano-Aroca, Bojlul Bahar, Kazuo Takayama, Rohit Goyal, Amit Bhatia, Abdulmajeed G. Almutary, Abdullah M. Alnuqaydan, Yachana Mishra, Poonam Negi, Aaron Courtney, Paul A. McCarron, Hamid A. Bakshi, Murtaza M. Tambuwala
Summary: Neuropsychiatric disorders have a significant impact on healthcare systems and economies. Current drug-based treatments for these disorders are often ineffective and costly. Gene therapy, an experimental concept, shows promise in alleviating symptoms, slowing disease progression, and repairing defective genes. While it requires the integration of various scientific disciplines, gene therapy has the potential to be a novel approach for treating neuropsychiatric disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Biotechnology & Applied Microbiology
Nitin Bharat Charbe, Murtaza Tambuwala, Sushesh Srivatsa Palakurthi, Amol Warokar, Altijana HronniC-JahjefendiC, Hamid Bakshi, Flavia Zacconi, Vijay Mishra, Saurabh Khadse, Alaa A. Aljabali, Mohamed El-Tanani, Angel Serrano-Aroca, Srinath Palakurthi
Summary: This article provides an overview of the latest development and application of 3D bioprinting in regenerating skeletal muscle tissues and restoring the functional abilities of damaged craniofacial tissue. It discusses the limitations of traditional surgical repair and highlights the potential of 3D bioprinting in producing patient-specific functional implants.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Mohamed El-Tanani, Arwa Omar Al Khatib, Belal O. Al-Najjar, Ashok K. Shakya, Yahia El-Tanani, Yin-Fai Lee, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Alaa A. Aljabali, Rohit Goyal, Poonam Negi, Marzieh Ramezani Farani, Maryam Moradi Binabaj, Amir Gholami, Maryam Moradi Binabaj, Nitin B. Charbe, Murtaza M. Tambuwala
Summary: There has been extensive research on breast cancer in recent decades, resulting in important breakthroughs in the treatment of both primary and metastatic breast cancers. Despite the availability of advanced treatment options, treating breast cancer remains a challenge, requiring a combination of traditional chemotherapeutic drugs and surgical options. Recent developments have led to a wide range of treatment options including chemotherapeutic drugs, endocrine system-based treatments, biological therapies, gene therapy, and innovative techniques.
CELLULAR SIGNALLING
(2023)
Review
Pharmacology & Pharmacy
Alaa A. A. Aljabali, Rasha M. Bashatwah, Mohammad A. Obeid, Vijay Mishra, Yachana Mishra, Angel Serrano-Aroca, Kenneth Lundstrom, Murtaza M. Tambuwala
Summary: mRNA vaccines are an attractive alternative to conventional vaccination technologies due to their superior efficacy, rapid engineering, low-cost manufacturing, and safe delivery prospects. They have shown promising results in targeting infectious diseases and various types of cancer in both in vivo and in vitro studies. Issues related to mRNA stability and immunogenicity have been addressed, and current mRNA vaccines can generate robust immune responses without being constrained by the recipient's major histocompatibility complex haplotype.
DRUG DISCOVERY TODAY
(2023)
Review
Biochemistry & Molecular Biology
Alaa A. Aljabali, Mohammad A. Obeid, Rasha M. Bashatwah, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Mohamed El-Tanani, Altijana Hromic-Jahjefendic, Deepak N. Kapoor, Rohit Goyal, Gowhar A. Naikoo, Murtaza M. Tambuwala
Summary: Nanomaterials have been extensively studied in the medical and industrial sectors, but their potential toxicities have raised concerns. Researchers are interested in how nanoparticles interact with the immune system and their biomolecules. This review examines literature on the immunostimulatory and immunosuppressive effects of nanomaterials and their interactions with immune cells, as well as the possibility of creating stealth nanomaterials that evade the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mohamed El-Tanani, Hamdi Nsairat, Vijay Mishra, Yachana Mishra, Alaa A. A. Aljabali, Angel Serrano-Aroca, Murtaza M. Tambuwala
Summary: Ran is a member of the Ras superfamily of proteins, regulating nucleocytoplasmic trafficking and mitosis by regulating spindle formation and nuclear envelope reassembly. Aberrant Ran expression in cancer is due to upstream dysregulation and abnormal activation of signaling pathways. Overexpression of Ran affects cell phenotype and has been found in various cancers, correlating with tumor grade and metastasis. Increased dependence on Ran for spindle formation and mitosis, as well as dysregulation of nucleocytoplasmic transport, contribute to the increased malignancy and invasiveness associated with Ran overexpression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Mohamed El-Tanani, Hamdi Nsairat, Alaa A. Aljabali, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Gowhar A. Naikoo, Walhan Alshaer, Murtaza M. Tambuwala
Summary: The mammalian target of rapamycin (mTOR), a signalling system, is necessary for various cell proliferation activities. It recognizes PI3KAKT stress signals as a serine-threonine kinase. The abnormal regulation of mTOR pathway has been proven to be crucial in cancer growth and advancement. This review primarily discusses the normal functions of mTOR as well as its abnormal roles in cancer development.
Article
Chemistry, Physical
Jose Luis Aparicio-Collado, Qiqi Zheng, Jose Molina-Mateo, Constantino Torregrosa Cabanilles, Ana Vidaurre, Angel Serrano-Aroca, Roser Sabater i Serra
Summary: Electroactive composite materials, consisting of a graphene-based hydrogel with dispersed nanosheets, show promise for musculoskeletal tissue engineering. The nanohybrid hydrogels have an interconnected porous structure and high water-absorption capacity. The addition of graphene nanosheets improves the thermal stability, mechanical properties, and electrical conductivity of the hydrogels. Furthermore, these materials are biocompatible and can induce myoblast proliferation, making them highly suitable for musculoskeletal tissue engineering.
Article
Biochemistry & Molecular Biology
Beatriz Salesa, Patricia Ferrus-Manzano, Alberto Tunon-Molina, Alba Cano-Vicent, Marcelo Assis, Juan Andres, Angel Serrano-Aroca
Summary: Gold nanoparticles (AuNPs) are promising for biomedical applications due to their excellent biosafety. However, their cytotoxicity in human HaCaT cells is time-dependent, and concentrations above 300 μg/mL show toxic activity. Low concentrations of AuNPs do not exhibit significant proliferative or antiviral activity, and gene expression is not modified after exposure to AuNPs for 24 hours. These results indicate that AuNPs are stable inactive materials suitable for biomedical and clinical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Alba Cano-Vicent, Alberto Tunon-Molina, Miguel Marti, Angel Serrano-Aroca
Summary: Chitosan films were prepared using an acetic acid-based solution and were found to be biocompatible and possess potent antiviral activity against enveloped and non-enveloped viruses. In vitro tests showed up to 99.98% and 99.92% viral inactivation against the phi 6 enveloped bacteriophage and MS2 non-enveloped bacteriophage, respectively. This suggests that the chitosan/acetic acid film has great potential for use in biomedical applications requiring biodegradable broad-spectrum antiviral materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alberto Tunon-Molina, Alba Cano-Vicent, Angel Serrano-Aroca
Summary: The global COVID-19 pandemic has highlighted the need for new antimicrobial compounds. This study investigates the antiviral properties of tiger nut milk (TNM) against enveloped and non-enveloped viruses. The results show that TNM is effective against enveloped viruses and adding sugar improves its antiviral properties against both enveloped and non-enveloped viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Chemistry, Physical
Roser Sabater Serra, Angel Serrano-Aroca
Article
Chemistry, Multidisciplinary
Alba Cano-Vicent, Alberto Tunon-Molina, Hamid Bakshi, Roser Sabater i Serra, Iman M. M. Alfagih, Murtaza M. M. Tambuwala, Angel Serrano-Aroca
Summary: This study investigated an alginate hydrogel crosslinked with calcium and varying amounts of zinc cations, and explored its properties in terms of anticancer, antiviral, antibacterial, water absorption, and compound release. The results demonstrated that the hydrogel film with the highest zinc content exhibited similar water sorption properties to calcium alginate, and released an appropriate amount of zinc to exert anticancer, antibacterial, and antiviral activities. Moreover, the film was proven to be non-toxic in vitro and in vivo, suggesting its potential for biomedical applications.
Review
Pharmacology & Pharmacy
Seyed Hossein Shahcheraghi, Seyed Hadi Shahcheraghi, Marzieh Lotfi, Malihe Lotfi, Seyed Hossein Khaleghinejad, Zara M. Tambuwala, Vijay Mishra, Yachana Mishra, Angel Serrano-Aroca, Alaa A. A Aljabali, Mohamed El-Tanani, Gowhar A. Naikoo, Sai Raghuveer Chava, Nitin B. Charbe, Shivani Bharti, Saravana Kumar Jaganathan, Rohit Goyal, Poonam Negi, Murtaza M. Tambuwala, Oladipo Folorunso
Summary: This review explores the potential of photonic nanoparticles for cancer theranostics, highlighting their unique properties and photonics capabilities. However, the size of the particles is crucial to their absorption of near-infrared light and therapeutic potential. Challenges such as toxicity, immune system clearance, and targeted delivery to the tumor are also discussed. Ongoing research suggests that photonic nanoparticles have potential for cancer theranostics, but further investigation and development are necessary for clinical use.
THERAPEUTIC DELIVERY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)