HIV-1 Latency-Reversing Agents Prostratin and Bryostatin-1 Induce Blood–Brain Barrier Disruption/Inflammation and Modulate Leukocyte Adhesion/Transmigration

Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy

(2016) Carolina Gutiérrez et al.   AIDS

Toxicity and in vitro activity of HIV-1 latency-reversing agents in primary CNS cells

(2016) Lachlan R. Gray et al.   JOURNAL OF NEUROVIROLOGY

Antiretroviral drugs do not interfere with bryostatin-mediated HIV-1 latency reversal

(2015) Marta Martínez-Bonet et al.   ANTIVIRAL RESEARCH

Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications

(2015) Suzi Hong et al.   BRAIN BEHAVIOR AND IMMUNITY

Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1

(2015) S. Bouchat et al.   EMBO Molecular Medicine

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier

(2015) Michael Abadier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Anti–IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus

(2015) Jiyong Zhang et al.   FASEB JOURNAL

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Tumour necrosis factor-α-mediated disruption of cerebrovascular endothelial barrier integrityin vitroinvolves the production of proinflammatory interleukin-6

(2015) Keith D. Rochfort et al.   JOURNAL OF NEUROCHEMISTRY

Nanoformulation of antiretroviral drugs enhances their penetration across the blood brain barrier in mice

(2015) Luisa Fiandra et al.   Nanomedicine-Nanotechnology Biology and Medicine

Synergistic Activation of Latent HIV-1 Expression by Novel Histone Deacetylase Inhibitors and Bryostatin-1

(2015) Marta Martínez-Bonet et al.   Scientific Reports

Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-ĸB-dependent mechanism

(2015) Laura Díaz et al.   Scientific Reports

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

Nanoemulsion-based intranasal drug delivery system of saquinavir mesylate for brain targeting

(2013) Hitendra S. Mahajan et al.   DRUG DELIVERY

Histone Deacetylase Inhibitors (HDACis) That Release the Positive Transcription Elongation Factor b (P-TEFb) from Its Inhibitory Complex Also Activate HIV Transcription

(2013) Koen Bartholomeeusen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier

(2013) R. Gorina et al.   JOURNAL OF IMMUNOLOGY

Cytokines in CSF correlate with HIV-associated neurocognitive disorders in the post-HAART era in China

(2013) Lin Yuan et al.   JOURNAL OF NEUROVIROLOGY

Bryostatin Improves Survival and Reduces Ischemic Brain Injury in Aged Rats After Acute Ischemic Stroke

(2013) Zhenjun Tan et al.   STROKE

Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients

(2012) Sophie Bouchat et al.   AIDS

A dynamic real-time method for monitoring epithelial barrier function in vitro

(2012) Mingjiao Sun et al.   ANALYTICAL BIOCHEMISTRY

Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells

(2012) Georgette Kanmogne et al.   International Journal of Nanomedicine

Guanine Nucleotide-Binding Protein Gαi2: A New Partner of Claudin-5 that Regulates Tight Junction Integrity in Human Brain Endothelial Cells

(2012) Anny-Claude Luissint et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Programming of neurotoxic cofactor CXCL-10 in HIV-1-associated dementia: abrogation of CXCL-10-induced neuro-glial toxicity in vitro by PKC activator

(2012) Rajeev Mehla et al.   Journal of Neuroinflammation

Zidovudine and Ursodeoxycholic Acid Conjugation: Design of a New Prodrug Potentially Able To Bypass the Active Efflux Transport Systems of the Central Nervous System

(2012) Alessandro Dalpiaz et al.   MOLECULAR PHARMACEUTICS

Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption

(2011) Y. Yao et al.   JOURNAL OF CELL SCIENCE

Toward Eradicating HIV Reservoirs in the Brain: Inhibiting P-Glycoprotein at the Blood–Brain Barrier with Prodrug Abacavir Dimers

(2011) Hilda A. Namanja et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bryostatin-1 Synergizes with Histone Deacetylase Inhibitors to Reactivate HIV-1 from Latency

(2010) Moises Perez et al.   CURRENT HIV RESEARCH

Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294

(2010) Kenichi Imai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of PKC Isoform βI at the Blood–Brain Barrier Rapidly Decreases P-Glycoprotein Activity and Enhances Drug Delivery to the Brain

(2010) Robert R Rigor et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Protein Kinase C Activation Modulates Reversible Increase in Cortical Blood–Brain Barrier Permeability and Tight Junction Protein Expression during Hypoxia and Posthypoxic Reoxygenation

(2010) Colin L Willis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Targeting of 5-aza-2′-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme

(2010) Katan Patel et al.   NUCLEIC ACIDS RESEARCH

Bryostatin Modulates Latent HIV-1 Infection via PKC and AMPK Signaling but Inhibits Acute Infection in a Receptor Independent Manner

(2010) Rajeev Mehla et al.   PLoS One

Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors

(2009) Nancie M Archin et al.   AIDS

Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid

(2009) Nancie M. Archin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Interleukin-25 Expressed by Brain Capillary Endothelial Cells Maintains Blood-Brain Barrier Function in a Protein Kinase Cϵ-dependent Manner

(2009) Yoshifumi Sonobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells

(2009) Xavier Contreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

(2009) Yanqi Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of PKCβII and PKCδ in blood–brain barrier permeability during aglycemic hypoxia

(2009) Young-Ae Kim et al.   NEUROSCIENCE LETTERS

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

(2009) Steven E. Kauder et al.   PLoS Pathogens

The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies

(2008) Birk Poller et al.   JOURNAL OF NEUROCHEMISTRY