Review
Peripheral Vascular Disease
Jun Kyoung, Rohit R. Atluri, Tao Yang
Summary: The gut microbiota plays a crucial role in drug metabolism, including antihypertensive drugs, and understanding this interaction may lead to better therapeutic outcomes. Resistant hypertension, a subset of patients with poor response to antihypertensive medications, is linked to the gut microbiota.
Article
Ecology
Chris Broeckhoven
Summary: Predation is considered important for the evolution and maintenance of dermal armour, but the strong link between predation and armour is difficult to assess. The author proposes the fighting-advantage hypothesis, suggesting that aggressive interactions with conspecifics, rather than predation, may have been a key selective pressure in the evolution of dermal armour.
JOURNAL OF ANIMAL ECOLOGY
(2022)
Review
Peripheral Vascular Disease
Stephane Laurent, Claudia Agabiti-Rosei, Rosa Maria Bruno, Damiano Rizzoni
Summary: Microcirculation and macrocirculation form a dangerous cross-link in hypertension, leading to vessel damage and elevated blood pressure. This vicious cycle can be reversed through pharmacological treatment.
Article
Multidisciplinary Sciences
Guangmei Wang, Katharina Dorn, Stefanie Siebeneichler, Martin Valldor, Volodymyr Smetana, Anja-Verena Mudring
Summary: Open framework materials like zeolites and metalorganic frameworks have attracted significant interest due to their unique structures and appealing functionalities. In this research, new inorganic framework materials were discovered, with scaffold based on octahedral transition metal building blocks instead of tetrahedral ones. These materials exhibit distinctive structural features and interesting properties.
Article
Biology
Noah J. Connally, Sumaiya Nazeen, Daniel Lee, Huwenbo Shi, John Stamatoyannopoulos, Sung Chun, Chris Cotsapas, Christopher A. Cassa, Shamil R. Sunyaev, Jonathan Flint
Summary: This study investigates the relationship between complex traits and gene expression and suggests the need for better models to explain the associations.
Article
Microbiology
Jianhua Wang, Guan-Zhu Han
Summary: In this study, a novel retrotransposon lineage called Odin retrotransposons was discovered within the genomes of sea anemones. Phylogenetic analyses showed that Odin retrotransposons were closely related to lokiretroviruses and retroviruses, providing insights into the origin and evolution of retroviruses.
Article
Nanoscience & Nanotechnology
Qi Zhong, Haoqi Zhao, Liang Feng, Kurt Busch, Sahin K. Ozdemir, Ramy El-Ganainy
Summary: Optical resonators are structures that use wave interference and feedback to control light. They can support standing- or traveling-wave modes depending on the feedback mechanism. This article introduces a new class of photonic resonators that support a hybrid optical mode, which can be implemented using chip-scale photonics and free-space optics.
Article
Chemistry, Multidisciplinary
Wei Xu, Yuuya Nagata, Naoya Kumagai
Summary: Quinoline, a neglected synthon, has been successfully synthesized as a 'missing link' in the N4 macrocycle family. The resulting TEQs possess a highly rigid saddle shape and can coordinate a series of transition-metal cations. TEQ/Fe(II) complexes show catalytic activity in dehydrogenation and oxygenation reactions with low catalyst loadings.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Environmental Sciences
Gerdien de Vries, Katharina Biely, Emile Chappin
Summary: In the next decade, transition researchers should incorporate perspectives, theories, and methods from the scientific field of psychology. An integrative research approach that spans the individual, group, and system levels, conducted in interdisciplinary research teams, is essential for more effective analysis and application of sustainability transition processes.
ENVIRONMENTAL INNOVATION AND SOCIETAL TRANSITIONS
(2021)
Review
Chemistry, Multidisciplinary
Kochurani K. Johnson, Pramod Koshy, Jia-Lin Yang, Charles C. Sorrell
Summary: Nanomaterials with cancer-imaging and therapeutic properties have been a major focus of nanotheranostics. Significant progress has been made in research and clinical applications, but careful examination and evaluation of their specific in vivo preclinical status are still needed. This is crucial for the clinical translation of nanotheranostic materials, as it helps improve understanding of their biocompatibility and therapeutic effects.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Jing-Dong J. Han
Summary: During cellular senescence and organismal aging, cells undergo molecular and morphological changes. This review focuses on the roles of long noncoding RNAs (lncRNAs) in senescence-associated nuclear architecture and morphological changes, particularly RNA double-strand DNA triplexes as a nexus between lncRNAs, DNA, and proteins. The future of deciphering direct links between lncRNA changes and nuclear morphology changes with the help of artificial intelligence and genetic perturbations is also discussed.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Khawar Sohail Siddiqui, Haluk Ertan, Anne Poljak, Wallace J. Bridge
Summary: Kinetic productivity analysis is crucial for characterizing enzyme catalytic performance and capacity, but it is often overlooked in published literature. Only a small fraction of studies provide productivity analysis, despite it being the only reliable indicator of potential commercial value. This article argues for the importance of reporting productivity data for native, modified, and immobilized enzymes under different reaction conditions to optimize enzymatic processes and accelerate biotechnological applications. Using examples from various studies, the article demonstrates the critical significance of productivity in the translational and commercial use of enzymes and the processes employing them. The article concludes by suggesting steps to maximize enzyme catalyzed reaction productivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Daniela Kalla, Krzysztof Flisikowski, Kaiyuan Yang, Laura Beltran Sanguesa, Mayuko Kurome, Barbara Kessler, Valeri Zakhartchenko, Eckhard Wolf, Heiko Lickert, Dieter Saur, Angelika Schnieke, Tatiana Flisikowska
Summary: The Cre/loxP system is essential for generating animal models with precise gene expression. While pigs may not replace mice in basic research, they offer complementary resources for translational studies. CRISPR/Cas9-mediated insertion of iCre into the porcine PTF1A gene allows for the generation of Cre-driver lines for modeling human cancers in large animals.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
N. Jannah M. Nasir, Alberto Corrias, Hans Heemskerk, Eng Tat Ang, Julia H. Jenkins, S. J. Sebastin, Lisa Tucker-Kellogg
Summary: Chronic and recurring pressure ulcers (PUs) require predictive biomarkers. This study suggests that the panniculus carnosus, thought to be vestigial in humans, might play a crucial role in the chronicity and reinjury of heel PUs.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Engineering, Industrial
Ferran Vendrell-Herrero, Yancy Vaillant, Oscar F. Bustinza, Esteban Lafuente
Summary: This study suggests that manufacturing firms selling long-lifespan products perform better in servitization, with product lifespan having a positive moderating effect on the relationship between servitization and performance. Implementing recurrent services during an extended product lifecycle provides an opportunity for BtoB solutions delivery and product usage optimization.
PRODUCTION PLANNING & CONTROL
(2022)
Article
Physiology
Sergio Brasil, Ricardo C. Nogueira, Angela S. M. Salinet, Marcia H. Yoshikawa, Manoel J. Teixeira, Wellingson Paiva, Luiz M. S. Malbouisson, Edson Bor-Seng-Shu, Ronney B. Panerai
Summary: This study found that in patients with acute brain injury, intracranial pressure (ICP) contributes less to cerebral blood flow autoregulation compared to mean arterial blood pressure (MAP). This has implications for the management of arterial blood pressure in neurocritical patients.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Review
Medicine, Research & Experimental
Wellingson Silva Paiva, Emanuele Zippo, Carolina Miranda, Sergio Brasil, Daniel Augustin Godoy, Almir Ferreira De Andrade, Iuri Neville, Gustavo Cartaxo Patriota, Renan Domingues, Manoel Jacobsen Teixeira
Summary: Intracranial hematomas (ICH) are a common condition in neurosurgical and neurological practices, and experimental research has played a fundamental role in understanding the pathophysiology and developing therapeutic interventions. Various animal models have been used to study ICH, including autologous blood or bacterial collagenase injection, inflation of intracranial balloon, and avulsion of cerebral vessels. These models have improved our understanding of intracranial hypertension, neuroinflammation, immunology, and brain hemodynamics, and have contributed to the development of therapeutic strategies.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Anesthesiology
Sergio Brasil, Gustavo Frigieri, Fabio Silvio Taccone, Chiara Robba, Davi Jorge Fontoura Solla, Ricardo de Carvalho Nogueira, Marcia Harumy Yoshikawa, Manoel Jacobsen Teixeira, Luiz Marcelo Sa Malbouisson, Wellingson Silva Paiva
Summary: This study assessed the correlation between noninvasive intracranial pressure waveforms (NICPW) and invasively measured intracranial pressure (ICP), as well as the prognostic value of NICPW in acute brain-injured patients. The results showed a significant correlation between NICPW and ICP, and the NICPW-derived P2/P1 ratio could predict intracranial hypertension and early death.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Letter
Critical Care Medicine
Gustavo Frigieri, Chiara Robba, Fabio Santana Machado, Joao A. A. Gomes, Sergio Brasil
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)
Article
Hematology
Julia Mota Leite, Tomas Zecchini Barrese, Leonardo Sementilli, Leandro Luiz Lopes de Freitas, Kleber Simoes do Espirito Santo, Marcia Torresan Delamain, Otavio Cesar Carvalho Guimaraes Baiocchi, Sergio Augusto Buzian Brasil, Carlos Sergio Chiattone
Summary: Castleman's disease (CD) is a rare lymphoproliferative disorder with limited clinical information in Brazil. A retrospective study analyzed the medical records of 44 patients between 1999 and 2020. The study found differences in age, gender, affected sites, histological forms, symptoms, and biopsy rates between unicentric and multicentric CD patients. The study also observed similarities in clinical profiles to previous literature, such as gender, age, symptoms, and treatment.
ANNALS OF HEMATOLOGY
(2023)
Article
Critical Care Medicine
Sergio Brasil, Ricardo de Carvalho Nogueira, Angela Salomao Macedo Salinet, Marcia Harumy Yoshikawa, Manoel Jacobsen Teixeira, Wellingson Paiva, Luiz Marcelo Sa Malbouisson, Edson Bor-Seng-Shu, Ronney B. Panerai
Summary: This study evaluates the effects of intracranial pressure (ICP) variability on critical closing pressure (CrCP) and resistance-area product (RAP) among patients with acute brain injury (ABI). The results show a strong correlation between changes in ICP and corresponding changes in CrCP. Patients who underwent neurosurgical interventions have elevated cerebrovascular resistance despite increased arterial blood pressure responses.
NEUROCRITICAL CARE
(2023)
Editorial Material
Endocrinology & Metabolism
Sergio Brasil, Ronney B. Panerai, Edson Bor-Seng-Shu, Ricardo C. Nogueira
Summary: Cerebral perfusion pressure (CPP), which is commonly used in neurocritical care, is calculated as the difference between mean arterial blood pressure and mean intracranial pressure. This commentary discusses recent physiological advances and bedside practice issues, suggesting that considering CPP under this perspective may lead to inaccurate assumptions and potentially misleading decision making.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Letter
Critical Care Medicine
Sergio Brasil, Juliana Caldas, Lucy Beishon, Jatinder S. Minhas, Ricardo C. Nogueira
NEUROCRITICAL CARE
(2023)
Article
Critical Care Medicine
Sergio Brasil, Hannah Romeijn, Esther K. Haspels, Wellingson Paiva, Arjen Schaafsma
Summary: This study compares the predictive value of the pulsatile apparent resistance (PaR) index versus the pulsatility index (PI) for intracranial hypertension (ICP > 20 mm Hg) in patients with traumatic brain injury. The results show that the discriminative power of PaR for discriminating intracranial hypertension was superior to PI. PaR seems to be a reliable noninvasive parameter for detecting intracranial hypertension.
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Sergio Brasil, Daniel A. Godoy, Wellingson S. Paiva
Summary: Based on recent research, intracranial pressure management based on predetermined thresholds is not accurate, and physicians need to combine other neuromonitoring techniques to comprehensively evaluate patients' neurological conditions.
WORLD NEUROSURGERY
(2023)
Letter
Clinical Neurology
Sergio Brasil, Daniel Agustin Godoy
ACTA NEUROCHIRURGICA
(2023)
Review
Critical Care Medicine
Daniel Agustin Godoy, Sergio Brasil, Corrado Iaccarino, Wellingson Paiva, Andres M. Rubiano
Summary: For decades, the management of severe acute brain injury has focused on controlling intracranial hypertension (IH). However, the thresholds for determining IH have changed over time without clear evidence. Recent developments in understanding intracranial content dynamics and monitoring techniques suggest that targeting intracranial compliance (ICC) may be a more reliable approach. This perspective review discusses the concept of intracranial compartmental syndrome (ICCS) and proposes an integrative model for assessing IH and ICC using modern invasive and noninvasive techniques.
Meeting Abstract
Critical Care Medicine
Sergio Brasil, Fabio Taccone
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
Sergio Brasil, Gustavo Frigieri, Chiara Robba, Fabio Taccone
CRITICAL CARE MEDICINE
(2023)
Article
Surgery
Maira de Robertis Azevedo, Marcelo de-Lima-Oliveira, Alessandro Rodrigo Belon, Sergio Brasil, Manoel Jacobsen Teixeira, Wellingson Silva Paiva, Edson Bor-Seng-Shu
Summary: This study aimed to determine the normal optical nerve sheath (ONS) diameter using ultrasonography (ONSUS) and evaluate the potential effects of drugs on ONS diameter during anesthetic induction in healthy pigs. The results showed that sedation with thiopental led to a significant reduction in ONS diameter compared to propofol.
ACTA CIRURGICA BRASILEIRA
(2022)
