Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Cell Biology
Zhihui Zhang, Guanghou Shui, Min-Dian Li
Summary: Meal timing can reset cellular circadian clocks in the body, with clocks in different tissues being reset to varying degrees by feeding rhythms, and modulated by the central clock and the liver clock. Tissue-specific regulation and intercellular signaling play essential roles in clock synchronization.
TRENDS IN CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tingting Li, Shihua Zhang, Yuxuan Yang, Lingli Zhang, Yu Yuan, Jun Zou
Summary: This paper reviews the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Biochemistry & Molecular Biology
Weiyun Zhang, Chi-Tang Ho, Muwen Lu
Summary: This study found that piperine improves lipid metabolism disorders in HepG2 cells by regulating the Bmal1 and Clock genes, reducing circadian desynchrony, ROS overproduction, and mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Zala Zuzek, Lucija Raspor Dall'Olio, Katka Pohar, Alojz Ihan, Miha Moskon, Damjana Rozman, Ursa Kovac, Marjanca Starcic Erjavec
Summary: Research has shown that dysbiosis of gut microbiota can affect the circadian clock of mammalian hosts, highlighting the importance of genetic background of E. coli in influencing the host's circadian clock genes.
Article
Biochemistry & Molecular Biology
Maria Savino, Claudio Carmine Guida, Maria Nardella, Emanuele Murgo, Bartolomeo Augello, Giuseppe Merla, Salvatore De Cosmo, Antonio Fernando Savino, Roberto Tarquini, Francesco Cei, Filippo Aucella, Gianluigi Mazzoccoli
Summary: This article investigates the relationship between heme biosynthesis disorders and altered expression of circadian genes, finding that changes in circadian gene expression may be associated with the symptoms and signs of porphyria patients.
Article
Multidisciplinary Sciences
Mingxu Fang, Archana G. Chavan, Andy LiWang, Susan S. Golden
Summary: In this study, the researchers used the IVC reactions and massively parallel experiments to study entrainment, the synchronization of the circadian clock with the environment. The results showed that the IVC better explains the in vivo clock-resetting phenotypes of wild-type and mutant strains, and the output components are deeply engaged with the core oscillator, affecting the way input signals entrain the core pacemaker. These findings blur the line between input and output pathways and support the previous demonstration that key output components are fundamental parts of the clock.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Behavioral Sciences
Max de Leeuw, Sanne I. Verhoeve, Nic J. A. van der Wee, Albert M. van Hemert, Erno Vreugdenhil, Claudia P. Coomans
Summary: Circadian rhythms are closely related to depression, and disruption of circadian rhythms may contribute to the development of depression. A better understanding of the connection between disturbed circadian rhythms and the etiology of depression could lead to novel therapeutic and preventative strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Annika F. Barber, Shi Yi Fong, Anna Kolesnik, Michael Fetchko, Amita Sehgal
Summary: Regulation of circadian behavior and physiology by the Drosophila brain clock requires communication from central clock neurons to downstream output regions. Morning and evening clock neurons have time-of-day-dependent connectivity to the pars intercerebralis, which is regulated by specific peptides and fast neurotransmitters. This study provides insights into mechanisms by which clock neurons signal to nonclock cells to drive rhythms of behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Li Yuan, Grace Z. Xie, Siyuan Zhang, Baozhu Li, Xianglong Wang, Yu Li, Tao Liu, Xiaodong Xu
Summary: The study investigated the role of soybean circadian clock genes in leaf water stress response, finding that the quadruple mutant had decreased leaf water loss under dehydration stress. Dehydration treatment delayed the peak expression of GmLCL genes by 4 hr, and the circadian clock in hairy roots also responded to ABA, leading to a free-running rhythm with shortened period. The findings suggest that GmLCLs act as negative regulators of ABA signaling in leaves during dehydration response.
PLANT CELL AND ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Sara M. Ortega-Campos, Eva M. Verdugo-Sivianes, Ana Amiama-Roig, Jose R. Blanco, Amancio Carnero
Summary: The molecular machinery of the circadian clock regulates gene expression and cellular activities to adapt to daily light-dark cycles. Disruption of the circadian rhythm is an independent risk factor for cancer and circadian genes may play dual roles as tumor suppressors and oncogenes. Understanding the molecular basis of the circadian clock can help identify new markers and targets for cancer prognosis and therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Multidisciplinary Sciences
Lihong Zhao, Stephanie R. R. Lundy, Francis O. O. Eko, Joeseph U. U. Igietseme, Yusuf O. O. Omosun
Summary: This study aimed to determine if the time of Chlamydia infection affects the genital tract microbiome. The results showed that mice infected in the morning had higher Chlamydia infectivity than those infected at night. The time of infection had an impact on the microbial dynamics, particularly in the upper genital tract.
SCIENTIFIC REPORTS
(2023)
Letter
Plant Sciences
James Ronald, Anthony J. Wilkinson, Seth J. Davis
Summary: The sub-nuclear localization of EARLY FLOWERING3 gene responds to changes in ambient temperature.
Article
Genetics & Heredity
Audrey Earnhardt-San, Emilie Baker, David Riley, Noushin Ghaffari, Charles Long, Rodolfo Cardoso, Ronald Randel, Thomas Welsh
Summary: This study aimed to investigate the expression differences of circadian clock genes within and among the bovine stress axis tissues. The results showed significant differences in the expression of circadian clock genes within each tissue and among different tissues. These findings are of great importance for improving livestock husbandry and welfare by understanding the interactions between the environment, stress responsiveness, and peripheral circadian rhythms.
Article
Multidisciplinary Sciences
Nisha Misra, Manohar Damara, Pierre Chambon
Summary: This article investigates the role of transcriptional regulators RevErbα, E4BP4, and CRY1/PER1 in generating circadian rhythms. Molecular and genetic analyses reveal that the chromatin protein HP1α plays a crucial role in transcriptional repressions of circadian clock genes and their output genes. The presence of HP1α is critical for chromatin compaction, formation of repressed biomolecular hydrophobic condensates, and recruitment and methylation of DNA methylating enzymes on the intronic deoxyCpG islands within the circadian output genes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Andrew R. Morris, Daniel L. Stanton, Destino Roman, Andrew C. Liu
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Article
Entomology
Timothy A. Ebert, Laura Waldo, Daniel Stanton, Arnold W. Schumann
JOURNAL OF ECONOMIC ENTOMOLOGY
(2020)
Article
Multidisciplinary Sciences
Juliana M. Soares, Kyle C. Weber, Wenming Qiu, Daniel Stanton, Lamiaa M. Mahmoud, Hao Wu, Patrick Huyck, Janice Zale, Kawther Al Jasim, Jude W. Grosser, Manjul Dutt
SCIENTIFIC REPORTS
(2020)
Article
Anatomy & Morphology
Jonathan R. Cowart, Danielle M. Collins, Daniel L. Stanton, Gerhard van Der Horst, Iskande V. Larkin
Summary: This study provides new morphometric and ultrastructural data for Florida manatee sperm, revealing unique features and potential effects of sexual selective pressures. The findings offer insights for further research on reproductive physiology and sperm competition in this species.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Manjul Dutt, Lamiaa M. Mahmoud, Karen Chamusco, Daniel Stanton, Christine D. Chase, Ethan Nielsen, Maria Quirico, Qibin Yu, Frederick G. Gmitter, Jude W. Grosser
Summary: This study successfully developed allotetraploid finger lime hybrids and cybrids, which showed HLB-negative results even after 6 years of growth in an HLB-endemic environment, with upregulation of pathogenesis related genes associated with HLB tolerance. These novel somatic fusions and cybrids could potentially serve as breeding parents for improved HLB-tolerant citrus rootstocks and scions.
Article
Multidisciplinary Sciences
Wenxiu Ma, Zhiqian Pang, Xiaoen Huang, Jin Xu, Sheo Shankar Pandey, Jinyun Li, Diann S. Achor, Fernanda N. C. Vasconcelos, Connor Hendrich, Yixiao Huang, Wenting Wang, Donghwan Lee, Daniel Stanton, Nian Wang
Summary: Huanglongbing (HLB) is a devastating disease of citrus caused by phloem-colonizing bacteria. This study provides evidence that HLB is an immune-mediated disease, characterized by an exaggerated immune response including reactive oxygen species production. The researchers also found that antioxidants and a growth-promoting hormone can mitigate disease symptoms.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Lamiaa M. Mahmoud, Prabhjot Kaur, Daniel Stanton, Jude W. Grosser, Manjul Dutt
Summary: Through the CRISPR/Cas9 system and genome editing techniques on protoplasts, we successfully integrated exogenous DNA fragments into the citrus plant genome and achieved gene editing in citrus plants by regulating the expression of the negative regulator CsNPR3 gene.
Article
Biotechnology & Applied Microbiology
Lamiaa M. Mahmoud, Daniel Stanton, Basma H. Amin, Jude W. Grosser, Manjul Dutt
Summary: In this study, it was found that overexpressing the NPR1 gene enhances salt tolerance in transgenic citrus plants by improving photosynthesis, increasing antioxidants, and maintaining cell membrane integrity.
PLANT CELL TISSUE AND ORGAN CULTURE
(2022)
Article
Microbiology
Yixiao Huang, Fanchao Zhu, Jin Koh, Daniel Stanton, Sixue Chen, Nian Wang
Summary: This study reveals that Citrus Huanglongbing (HLB) is caused by Candidatus Liberibacter asiaticus (Las) triggering immune responses rather than directly containing pathogenicity factors. The researchers used Liberibacter crescens (Lcr) as a surrogate to identify proteins of Las and discovered potential proteins that may interact with host proteins in the phloem tissues.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Plant Sciences
Kyle C. Weber, Lamiaa M. Mahmoud, Daniel Stanton, Stacy Welker, Wenming Qiu, Jude W. Grosser, Amit Levy, Manjul Dutt
Summary: The Australian finger lime has tolerance to Huanglongbing (HLB) and possesses specific redox control systems to mitigate the reactive oxygen species and modulate the plant defense response. Candidate genes responsible for resistance and better regeneration of phloem tissues in response to HLB infection have been identified. Understanding these mechanisms can aid in developing strategies to protect trees from HLB infection.
FRONTIERS IN PLANT SCIENCE
(2022)