Non-Native Anionic Ligand Binding and Reactivity in Engineered Variants of the Fe(II)- and α-Ketoglutarate-Dependent Oxygenase, SadA

Algorithm-aided engineering of aliphatic halogenase WelO5* for the asymmetric late-stage functionalization of soraphens

(2022) Johannes Büchler et al.   Nature Communications

Engineering Fe(II)/α-Ketoglutarate-Dependent Halogenases and Desaturases

(2022) Athena Papadopoulou et al.   BIOCHEMISTRY

What Drives Radical Halogenation versus Hydroxylation in Mononuclear Nonheme Iron Complexes? A Combined Experimental and Computational Study

(2022) Emilie F. Gérard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Re‐Programming and Optimization of a L ‐Proline cis ‐4‐Hydroxylase for the cis ‐3‐Halogenation of its Native Substrate

(2021) Athena Papadopoulou et al.   ChemCatChem

Halogen Transfer to Carbon Radicals by High-Valent Iron Chloride and Iron Fluoride Corroles

(2021) Geoffrey W. Farley et al.   INORGANIC CHEMISTRY

Straightforward Access to High-Performance Organometallic Catalysts by Fluoride Activation: Proof of Principle on Asymmetric Cyanation, Asymmetric Michael Addition, CO2 Addition to Epoxide, and Reductive Alkylation of Amines by Tetrahydrofuran

(2021) Alexey A. Tsygankov et al.   ACS Catalysis

Exploring the biocatalytic potential of Fe/α‐ketoglutarate dependent halogenases

(2020) Moritz Voss et al.   CHEMISTRY-A EUROPEAN JOURNAL

Determining the Inherent Selectivity for Carbon Radical Hydroxylation versus Halogenation with FeIII(OH)(X) Complexes: Relevance to the Rebound Step in Non-heme Iron Halogenases

(2020) Vishal Yadav et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants

(2020) Colin Y. Kim et al.   Nature Communications

Evidence for Modulation of Oxygen Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxoglutarate-Dependent Oxygenases

(2019) Juan Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A family of radical halogenases for the engineering of amino-acid-based products

(2019) Monica E. Neugebauer et al.   Nature Chemical Biology

Chloride Supports O2 Activation in the D201G Facial Triad Variant of Factor-Inhibiting Hypoxia Inducible Factor, an α-Ketoglutarate Dependent Oxygenase

(2018) Vanessa D. Chaplin et al.   INORGANIC CHEMISTRY

A Comparative Review on the Catalytic Mechanism of Nonheme Iron Hydroxylases and Halogenases

(2018) Amy Timmins et al.   Catalysts

Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases

(2015) Salette Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts

(2015) Christopher K. Prier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Experimental Correlation of Substrate Position with Reaction Outcome in the Aliphatic Halogenase, SyrB2

(2015) Ryan J. Martinie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multi-Enzymatic Synthesis of Optically Pure β-Hydroxy α-Amino Acids

(2014) Makoto Hibi et al.   ADVANCED SYNTHESIS & CATALYSIS

Structural optimization of SadA, an Fe(II)- and α-ketoglutarate-dependent dioxygenase targeting biocatalytic synthesis of N-succinyl-l-threo-3,4-dimethoxyphenylserine

(2014) Hui-Min Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

(2014) Megan L Matthews et al.   Nature Chemical Biology

Crystal Structure of a Novel N-Substituted L-Amino Acid Dioxygenase from Burkholderia ambifaria AMMD

(2013) Hui-Min Qin et al.   PLoS One

Beyond Directing Groups: Transition-Metal-Catalyzed CH Activation of Simple Arenes

(2012) Nadine Kuhl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatic functionalization of carbon–hydrogen bonds

(2010) Jared C. Lewis et al.   CHEMICAL SOCIETY REVIEWS

Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3

(2009) Cintyu Wong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stringency of the 2-His–1-Asp Active-Site Motif in Prolyl 4-Hydroxylase

(2009) Kelly L. Gorres et al.   PLoS One

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

(2009) M. L. Matthews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA