Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion

Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model

(2015) Amy E Gillgrass et al.   BMC CANCER

Inflammatory IL-15 is required for optimal memory T cell responses

(2015) Martin J. Richer et al.   JOURNAL OF CLINICAL INVESTIGATION

Soluble Interleukin-15 Complexes Are Generated In Vivo by Type I Interferon Dependent and Independent Pathways

(2015) Scott M. Anthony et al.   PLoS One

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking

(2014) Jeffrey C. Nolz et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional Regulation of IL-15 Expression during Hematopoiesis

(2013) S. L. Colpitts et al.   JOURNAL OF IMMUNOLOGY

Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion

(2013) Yared Hailemichael et al.   NATURE MEDICINE

Circulating IL-15 exists as heterodimeric complex with soluble IL-15R  in human and mouse serum

(2012) C. Bergamaschi et al.   BLOOD

Cutting Edge: The Role of IFN-  Receptor and MyD88 Signaling in Induction of IL-15 Expression In Vivo

(2012) S. L. Colpitts et al.   JOURNAL OF IMMUNOLOGY

The Basis of Distinctive IL-2– and IL-15–Dependent Signaling: Weak CD122-Dependent Signaling Favors CD8 + T Central-Memory Cell Survival but Not T Effector-Memory Cell Development

(2011) Iris Castro et al.   JOURNAL OF IMMUNOLOGY

Irradiation and IL-15 promote loss of CD8 T-cell tolerance in response to lymphopenia

(2010) T. Oelert et al.   BLOOD

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Early Signals during CD8+ T Cell Priming Regulate the Generation of Central Memory Cells

(2010) J. J. Obar et al.   JOURNAL OF IMMUNOLOGY

Radiation-induced cell death mechanisms

(2010) David Eriksson et al.   TUMOR BIOLOGY

IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and    T cells in vivo

(2009) J.-s. Do et al.   BLOOD

Macrophage- and Dendritic-Cell-Derived Interleukin-15 Receptor Alpha Supports Homeostasis of Distinct CD8+ T Cell Subsets

(2009) Erwan Mortier et al.   IMMUNITY

IFN-  Enhances Peptide Vaccine-Induced CD8+ T Cell Numbers, Effector Function, and Antitumor Activity

(2009) A. G. Sikora et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cells Support the In Vivo Development and Maintenance of NK Cells via IL-15 Trans-Presentation

(2009) E. F. Castillo et al.   JOURNAL OF IMMUNOLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation

(2008) S. W. Stonier et al.   BLOOD

IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response

(2008) M. P. Rubinstein et al.   BLOOD

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens

(2008) Mark E. Dudley et al.   JOURNAL OF CLINICAL ONCOLOGY

IL-15Rα chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation

(2008) Erwan Mortier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

(2008) Nicholas D. Huntington et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE