Article
Biochemistry & Molecular Biology
Xianzhu Wu, Frank Brombacher, Zissis C. Chroneos, Christopher C. Norbury, D. Channe Gowda
Summary: IL-4 is considered beneficial for protecting against severe malaria by promoting Th2 responses and inhibiting inflammation, but the timing and tissue environment of its production can also induce inflammatory responses. The study shows a paradoxical role of IL-4R alpha signaling in cerebral malaria pathogenesis by promoting inflammatory responses mediated by CD8 alpha(+) DCs, leading to damaging Th1 and cytotoxic CD8(+) T cell responses.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Leonard R. Pelgrom, Thiago A. Patente, Frank Otto, Lonneke V. Nouwen, Arifa Ozir-Fazalalikhan, Alwin J. van der Ham, Hendrik J. P. van der Zande, Graham A. Heieis, Ramon Arens, Bart Everts
Summary: This study reveals that mTORC1 limits the activation of CD8(+) T cells in vivo by regulating the metabolism and immunogenicity of different subsets of antigen-presenting cells, but it does not affect antigen-specific CD8(+) T cell responses to infection.
Article
Multidisciplinary Sciences
Martina Damo, Noah I. Hornick, Aarthi Venkat, Ivana William, Kathryn Clulo, Srividhya Venkatesan, Jiaming He, Eric Fagerberg, Jennifer L. Loza, Darwin Kwok, Aya Tal, Jessica Buck, Can Cui, Jaiveer Singh, William E. Damsky, Jonathan S. Leventhal, Smita Krishnaswamy, Nikhil S. Joshi
Summary: The presence of self-reactive T cells in the peripheral T cell repertoire of healthy individuals is influenced by checkpoint receptors like PD-1. However, the high frequency of immune-related adverse events in cancer patients treated with checkpoint inhibitors challenges this model. This study developed a mouse model to demonstrate the role of PD-1 in maintaining tissue tolerance and preventing immunopathology.
Article
Immunology
Courtney K. Anderson, Shanelle P. Reilly, Laurent Brossay
Summary: IL-12, IL-18, and TLRs are dispensable for TCR activation pathway in iNKT cells, but are essential during murine CMV infection. There is an intrinsic requirement for IL-18 signaling by splenic iNKT cells but not liver iNKT cells. The exact contributions of these components for TCR-dependent and -independent activation pathways in iNKT cells are still unclear.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Zhijuan Qiu, Camille Khairallah, Timothy H. H. Chu, Jessica N. N. Imperato, Xinyuan Lei, Galina Romanov, Amha Atakilit, Lynn Puddington, Brian S. S. Sheridan
Summary: CD8 tissue-resident memory T (T-RM) cells in barrier tissues provide frontline protection, but the mechanisms regulating their development are not completely understood. This study shows that T cell priming in the mesenteric lymph nodes (MLN) regulates the differentiation of CD103(+) T-RM cells in the intestine, while T cells primed in the spleen are impaired in this process. Licensing of differentiation is regulated by retinoic acid signaling and factors other than gut homing receptors.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ioana Alesutan, Laura A. Henze, Beate Boehme, Trang T. D. Luong, Daniel Zickler, Burkert Pieske, Kai-Uwe Eckardt, Andreas Pasch, Jakob Voelkl
Summary: Medial vascular calcification is common in CKD and is closely linked to hyperphosphatemia. This study reveals the role and mechanisms of periostin in promoting vascular smooth muscle cell calcification.
Article
Oncology
Till Braun, Johanna Stachelscheid, Nadine Bley, Sebastian Oberbeck, Moritz Otte, Tony Andreas Muller, Linus Wahnschaffe, Markus Glass, Katharina Ommer, Marek Franitza, Birgit Gathof, Janine Altmueller, Michael Hallek, Daniel Auguin, Stefan Huettelmaier, Alexandra Schrader, Marco Herling
Summary: This study reveals the association of AGO2 gene with T-cell prolymphocytic leukemia (T-PLL) and its role in enhancing TCR signaling and promoting tumor growth. The findings highlight the importance of aberrant TCR signaling and provide potential therapeutic targets for T-PLL.
Article
Multidisciplinary Sciences
Wojciech Dawicki, Hui Huang, Yanna Ma, Jennifer Town, Xiaobei Zhang, Chris D. Rudulier, John R. Gordon
Summary: CD40 signaling in DC10 plays a crucial role in promoting IL-10 expression and robust induction of tolerance, including activation of induced Treg.
Article
Multidisciplinary Sciences
Linghua Zheng, Xue Han, Sheng Yao, Yuwen Zhu, John Klement, Shirley Wu, Lan Ji, Gefeng Zhu, Xiaoxiao Cheng, Zuzana Tobiasova, Weiwei Yu, Baozhu Huang, Matthew D. Vesely, Jun Wang, Jianping Zhang, Edward Quinlan, Lieping Chen
Summary: T cell quiescence is maintained by the interaction between CD8 alpha and PILRa, preventing spontaneous activation and subsequent death of CD8(+) T cells in the absence of specific antigens.
Article
Cell Biology
Liang Cao, Eva Morgun, Samantha Genardi, Lavanya Visvabharathy, Yongyong Cui, Haochu Huang, Chyung-Ru Wang
Summary: The study reveals the critical role of METTL14-dependent m(6)A modification in iNKT cell development and function. Loss of METTL14-dependent m(6)A modification leads to reduced numbers and impaired maturation of iNKT cells, as well as decreased responsiveness to stimulation.
Article
Gastroenterology & Hepatology
Emily W. Sun, Eva W. Iepsen, Nektaria Pezos, Amanda L. Lumsden, Alyce M. Martin, Gudrun Schober, Nichole J. Isaacs, Christopher K. Rayner, Nam Q. Nguyen, Dayan de Fontgalland, Philippa Rabbitt, Paul Hollington, David A. Wattchow, Torben Hansen, Jens-Christian Holm, Alice P. Liou, V. Margaret Jackson, Signe S. Torekov, Richard L. Young, Damien J. Keating
Summary: This study revealed a previously unidentified signaling nexus in the human gastrointestinal tract involving the release of a-MSH and the activation of MC4R on L cells in an autocrine and paracrine fashion. The findings have direct implications for targeting mucosal MC4R as a treatment for human metabolic disorders.
Article
Cell Biology
Jodie Lopez, Francois Anna, Pierre Authie, Alexandre Pawlik, Min-Wen Ku, Catherine Blanc, Philippe Souque, Fanny Moncoq, Amandine Noirat, David Hardy, Wladimir Sougakoff, Roland Brosch, Francoise Guinet, Pierre Charneau, Laleh Majlessi
Summary: In this study, a strategy was devised to enhance the CD4(+) T cell response of Lentiviral vectors (LVs) by extending the LV-encoded antigens with MHC-II-associated light invariant chain. The results showed that this strategy improved the protective efficacy against Mycobacterium tuberculosis and extended the mucosal immune response.
Article
Multidisciplinary Sciences
Tae Gun Kang, Kee Woong Kwon, Kyungsoo Kim, Insuk Lee, Myeong Joon Kim, Sang-Jun Ha, Sung Jae Shin
Summary: Viral coinfection can lead to immune complications or interference with immune responses to Mycobacterium tuberculosis (Mtb) infection. This study demonstrates that viral coinfection suppresses Mtb-specific T(H)1 response through type I IFN response to the infecting virus, exacerbating tuberculosis immunopathology.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Mingxia Wang, Zailing Shang, Fei Qiao, Junhu Hei, Xueling Ma, Yana Wang
Summary: The Notch signaling pathway plays a crucial role in the development and differentiation of dendritic cells (DCs), as well as in the immune response mediated by DCs. By using inhibitors and activators of the Notch signaling pathway, the study demonstrates its regulatory effect on DC development and function, and its involvement in E. granulosus infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Carina Matos, Katrin Peter, Laura Weich, Alice Peuker, Gabriele Schoenhammer, Tobias Roider, Sakhila Ghimire, Nathalie Babl, Sonja Decking, Martina Guellstorf, Nicolaus Kroeger, Kathrin Hammon, Wolfgang Herr, Klaus Stark, Iris M. Heid, Kathrin Renner, Ernst Holler, Marina Kreutz
Summary: The study revealed a cooperative effect of ATG and vitamin D3 in regulating the production of 1,25-dihydroxyvitamin D3 in HSCT, especially important for patients receiving ATG for GvHD prophylaxis. High levels of 1,25-dihydroxyvitamin D3 early in HSCT have been shown to predict lower transplant-related mortality.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
S. A. Hosgood, A. Bagul, M. Kaushik, J. Rimoldi, R. S. Gadepalli, M. L. Nicholson
BRITISH JOURNAL OF SURGERY
(2008)
Meeting Abstract
Oncology
T. Rattay, M. Kaushik, S. Ahmed, S. Shokuhi
Article
Immunology
Hemant Jaiswal, Monika Kaushik, Rachid Sougrat, Monica Gupta, Anup Dey, Rohit Verma, Keiko Ozato, Prafullakumar Tailor
JOURNAL OF IMMUNOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Parul Kulshreshtha, Sneha Aggarwal, Hemant Jaiswal, Rakesh Bhatnagar
MOLECULAR IMMUNOLOGY
(2012)
Article
Surgery
Atul Bagul, Sarah A. Hosgood, Monika Kaushik, Michael L. Nicholson
TRANSPLANT INTERNATIONAL
(2008)
Article
Immunology
Michael L. Nicholson, Rosemary Elwell, Monika Kaushik, Atul Bagul, Sarah A. Hosgood
Article
Cell Biology
Irene Saha, Hemant Jaiswal, Richa Mishra, Hendrik J. Nel, Jaring Schreuder, Monika Kaushik, Kuldeep Singh Chauhan, Bhupendra Singh Rawat, Ranjeny Thomas, Shalin Naik, Himanshu Kumar, Prafullakumar Tailor
CELLULAR IMMUNOLOGY
(2020)
Article
Microbiology
Hemant Jaiswal, Thomas Ciucci, Hongshan Wang, Wanhu Tang, Estefania Claudio, Philip M. Murphy, Remy Bosselut, Ulrich Siebenlist
Summary: Bcl-3 plays a crucial cell-autonomous role in regulating the balance between memory and terminal effector cells during CD8(+) T cell differentiation. Underexpression of Bcl-3 leads to skewed differentiation towards terminal effector cells and decreased memory cell formation, while overexpression enhances memory precursor cell formation.
Article
Cell Biology
Kuldeep Singh Chauhan, Annesa Das, Hemant Jaiswal, Irene Saha, Monika Kaushik, Virendra Kumar Patel, Prafullakumar Tailor
Summary: Dendritic cells (DCs) are crucial in innate and adaptive immune responses. Different DC subtypes have distinct surface markers, transcriptional profiles, and functional responses. This study identified an interaction between IRF8 and BATF3, and an independent role of ID2 in cDC1 development. The study also discovered overlapping regions of occupancy by IRF8 and BATF3, and revealed the association of Pfkfb3 gene with the specific transcriptional pattern of cDC1 subtype. Additionally, the inhibition of PFKFB3 enzymatic activity affected cDC1 subtype in both in vitro and in vivo settings.
CELLULAR IMMUNOLOGY
(2022)
Article
Engineering, Manufacturing
Monika Kaushik, Jasdeep K. Dhanoa, Mukesh K. Khandelwal
Summary: A MIMO antenna covering the sub-6-GHz band with a wideband circularly polarized signal centered at 3.5 GHz is designed and manufactured. The antenna addresses challenges such as large size, circular polarization needs, channel capacity for 5G, diversity in MIMO, and mutual coupling issues. By incorporating several techniques, a small antenna size and high isolation between ports are achieved. The antenna improves channel capacity and exhibits suitable diversity characteristics. It also radiates omnidirectional patterns and offers wide beamwidth in different frequency bands. Experimental measurements validate the antenna model's performance.
IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Monika Kaushik, Jasdeep Kaur Dhanoa, Mukesh Kumar Khandelwal
Summary: A highly miniaturized meander line based two-port MIMO antenna is proposed for UHF RFID and Wideband applications. The antenna elements are placed orthogonal to each other to achieve high isolation and a defected ground structure with rectangular slots-shaped structures is used to improve impedance bandwidth. Various diversity characteristics performance parameters are analyzed to justify the proposed antenna as a MIMO antenna.
2021 IEEE INTERNATIONAL CONFERENCE ON RFID TECHNOLOGY AND APPLICATIONS (RFID-TA)
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Prafullakumar Tailor, Irene Saha, Hemant Jaiswal, Jaring Schreuder, Monika Kaushik, Shalin Naik, Kuldeep Singh Chauhan
