Journal
FUTURE ONCOLOGY
Volume 18, Issue 32, Pages 3667-3675Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2022-0081
Keywords
advanced; recurrent non-small-cell lung cancer; efficacy; meta-analysis; nivolumab; safety
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Nivolumab has shown improved efficacy in the treatment of advanced/recurrent NSCLC, but it also increases the risk of immune-related adverse events. Combination therapy with nivolumab is superior to monotherapy, and its efficacy is not correlated with PD-L1 expression levels.
Aim: To evaluate the efficacy and safety of nivolumab for advanced/recurrent non-small-cell lung cancer (NSCLC). Methods: Electronic databases were searched, and a systematic evaluation was performed. Results: Seven phase III randomized controlled trials and 4705 patients were included. Nivolumab improved overall survival, progression-free survival and overall response rate for advanced/recurrent NSCLC. The efficacy of nivolumab was not correlated with PD-L1 expression levels. Nivolumab combination therapy was superior to nivolumab monotherapy. NSCLC patients may benefit from nivolumab in both first-line and second-line treatment. Nivolumab did not enhance the risk of commonly reported adverse events such as fatigue, hepatotoxicity and gastrointestinal events, but enhanced the risk of immune-related adverse events. Nivolumab-associated pneumonitis is a concern. Conclusion: Nivolumab showed improved efficacy for advanced/recurrent NSCLC but increased the risk of immune-related adverse events.
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