Article
Radiology, Nuclear Medicine & Medical Imaging
E. Guedj, J. Y. Campion, P. Dudouet, E. Kaphan, F. Bregeon, H. Tissot-Dupont, S. Guis, F. Barthelemy, P. Habert, M. Ceccaldi, M. Million, D. Raoult, S. Cammilleri, C. Eldin
Summary: In long COVID patients, brain PET scans showed significant hypometabolism in areas including bilateral rectal/orbital gyrus, temporal lobe, brainstem, and cerebellum. These metabolic abnormalities were associated with more functional complaints such as hyposmia/anosmia, memory/cognitive impairment, pain, and insomnia. The study suggests a potential biomarker value in identifying and monitoring long COVID patients, with implications for the impact of ACE drugs and nasal decongestant spray on brain metabolism.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreia Rocha, Bruna Bellaver, Debora G. Souza, Guilherme Schu, Igor C. Fontana, Gianina T. Venturin, Samuel Greggio, Fernanda U. Fontella, Manoela L. Schiavenin, Luiza S. Machado, Diogo Miron, Jaderson C. da Costa, Pedro Rosa-Neto, Diogo O. Souza, Luc Pellerin, Eduardo R. Zimmer
Summary: This study used FDG-PET imaging to investigate the impact of the antipsychotic drug clozapine on brain glucose metabolism in rats, and found that downregulation of GLT-1 resulted in astrocyte-dependent cortical hypometabolism, resembling the hypometabolic signature observed in people developing dementia.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Clinical Neurology
Anita Nitchingham, Jarett Vanz-Brian Pereira, Eva A. Wegner, Vincent Oxenham, Jacqueline Close, Gideon A. Caplan
Summary: In this study, using FDG-PET, researchers found that patients with delirium showed hypometabolism in the bilateral thalami and certain cortical regions. The hypometabolism was correlated with delirium severity and performance on neuropsychological testing.
ALZHEIMERS & DEMENTIA
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
E. Guedj, M. Million, P. Dudouet, H. Tissot-Dupont, F. Bregeon, S. Cammilleri, D. Raoult
Summary: Several brain complications have been reported in COVID-19 patients, suggesting potential neurotropism and delayed outbreak of neuroinflammatory diseases. PET metabolism analysis showed hypometabolism in the olfactory/rectus gyrus and other brain regions, supporting the neurotropism hypothesis. Further post-viral cohort studies are needed to determine the exact relationship between these hypometabolisms and persistent disorders.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Abarnaa Sivapathasundaram, Nicolas Golse, Alina Pascale, Emmanuel Durand, Mylene Sebagh, Florent L. Besson
Summary: Contrary to common belief, F-18-FDG/F-18-choline dual-tracer PET behavior is not a relevant surrogate of tumor differentiation in hepatocellular carcinoma (HCC). Future multitracer PET studies are necessary to improve our understanding of their biological significance in this field.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Agathe Chammas, Izzie Jacques Namer, Francois Lersy, Stephane Kremer, Caroline Bund
Summary: A 64-year-old man presented with confusion during COVID-19 infection, with FDG PET showing high glucose metabolism and perfusion in the inferior colliculi. Brain MRI revealed no morphological abnormalities.
CLINICAL NUCLEAR MEDICINE
(2021)
Review
Oncology
Domenico Albano, Giorgio Treglia, Francesco Dondi, Anna Calabro, Alessio Rizzo, Salvatore Annunziata, Luca Guerra, Silvia Morbelli, Alessandra Tucci, Francesco Bertagna
Summary: The new biomarker Dmax, which measures the maximal distance between the two farthest hypermetabolic PET lesions, has shown high accuracy as a prognostic factor in lymphoma patients. Most studies have demonstrated the significant predictive value of Dmax in predicting progression-free survival and overall survival.
Article
Radiology, Nuclear Medicine & Medical Imaging
Christine Bastin, Mohamed Ali Bahri, Claire Bernard, Roland Hustinx, Eric Salmon
Summary: The study investigated whether patients with behavioral variant of neurocognitive disorder (bvNCD) who did not meet all criteria for bvFTD exhibited characteristic brain metabolic patterns using F-18-FDG PET. Results showed no significant differences between the two groups initially, but after 4.8 years of follow-up, most probable bvFTD patients maintained their diagnosis while some bvNCD patients showed progression towards bvFTD criteria, indicating frontal hypometabolism in bvNCD that did not meet all clinical criteria for bvFTD.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sang Woo Lee, Seong-Jang Kim
Summary: The systematic review and meta-analysis showed that F-18-FDG PET/CT has good diagnostic performance in detecting lymph node metastasis in penile cancer patients, with similar accuracy in detecting inguinal and pelvic lymph node metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
David J. Liesker, Stijn Legtenberg, Paola A. Erba, Andor W. J. M. Glaudemans, Clark J. Zeebregts, Jean-Paul P. M. De Vries, Nabil Chakfe, Ben R. Saleem, Riemer H. J. A. Slart
Summary: This study aimed to assess the variability of [F-18]FDG-PET/LDCT reporting in suspected VGEI using a standardized reporting format. The results showed that less than half of the reports met all the pre-selected criteria, and the incompleteness of reports led to lower sensitivity and specificity.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aurelie Morand, Jacques-Yves Campion, Anne Lepine, Emmanuelle Bosdure, Lea Luciani, Serge Cammilleri, Brigitte Chabrol, Eric Guedj
Summary: Despite lower initial severity at the acute stage of infection, pediatric patients with suspected long COVID showed a similar brain hypometabolic pattern as adult long COVID patients approximately 5 months later, involving bilateral medial temporal lobes, brainstem, cerebellum, and the right olfactory gyrus.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Neuroimaging
Giulia Carli, Cecilia Boccalini, Giovanna Vanoli, Massimo Filippi, Sandro Iannaccone, Giuseppe Magnani, Daniela Perani
Summary: The study found a relationship between education level and brain metabolic connectivity in Dementia with Lewy Bodies, with higher educated patients showing increased connectivity in certain brain networks. High scores on the occupation scale were associated with decreased connectivity in specific brain networks.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Clinical Neurology
Giacomo Tondo, Giulia Carli, Roberto Santangelo, Maria Vittoria Mattoli, Luca Presotto, Massimo Filippi, Giuseppe Magnani, Sandro Iannaccone, Chiara Cerami, Daniela Perani
Summary: In a large cohort of aMCI subjects, using in vivo biomarkers such as cerebrospinal fluid measures and [F-18]fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging can accurately predict the prognosis of patients. The specific [F-18]FDG-PET limbic-predominant hypometabolism pattern is associated with clinical stability and low likelihood of progression to Alzheimer's disease, providing important implications for prognosis and clinical trial planning.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Cecilia Boccalini, Giulia Carli, Andrea Pilotto, Alessandro Padovani, Daniela Perani
Summary: This study found that male PD patients exhibited widespread connectivity alterations in the nigro-striato-cortical network and preservation of the mesolimbic pathway, while female PD patients showed severe connectivity abnormalities in the mesolimbic network and only partial reconfiguration of the nigro-striato-cortical network.
BRAIN CONNECTIVITY
(2021)
Review
Neurosciences
Giulia Carli, Giacomo Tondo, Cecilia Boccalini, Daniela Perani
Summary: PET imaging allows for in vivo assessment of early brain functional and molecular changes in neurodegenerative conditions, offering a unique tool in diagnostic workup. The increased use of multivariate PET analysis approaches in the past decade has provided opportunities to study interactions between regional molecular processes and long-distance brain circuit functional interactions. PET metabolic and neurotransmission connectome can reveal interactions among brain regions.
Article
Neuroimaging
Luca Beretta, Giulia Carli, Paolo Caffarra, Daniela Perani
Summary: This study examined the neuroanatomical substrates of performance in the ROCF-c task in patients with DLB and AD. Results indicate that DLB patients performed worse in visuo-constructive tasks, while AD patients performed worse in verbal memory tasks. The distinct brain dysfunctions in DLB and AD may lead to altered visuoperceptual and visuospatial processes, respectively.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Clinical Neurology
Silvia Paola Caminiti, Giulia Carli, Micol Avenali, Fabio Blandini, Daniela Perani
Summary: The study demonstrates that PD patients with GBA mutations show more severe deficits in cognition and motor function, with more significant damage in the striatal and extra-striatal regions observed on I-123-FP-CIT imaging. Both GBA-PD and late-iPD patients exhibit global cognitive deterioration, while the early-iPD group maintains cognitive stability over time. Over the course of follow-up, the iPD cohorts show a similar reduction in I-123-FP-CIT SUVr to the GBA-PD group.
MOVEMENT DISORDERS
(2022)
Article
Behavioral Sciences
Cecilia Boccalini, Giulia Carli, Giacomo Tondo, Cristina Polito, Eleonora Catricala, Valentina Berti, Valentina Bessi, Sandro Sorbi, Sandro Iannaccone, Valentina Esposito, Stefano F. Cappa, Daniela Perani
Summary: In the semantic variant of Primary Progressive Aphasia (sv-PPA), there are extensive brain metabolic connectivity reorganization and functional alterations, particularly affecting frontal, temporal, and parietal regions. Compared to healthy controls, sv-PPA patients show functional isolation of the left anterior temporal lobe, decreased connections in temporo-occipital regions and contralateral homologous regions, increased connectivity to the dorsal parietal cortex from the spared posterior temporal cortex, and disruption of large-scale limbic brain networks. The severe functional derangement of the left anterior temporal lobe in sv-PPA may lead to extensive connectivity reconfiguration involving multiple brain regions.
Article
Neurosciences
Cecilia Boccalini, Giulia Carli, Andrea Pilotto, Alessandro Padovani, Daniela Perani
Summary: This study investigated the impact of gender differences on clinical features, dopaminergic dysfunction, and connectivity in patients with Parkinson's disease across different clinical subtypes. Results showed that males and females with idiopathic PD exhibit distinct vulnerabilities and disease expressions, particularly in cognitive function, anxiety symptoms, and dopaminergic binding patterns in different brain regions.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Cecilia Boccalini, Elisa Bortolin, Giulia Carli, Andrea Pilotto, Andrea Galbiati, Alessandro Padovani, Luigi Ferini-Strambi, Daniela Perani
Summary: Using a brain metabolic connectivity approach, this study investigates the changes in large-scale networks across the Lewy Bodies disorders spectrum. The findings show that metabolic connectivity alterations are present in the early stage of REM sleep behavior disorder, resembling the changes seen in Dementia with Lewy Bodies, while Parkinson's disease mainly affects motor and somatosensory networks.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Cecilia Boccalini, Giulia Carli, Emilia Giovanna Vanoli, Antoniangela Cocco, Alberto Albanese, Valentina Garibotto, Daniela Perani
Summary: This study investigates the effects of manual and semi-automatic methods for assessing MIBG semi-quantitative indices in a clinical setting. The results show that the semi-automatic method is superior to the manual method in terms of inter-rater agreement, especially for inexperienced readers. This has important implications for the semi-quantitative assessment of I-123-MIBG images in clinical routine.
FRONTIERS IN MEDICINE
(2022)
Article
Neurosciences
Giada D'Este, Francesca Berra, Giulia Carli, Caterina Leitner, Sara Marelli, Marco Zucconi, Francesca Casoni, Luigi Ferini-Strambi, Andrea Galbiati
Summary: Isolated rapid-eye-movement sleep behaviour disorder (iRBD) is considered a prodrome of alpha-synucleinopathies, but its progression timing varies widely. This study found that iRBD patients with higher levels of cognitive reserve (CR) had lower rates of mild cognitive impairment and better performance in visuo-constructive and verbal memory functions. These findings suggest that CR may help iRBD patients cope with cognitive decline and could be a protective factor in this condition.
Article
Radiology, Nuclear Medicine & Medical Imaging
Giulia K. Carli, Sanne Meles, Annette Janzen, Elisabeth V. Sittig, Rosalie Kogan, Daniela H. Perani, Wolfgang L. Oertel, Klaus Leenders
Summary: A study investigated the regional brain changes in isolated REM sleep behavior disorder (iRBD) patients over time and their relationship to phenoconversion. The findings suggest that occipital hypometabolism at baseline in iRBD implies a short-term conversion to Parkinson's disease (PD).
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Neurosciences
Giulia Carli, Marco Cavicchioli, Anna Lisa Martini, Matteo Bruscoli, Antonella Manfredi, Luca Presotto, Christian Mazzeo, Stelvio Sestini, Daniela Perani
Summary: This study investigates the neurobiological mechanisms underlying the comorbidity of attention-deficit hyperactivity disorder (ADHD) and cocaine use disorder (CoUD), supporting the self-medication hypothesis (SMH). The findings provide important clinical implications for treatment approaches in adults with ADHD-CoUD and suggest considering stimulant pharmacological treatments as the first line of intervention. The study is rated with a score of 8 out of 10 for its significance.
BRAIN CONNECTIVITY
(2023)
Article
Neuroimaging
Giulia Carli, Sanne K. Meles, Fransje E. Reesink, Bauke M. de Jong, Andrea Pilotto, Alessandro Padovani, Andrea Galbiati, Luigi Ferini-Strambi, Klaus L. Leenders, Daniela Perani
Summary: This study compared the use of univariate Statistical Parametric Mapping (SPM) and multivariate Scaled Subprofile Model/Principal Component Analysis (SSM/PCA) for analyzing brain metabolism patterns in patients with a-synucleinopathies. The results showed that SPM's visual rating method had higher accuracy in identifying the brain metabolism characteristics of a-synucleinopathies.
NEUROIMAGE-CLINICAL
(2023)