Article
Chemistry, Analytical
Oldrich Vysata, Ondrej Tupa, Ales Prochazka, Rafael Dolezal, Pavel Cejnar, Aprajita Milind Bhorkar, Ondrej Dostal, Martin Valis
Summary: The study compares different data reduction methods and classification methods for clinical use. The best accuracy achieved is 98% by a random forest classifier preprocessed by t-distributed stochastic neighbour embedding.
Article
Rheumatology
Oh Chan Kwon, Min-Chan Park
Summary: This study determined the cut-off values of BASDAI for determining disease activity states in ankylosing spondylitis patients. The study found that BASDAI values of 1.9, 3.5, and 4.9 corresponded to ASDAS-CRP values of 1.3, 2.1, and 3.5, respectively. The agreement between disease activity states based on BASDAI and ASDAS-CRP cut-off values was good.
Article
Clinical Neurology
He Zhou, Hung Nguyen, Ana Enriquez, Louie Morsy, Michael Curtis, Timothy Piser, Christopher Kenney, Christopher D. Stephen, Anoopum S. Gupta, Jeremy D. Schmahmann, Ashkan Vaziri
Summary: The study utilized wearable sensors to objectively measure motor impairment in SCA patients during gait and balance assessments, distinguishing them from healthy controls. Linear regression models demonstrated moderate-to-strong correlation with SARA and BARS2 scores.
NEUROLOGICAL SCIENCES
(2022)
Article
Physics, Particles & Fields
Jarah Evslin, Andrew B. Royston, Baiyang Zhang
Summary: We investigate the regularization of the one-kink sector Hamiltonian and find that it is not regularized by an energy cutoff. Instead, the field decomposition into normal mode operators yields coefficients constrained to become small for energies above the cutoff. This explains the incorrect one-loop kink mass observed when applying an energy cutoff to the kink Hamiltonian. To resolve this, we impose the condition that the regularized kink sector Hamiltonian is unitarily equivalent to the regularized vacuum sector Hamiltonian, guaranteeing the correct kink mass.
JOURNAL OF HIGH ENERGY PHYSICS
(2023)
Article
Clinical Neurology
K. J. Schouwstra, S. S. Polet, S. Hbrahimgel, A. S. Tadema, J. G. M. Burgerhof, R. Brandsma, D. A. Sival
Summary: In this study, we investigated the feasibility and reliability of using SARA scores to assess ataxia in typically developing toddlers. We found that SARA scores were age-dependent, but after making age-related compensations and allowing video recordings at home, the scores were fully reliable in all toddlers. The mathematical age connection of SARA scores revealed a continuous decreasing trend until 16 years of age. This data enables longitudinal quantification and interpretation of ataxia scores in children with early onset ataxia.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2022)
Article
Neurosciences
Marcus Grobe-Einsler, Arian Taheri Amin, Jennifer Faber, Hartmut Voelkel, Matthis Synofzik, Thomas Klockgether
Summary: A training and certification tool for the Scale for Assessment and Rating of Ataxia (SARA) was developed to provide standardized training material and reduce variability in assessing ataxia severity. The tool includes tutorial and training videos, as well as optional certification, aiming to improve patient care and research quality in ataxia.
Article
History & Philosophy Of Science
Lina Maria Lissia
Summary: This article shows the similarity between the Lottery Paradox and the Sorites, and argues that our perception of the Paradox should be modified. The Cut-off Point Problem is highlighted as a key aspect in the debate on Kyburg's puzzle. The consequences of different approaches to resolving the Lottery Paradox in relation to the Cut-off Point Problem are explored, with the heap variant of the Paradox being particularly relevant in evaluating solutions. The debate on the validity of modus ponens is also shown to be important in discussions on the Lottery Paradox.
Article
Urology & Nephrology
Francisco Maduell, Jose Jesus Broseta, Diana Rodriguez-Espinosa, Jimena del Risco, Lida Maria Rodas, Marta Arias-Guillen, Manel Vera, Nestor Fontsere, Maria del Carmen Salgado, Nayra Rico
Summary: This study compared the clinical efficacy and safety of four new medium cut-off dialyzers with other dialysis modalities. The results showed that all four dialyzers had similar effectiveness in reducing different molecular weight molecules and albumin loss. Expanded hemodialysis was found to have better efficacy than high-flux hemodialysis but was still inferior to hemodiafiltration, with no safety concerns.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Energy & Fuels
Mohammad Zeyghami, Mohammad Taghizadeh Sarvestani
Summary: The main objective of net pay determination is to exclude non-reservoir intervals so that better results are obtained in reservoir characterization, hydrocarbon in-place calculations, and dynamic flow simulation. This study presents different methods for net pay determination, their strengths, limitations, and input data, along with a new procedure. The proposed methodology considers both rock and fluid properties and validates the results.
JOURNAL OF PETROLEUM EXPLORATION AND PRODUCTION TECHNOLOGY
(2023)
Article
Clinical Neurology
Gilles Naeije, Antonin Rovai, Virginie Destrebecq, Nicolas Trotta, Xavier De Tiege
Summary: This study aimed to investigate the effects of anodal cerebellar transcranial direct current stimulation (ctDCS) on ataxic and cognitive symptoms in individuals with Friedreich's ataxia (FRDA) and the activity of the secondary somatosensory (SII) cortex. Results showed that anodal ctDCS significantly improved the assessment and rating of ataxia and cerebellar cognitive affective syndrome scale in FRDA patients, while also reducing functional magnetic resonance imaging signal in the SII cortex. This study provides evidence that ctDCS stimulation is effective and safe in treating FRDA.
MOVEMENT DISORDERS
(2023)
Article
Microbiology
Quentin Jehanne, Lucie Benejat, Astrid Ducournau, Emilie Bessede, Philippe Lehoursa
Summary: Aliarcobacter butzleri is an emerging gastrointestinal pathogen. This study analyzed the genomes of 30 resistant A. butzleri isolates to propose specific epidemiological cut-off values for certain antibiotics. The findings contribute to the development of a consensus for antimicrobial susceptibility testing for this pathogen.
MICROBIOLOGY SPECTRUM
(2022)
Article
Automation & Control Systems
Benny Avelin, Anders Karlsson
Summary: We explore the dynamical and geometrical aspects of deep learning. By quantifying differences between data or decision functions, we present semi-invariant metrics that are applicable to many standard choices of layer maps. By considering random layer maps and employing non-commutative ergodic theorems, we are able to deduce the existence of certain limits as the number of layers tends to infinity. Additionally, we investigate the random initialization of standard networks and discover a surprising cutoff phenomenon in terms of the depth of the network. This cutoff phenomenon may be an important parameter for choosing an appropriate number of layers or a good initialization procedure. In conclusion, we hope that the concepts and results in this paper can provide a geometric framework for the theoretical understanding of deep neural networks.
JOURNAL OF MACHINE LEARNING RESEARCH
(2022)
Article
Meteorology & Atmospheric Sciences
Thando Ndarana, Tsholanang S. Rammopo, Mary-Jane Bopape, Chris J. C. Reason, Hector Chikoore
Summary: By analyzing 39 years of ECMWF renalysis data, this study has shown that South African cut-off low (COL) pressure systems are preceded by downstream development of a baroclinic wave, with two energy centers evolving in different latitudinal regions. The upstream eddy kinetic energy center grows through baroclinic conversion, while the downstream center receives energy through ageostrophic geopotential fluxes induced by Rossby wave breaking. This downstream energy transfer connects South African COLs to midlatitude processes.
ATMOSPHERIC RESEARCH
(2021)
Article
Clinical Neurology
Francien A. Vogelaar, Rick Brandsma, Natasha M. Maurits, Deborah A. Sival
Summary: This study aimed to investigate the applicability of semi-quantitative eye movement assessment by ICARSOCM and OMS7-10 complementary to SARA measurements in children. Results showed that ICARS(OCM) has a valid construct for the measurement of coordinated eye movement performance in children and a similar age-dependent relationship as other ataxia subscales.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2021)
Article
Materials Science, Multidisciplinary
Guolong Jin, Haoqing Xu, Aizhao Zhou, Pengming Jiang
Summary: The study found that the porosity of soil-bentonite mixtures is affected by the bentonite content, with a critical bentonite content where the porosity is the lowest; as the bentonite content increases, the bound water percentage of the mixtures also increases.
Article
Neurosciences
Marcus Grobe-Einsler, Horst Urbach, Sebastian Paus
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Article
Clinical Neurology
Marcus Grobe-Einsler, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Heike Jacobi, Tanja Schmitz-Hubsch, Alhassane Diallo, Sophie Tezenas du Montcel, Thomas Klockgether
Summary: The study developed a video-based tool called SARA(home) for measuring ataxia severity at home, which was highly correlated with the conventional SARA. The feasibility of independent home recordings was demonstrated, showing a considerable degree of intraindividual variability in SARA(home) scores.
MOVEMENT DISORDERS
(2021)
Letter
Clinical Neurology
Andreas Traschuetz, Astrid D. Adarmes-Gomez, Mathieu Anheim, Jonathan Baets, Bjoern H. Falkenburger, Janina Gburek-Augustat, Sarah Doss, Christoph Kamm, Peter Klivenyi, Marcus Grobe-Einsler, Thomas Klopstock, Martina Minnerop, Alexander Muenchau, Chiara Pane, Mathilde Renaud, Filippo M. Santorelli, Ludger Schoels, Dagmar Timmann, Stefan Vielhaber, Tobias B. Haack, Bart P. van de Warrenburg, Ginevra Zanni, Matthis Synofzik
MOVEMENT DISORDERS
(2023)
Article
Medicine, General & Internal
Louisa Nitsch, Stefan Felix Ehrentraut, Marcus Grobe-Einsler, Felix J. Bode, Mohammed Banat, Matthias Schneider, Felix Lehmann, Julian Zimmermann, Johannes Weller
Summary: Community-acquired bacterial meningitis is a serious disease that can lead to severe complications and death. This study investigated the diagnostic performance of cerebrospinal fluid (CSF) parameters for sepsis in patients with community-acquired bacterial meningitis.
Article
Health Care Sciences & Services
M. Grobe-Einsler, J. Faber, A. Taheri, J. Kybelka, J. Raue, J. Volkening, F. Helmhold, M. Synofzik, T. Klockgether
Summary: Ataxias refer to a group of movement disorders, characterized by progressive loss of balance, impaired coordination, and speech disturbance, resulting in a significant reduction in quality of life. Although speech disturbance can be clinically diagnosed, there is a lack of objective methods for assessing its severity. Through the analysis of 71 sets of speech recordings from ataxia patients, an automated classification system was developed. This system correctly predicted the expert ratings of speech disturbance in 80% of cases, demonstrating the feasibility of computer-assisted voice analysis for automated assessment of speech disturbance severity.
NPJ DIGITAL MEDICINE
(2023)
Article
Clinical Neurology
Arian Taheri Amin, Jennifer Faber, Demet Onder, Okka Kimmich, Matthis Synofzik, Tetsuo Ashizawa, Thomas Klockgether, Marcus Grobe-Einsler
Summary: After conducting comprehensive SARA assessments on video recordings of 69 patients with cerebellar ataxia, it was found that there was a high level of agreement between live ratings by site investigators and remote video ratings by experienced ataxia clinicians, indicating that remote video ratings are a reliable means to assess the severity of ataxia.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Marcus Grobe-Einsler, Oliver Kaut
NEUROLOGICAL RESEARCH AND PRACTICE
(2020)
