A gain‐of‐function GRIA2 variant associated with neurodevelopmental delay and seizures: Functional characterization and targeted treatment

De novo missense mutation in GRIA2 in a patient with global developmental delay, autism spectrum disorder, and epileptic encephalopathy

(2022) Maeson S Latsko et al.   Cold Spring Harbor Molecular Case Studies

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

(2021) Kasper B. Hansen et al.   PHARMACOLOGICAL REVIEWS

Case Report: A Novel De Novo Missense Mutation of the GRIA2 Gene in a Chinese Case of Neurodevelopmental Disorder With Language Impairment

(2021) Bingbo Zhou et al.   Frontiers in Genetics

Auxiliary proteins are the predominant determinants of differential efficacy of clinical candidates acting as AMPA receptor positive allosteric modulators

(2020) Toshiyuki Ishii et al.   MOLECULAR PHARMACOLOGY

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

(2019) Vincenzo Salpietro et al.   Nature Communications

Perampanel and decanoic acid show synergistic action against AMPA receptors and seizures

(2018) Katrin Augustin et al.   EPILEPSIA

The AMPA Receptor Code of Synaptic Plasticity

(2018) Graham H. Diering et al.   NEURON

Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation

(2017) Ian D. Coombs et al.   Cell Reports

Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs

(2016) Maria V. Yelshanskaya et al.   NEURON

Clinical experience with adjunctive perampanel in adult patients with uncontrolled epilepsy: A UK and Ireland multicentre study

(2016) Emily Shah et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Seizure control by decanoic acid through direct AMPA receptor inhibition

(2015) Pishan Chang et al.   BRAIN

Adverse effects and safety profile of perampanel: A review of pooled data

(2014) Fergus Rugg-Gunn   EPILEPSIA

Regional Diversity and Developmental Dynamics of the AMPA-Receptor Proteome in the Mammalian Brain

(2014) Jochen Schwenk et al.   NEURON

Discovery of 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (Perampanel): A Novel, Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid (AMPA) Receptor Antagonist

(2012) Shigeki Hibi et al.   JOURNAL OF MEDICINAL CHEMISTRY

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Synaptic AMPA Receptor Plasticity and Behavior

(2009) Helmut W. Kessels et al.   NEURON

Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach

(2009) Wei Lu et al.   NEURON

A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy

(2008) Elizabeth G. Neal et al.   EPILEPSIA