Article
Pharmacology & Pharmacy
Nurdan Sena Degirmenci, Merve Uslu, Oguz Kaan Krbas, Fikrettin Sahin, Evren Onay Uar
Summary: Exosomes, as natural vesicle nanocarriers, have the advantages of biocompatibility, natural form, high stability, and low toxicity. Loading chemotherapeutic drugs into exosomes derived from non-cancerous cells can enhance the effectiveness of drug treatment without interfering with the drug's mechanism of action.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Barbara Carrese, Chiara Cavallini, Gennaro Sanita, Paolo Armanetti, Brigida Silvestri, Gaetano Cali, Giulio Pota, Giuseppina Luciani, Luca Menichetti, Annalisa Lamberti
Summary: Hybrid nanomaterials with silver seeds show promising results for molecular imaging and therapeutic applications, especially in enhancing cytotoxic activity at lower drug doses. This integrated photothermal chemotherapy approach has the potential to reduce adverse side effects of chemotherapy in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Vijay Sagar Madamsetty, Shima Tavakol, Saeid Moghassemi, Arezoo Dadashzadeh, John D. Schneible, Iman Fatemi, Abdolsamad Shirvani, Ali Zarrabi, Fereshteh Azedi, Ali Dehshahri, Abbas Aghaei Afshar, Kian Aghaabbasi, Abbas Pardakhty, Reza Mohammadinejad, Prashant Kesharwani
Summary: Breast cancer is a highly deadly neoplastic disease with limited efficacy in existing treatment methods, prompting a search for new remedies. Nanotechnology has shown promise in the field, particularly with chitosan as a potential carrier for anticancer drugs. Further research is ongoing to explore the therapeutic and diagnostic applications of chitosan in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Asghar Narmani, Saeid Ganji, Maryam Amirishoar, Roghayyeh Jahedi, Mohammad Saeed Kharazmi, Seid Mahdi Jafari
Summary: A novel targeted chitosan-based nanocarrier was developed for delivering sorafenib to lung cancer cells, showing controlled and pH-sensitive drug release. MTT assay demonstrated high cytotoxicity in cancer cells but low toxicity in normal cells. qRT-PCR revealed upregulation of Caspase9 and P53 genes and downregulation of Bcl2 gene after treatment with the nanocarrier. Cell cycle arrest and apoptosis assays confirmed the effectiveness of the nanocarrier in inducing apoptosis in cancer cells. Evaluation of internalization showed high uptake of the nanocarrier in cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Yan Zou, Yajing Sun, Yibin Wang, Dongya Zhang, Huiqing Yang, Xin Wang, Meng Zheng, Bingyang Shi
Summary: Researchers have developed a novel nanomedicine that combines cancer cell-mitochondria hybrid membrane with Gboxin-loaded nanoparticles. This nanomedicine shows promising anti-tumor responses in glioblastoma models, with improved blood circulation, tumor accumulation, and targeting capabilities.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Nadar Manimaran Vinita, Umapathy Devan, Sabapathi Durgadevi, Selvaraj Anitha, Dhamodharan Prabhu, Sundarraj Rajamanikandan, Muthusamy Govarthanan, Ananthanarayanan Yuvaraj, Muniyandi Biruntha, Arockiam Antony Joseph Velanganni, Jeyaraman Jeyakanthan, Pitchan Arul Prakash, Mohamed Sultan Mohamed Jaabir, Ponnuchamy Kumar
Summary: This study reports the use of gold nanotriangles (AuNTs) with anionic and cationic surface charge conjugating triphenylphosphonium (TPP) for targeting breast cancer cells with 5-aminoleuvinic acid (5-ALA) based photodynamic therapy (PDT). The optimized surface charge of AuNTs can kill breast cancer cells, and when combined with 5-ALA and PDT, the cationic AuNTs with TPP show improved cellular toxicity and induce mitochondrial dependent apoptosis. These findings demonstrate that cationic AuNTs with TPP can selectively target breast cancer cells in the presence of 5-ALA and PDT.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Applied
Mahmoud Gharbavi, Behrooz Johari, Romina Mozafari Tabar, Ali Sharafi
Summary: This study aimed to enhance the delivery and efficacy of the anticancer drug tamoxifen by encapsulating it in bovine serum albumin nanoparticles and hybridizing them with selenium nanoparticles. The developed nanostructures were successfully characterized, and their impact on cancer cells was evaluated. The results showed that the hybrid nanostructures exhibited higher cytotoxicity and apoptosis-inducing ability compared to other formulations. These findings highlight the importance of using BSA nanoparticles as drug carriers and their combination with selenium nanoparticles to improve therapeutic effects.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sherif Ashraf Fahmy, Soad Nasr, Asmaa Ramzy, Abdelhameed S. Dawood, Anwar Abdelnaser, Hassan Mohamed El-Said Azzazy
Summary: Loading ascorbic acid (AA) and geranium oil (GO) into niosomal nanovesicles can improve their physicochemical properties and enhance their cytotoxic effects on breast cancer cells. The AA-GO niosomal vesicles showed higher inhibitory effects on cancer cell growth and induced apoptosis compared to free AA or GO, suggesting their potential as a treatment strategy for breast cancer.
Article
Medicine, Research & Experimental
Xiangjun Chen, Mingyi Hou, Xinzhong Zhang, Haixin Liu, Wenting Li, Wei Hong
Summary: Nanoscale structures have been developed for various functions in cancer therapy, including diagnosis, biomedical visualization, tissue regeneration, and drug delivery. By using biocompatible chitosan oligosaccharides and gold nanorods, a drug delivery system was designed that effectively delivered drugs to tumor sites and selectively targeted cancer cells. The system also had drug release capability and magnetic resonance imaging functionality, showing promising outcomes for tumor diagnosis and treatment.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Tejaswini Appidi, P. S. Rajalakshmi, Shubham A. Chinchulkar, Arpan Pradhan, Hajira Begum, Veeresh Shetty, Rohit Srivastava, Prabhusankar Ganesan, Aravind Kumar Rengan
Summary: This study reports on the synthesis of a hybrid lipo-polymeric nanosystem and demonstrates its ability to encapsulate both hydrophilic and hydrophobic molecules, as well as its enhanced cellular uptake. The nanosystem, surface coated with gold, exhibits a photothermal effect, triggering the production of intracellular ROS, DNA damage, and apoptotic cell death. Additionally, the surface-enhanced fluorescence of the nanosystem enables its application in cancer cell and zebrafish embryo imaging, as well as effective photothermal therapy against breast cancer.
Article
Pharmacology & Pharmacy
Huan Zhang, Jinshun Xu, Binyang Gao, Hong Wang, Jianbo Huang, Jie Zhou, Rui Yang, Feng Yan, Yulan Peng
Summary: The study successfully improved the tumor microenvironment of breast cancer using a new synergistic cascade strategy involving mild hyperthermia and smart drug delivery system, resulting in enhanced drug delivery and therapeutic efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Materials Science, Biomaterials
Lu Tang, Qiaqia Xiao, Yue Yin, Yijun Mei, Jing Li, Lin Xu, Hongbin Gao, Wei Wang
Summary: This study successfully developed a novel nanoplatform based on a lipid-polymer hybrid system for targeted cancer treatment by co-loading photothermal and chemotherapeutic drugs. The nanoplatform demonstrated good stability, imaging properties, and significant inhibitory effect on tumor growth.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Medicinal
Sahar Eljack, Stephanie David, Igor Chourpa, Areeg Faggad, Emilie Allard-Vannier
Summary: In this work, lipid-based nanoparticles were developed to deliver the tyrosine kinase inhibitor Lapatinib and siRNA in an injectable form. The nanoparticles showed good cell uptake and exhibited cytotoxic effects.
Article
Chemistry, Multidisciplinary
Manxiang Wu, Tianxiang Chen, Lianfu Wang, Ozioma Udochukwu Akakuru, Xuehua Ma, Jinshan Xu, Jiapeng Hu, Jia Chen, Qianlan Fang, Aiguo Wu, Qiang Li
Summary: This study developed a core membrane nanoplatform for enhanced treatment of triple-negative breast cancer (TNBC) using biomimetic nanotechnology and tumor microenvironment (TME) responsiveness. The nanoplatform showed precise drug delivery and improved oxygen levels in the tumor, resulting in enhanced chemotherapy/phototherapy. In addition, it exhibited good fluorescence and magnetic resonance imaging performances, enabling image-guided combination tumor therapy.
Article
Materials Science, Biomaterials
Sajmina Khatun, Monika Pebam, Chandra Lekha Putta, Aravind Kumar Rengan
Summary: Protein-based nanoplatforms have emerged as an important domain in delivering anticancer therapeutics, addressing the heterogeneity of TNBC and the side effects of chemo drugs. In this study, 10-Hydroxycamptothecin was encapsulated in biocompatible casein by synthesizing nanoparticles, showing excellent biocompatibility and therapeutic efficacy for TNBC treatment.
BIOMATERIALS SCIENCE
(2023)