Multistage Nanovehicle Delivery System Based on Stepwise Size Reduction and Charge Reversal for Programmed Nuclear Targeting of Systemically Administered Anticancer Drugs

Efficient nuclear drug translocation and improved drug efficacy mediated by acidity-responsive boronate-linked dextran/cholesterol nanoassembly

(2015) Jing-Yi Zhu et al.   BIOMATERIALS

Ultrasmall Gold Nanoparticles as Carriers for Nucleus-Based Gene Therapy Due to Size-Dependent Nuclear Entry

(2014) Shuaidong Huo et al.   ACS Nano

MSN-Mediated Sequential Vascular-to-Cell Nuclear-Targeted Drug Delivery for Efficient Tumor Regression

(2014) Limin Pan et al.   ADVANCED MATERIALS

PEGylated liposomes with NGR ligand and heat-activable cell-penetrating peptide–doxorubicin conjugate for tumor-specific therapy

(2014) Yanfang Yang et al.   BIOMATERIALS

Tumor targeting by pH-sensitive, biodegradable, cross-linked N-(2-hydroxypropyl) methacrylamide copolymer micelles

(2014) Zhou Zhou et al.   BIOMATERIALS

Doxorubicin-loaded, charge reversible, folate modified HPMA copolymer conjugates for active cancer cell targeting

(2014) Lian Li et al.   BIOMATERIALS

The anti-tumor efficacy of curcumin when delivered by size/charge-changing multistage polymeric micelles based on amphiphilic poly(β-amino ester) derivates

(2014) Yang Yu et al.   BIOMATERIALS

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

(2014) Minghui Zan et al.   CHEMICAL COMMUNICATIONS

Passive versus Active Tumor Targeting Using RGD- and NGR-Modified Polymeric Nanomedicines

(2014) Sijumon Kunjachan et al.   NANO LETTERS

A Cell-Targeted, Size-Photocontrollable, Nuclear-Uptake Nanodrug Delivery System for Drug-Resistant Cancer Therapy

(2014) Liping Qiu et al.   NANO LETTERS

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

(2014) Sutapa Barua et al.   Nano Today

Dual endogenous stimuli-responsive polyplex micelles as smart two-step delivery nanocarriers for deep tumor tissue penetration and combating drug resistance of cisplatin

(2014) Junjie Li et al.   Journal of Materials Chemistry B

MSN Anti-Cancer Nanomedicines: Chemotherapy Enhancement, Overcoming of Drug Resistance, and Metastasis Inhibition

(2013) Qianjun He et al.   ADVANCED MATERIALS

Overcoming multidrug resistance of cancer cells by direct intranuclear drug delivery using TAT-conjugated mesoporous silica nanoparticles

(2013) Limin Pan et al.   BIOMATERIALS

Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer

(2013) Jisheng Xiao et al.   BIOMATERIALS

Size-Dependent Tumor Penetration and in Vivo Efficacy of Monodisperse Drug–Silica Nanoconjugates

(2013) Li Tang et al.   MOLECULAR PHARMACEUTICS

Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo

(2012) Keyang Huang et al.   ACS Nano

Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

(2012) You-Yong Yuan et al.   ADVANCED MATERIALS

The intranuclear release of a potential anticancer drug from small nanoparticles that are derived from intracellular dissociation of large nanoparticles

(2012) Yanbin Fan et al.   BIOMATERIALS

Simultaneous nuclear imaging and intranuclear drug delivery by nuclear-targeted multifunctional upconversion nanoprobes

(2012) Jia-nan Liu et al.   BIOMATERIALS

Challenges in design of translational nanocarriers

(2012) Qihang Sun et al.   JOURNAL OF CONTROLLED RELEASE

Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles

(2012) Limin Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery

(2012) Erlei Jin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cellular Uptake and Fate of PEGylated Gold Nanoparticles Is Dependent on Both Cell-Penetration Peptides and Particle Size

(2011) Eunkeu Oh et al.   ACS Nano

Luminescent Gold Nanoparticles with Efficient Renal Clearance

(2011) Chen Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intracellularly monitoring/imaging the release of doxorubicin from pH-responsive nanoparticles using Förster resonance energy transfer

(2011) Ko-Jie Chen et al.   BIOMATERIALS

Nuclear drug delivery for cancer chemotherapy

(2011) Meihua Sui et al.   JOURNAL OF CONTROLLED RELEASE

Biodegradable star HPMA polymer–drug conjugates: Biodegradability, distribution and anti-tumor efficacy

(2011) Tomáš Etrych et al.   JOURNAL OF CONTROLLED RELEASE

Tailor-Made Dual pH-Sensitive Polymer–Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery

(2011) Jin-Zhi Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

(2011) Jonathan W. Wojtkowiak et al.   MOLECULAR PHARMACEUTICS

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Multistage nanoparticle delivery system for deep penetration into tumor tissue

(2011) C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Doxorubicin as a Molecular Nanotheranostic Agent: Effect of Doxorubicin Encapsulation in Micelles or Nanoemulsions on the Ultrasound-Mediated Intracellular Delivery and Nuclear Trafficking

(2010) Praveena Mohan et al.   MOLECULAR PHARMACEUTICS

The Pharmacokinetics of Cell-Penetrating Peptides

(2010) Dikran Sarko et al.   MOLECULAR PHARMACEUTICS

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Cytotoxicity, intracellular distribution and uptake of doxorubicin and doxorubicin coupled to cell-penetrating peptides in different cell lines: A comparative study

(2009) Sonia Aroui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intracellular Trafficking and Subcellular Distribution of a Large Array of HPMA Copolymers

(2009) Jon Callahan et al.   BIOMACROMOLECULES

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

(2009) Steven D. Perrault et al.   NANO LETTERS

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting of Porous Hybrid Silica Nanoparticles to Cancer Cells

(2008) Jessica M. Rosenholm et al.   ACS Nano

Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting

(2008) Tomáš Etrych et al.   JOURNAL OF CONTROLLED RELEASE