4.4 Article

Highly Efficient Cycloaddition Reaction of 1,3-Diynes with Sodium Azide: A New Way to 5-Substituted-4-acetylene-1H-1,2,3-triazoles

Journal

JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 53, Issue 5, Pages 1367-1370

Publisher

WILEY
DOI: 10.1002/jhet.1950

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Funding

  1. NSFC [21272175]
  2. Pu Jiang program of Shanghai

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A cycloaddition reaction of a range of 1,3-diynes with sodium azide has been realized, which provided 5-substituted-4-acetylene-1H-1,2,3-triazoles in 75-99% yields. The chemical structures of the new compounds 3 are established by IR, NMR, Mass, and HRMS.

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