Review
Microbiology
Alejandro Tejada-Arranz, Hilde De Reuse
Summary: Helicobacter pylori is a Gram-negative bacterial pathogen that colonizes the stomach of about half of the human population worldwide, causing chronic gastritis and other serious diseases. It has evolved efficient adaptive strategies for gene expression control through transcriptional and post-transcriptional regulation.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ismael Riquelme, Pablo Perez-Moreno, Barbara Mora-Lagos, Carmen Ili, Priscilla Brebi, Juan Carlos Roa
Summary: Gastric cancer is a significant cause of cancer-related deaths, particularly among younger people. Late diagnosis, metastasis, and drug resistance contribute to the high mortality rate of gastric cancer. There is a need for new biomarkers and therapeutic targets. RNA-seq technology has identified long non-coding RNAs (lncRNAs) as potential regulators of cancer cells' signaling pathways, including the PI3K/AKT/mTOR pathway, and they may serve as diagnostic or prognostic biomarkers or therapeutic targets for gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Simona Cataldi, Mariagiovanna Tramontano, Valerio Costa, Marianna Aprile, Alfredo Ciccodicola
Summary: The increasing prevalence of diabetes mellitus worldwide leads to a higher incidence of macro- and micro-vascular complications, including diabetic retinopathy (DR), which is the leading cause of blindness in older diabetic patients. Chronic hyperglycemia is the main factor causing damage to retinal cells. Oxidative stress, inflammatory factors, and vascular endothelial growth factor signaling have been identified as contributors to the onset and progression of DR. Emerging evidence also suggests the involvement of non-coding RNA, particularly long non-coding RNAs (lncRNAs), in DR pathogenesis.
Article
Biochemistry & Molecular Biology
Christopher G. Fenton, Mithlesh Kumar Ray, Wei Meng, Ruth H. Paulssen
Summary: Long non-coding RNAs (lncRNAs) have been found to be involved in the development of ulcerative colitis (UC), and their interplay with DNA methylation and the role of environmental factors in disease development remain to be fully explored. This study analyzed mucosal biopsies from UC patients and normal controls to identify UC-associated lncRNAs regulated by differentially methylated regions (DMRs). The study also identified genes involved in inflammatory immune responses downstream of DMR-regulated lncRNAs. Understanding the interplay between lncRNA expression and DNA methylation in UC could enhance our knowledge of its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Giasemi C. Eptaminitaki, Nora Wolff, Dimitris Stellas, Konstantinos Sifakis, Stavroula Baritaki
Summary: Long non-coding RNAs (lncRNAs) play critical roles in cancer immunity, influencing tumorigenesis, malignant characteristics, and regulating cancer immune evasion and treatment response.
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Vinay Singh Tanwar, Marpadga A. Reddy, Rama Natarajan
Summary: Chronic metabolic disorders like obesity and diabetes are associated with accelerated vascular complications, and long non-coding RNAs play a crucial role in regulating gene expression in these diseases. Understanding the characteristics and mechanisms of lncRNAs can provide insights for the development of new therapeutic approaches to manage these disorders effectively.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chao Wang, Yiyang Hu, Huan Yang, Sumin Wang, Bo Zhou, Yulu Bao, Yu Huang, Qiang Luo, Chuan Yang, Xia Xie, Shiming Yang
Summary: Gastric cancer, a common malignant tumor of the digestive system, is influenced by genetic, environmental, and microbial factors. Infection of Helicobacter pylori is closely related to the occurrence of gastric cancer, while non-coding RNA plays a crucial role in tumor progression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Weihan Sun, Yijian Lu, Heng Zhang, Jun Zhang, Xinyu Fang, Jianxun Wang, Mengyang Li
Summary: Mitochondrial non-coding RNAs play important roles in regulating gene expression, protein import, and maintaining mitochondrial homeostasis.
Article
Neurosciences
Shraddha Tripathi, Bakhya Shree, Stuti Mohapatra, Swati, Anirban Basu, Vivek Sharma
Summary: Long non-coding RNAs (lncRNAs) have emerged as important regulators in biological processes, interacting with proteins, RNA, and DNA to regulate gene expression pathways. Altered lncRNA expression in CNS diseases contributes to regulating both pro-inflammatory and anti-inflammatory pathways. The review discusses molecular pathways, mechanisms, and therapeutic potential of lncRNAs in CNS disorders related to neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Medicine, Research & Experimental
Rong Dong, Bo Zhang, Biqin Tan, Nengming Lin
Summary: Macrophages play a crucial role in M2 polarization, which is regulated by various factors. Long non-coding RNAs (lncRNAs) are essential for the process, guiding macrophages towards an M2 phenotype through multiple mechanisms. Exosomal lncRNAs can also regulate polarization through paracrine action.
Review
Pharmacology & Pharmacy
Nirjhar Bhattacharyya, Vedansh Pandey, Malini Bhattacharyya, Abhijit Dey
Summary: Long non coding RNAs (lncRNAs) play crucial roles in neurological disorders, participating in pathogenesis through various mechanisms, and can serve as potential biomarkers and therapeutic targets.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ganesan Arunkumar
Summary: Long non-coding RNAs (lncRNAs) play significant roles in maintaining genomic integrity and regulating gene expression through interactions with chromatin-modifying complexes. They can function as building blocks to assemble different chromatin-modifying components and have been implicated in various diseases, potentially serving as diagnostic indicators and therapeutic targets.
BIOCHEMISTRY AND CELL BIOLOGY
(2023)
Review
Oncology
Jia Wu, Ying Zhu, Qingwei Cong, Qiumin Xu
Summary: Autophagy is a process that supports nutrient cycling and metabolic adaptation through lysosomal degradation. Recent studies have found that miRNAs and lncRNAs play important roles in the occurrence, invasion, development, and drug resistance of hepatocellular carcinoma (HCC) by regulating HCC cell autophagy. Understanding the specific miRNAs and lncRNAs involved and the related molecular mechanisms is crucial for HCC therapeutics.
Review
Medicine, Research & Experimental
Niladri Ganguly, Subrata Chakrabarti
Summary: Liver fibrosis is a major liver pathology worldwide, resulting from improper tissue repair following injury or inflammation. Long non-coding RNAs play a significant role in regulating gene expression and signaling in liver fibrosis. Potential therapeutic approaches targeting lncRNAs and related epigenetic processes are being considered as future treatment options for liver fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Engineering, Multidisciplinary
Chao Liu, Yongqiang Gong, Simon Laflamme, Brent Phares, Soumik Sarkar
MEASUREMENT SCIENCE AND TECHNOLOGY
(2017)
Article
Construction & Building Technology
Yongqiang Gong, Liang Cao, Simon Laflamme, Spencer Quiel, James Ricles, Douglas Taylor
STRUCTURAL CONTROL & HEALTH MONITORING
(2018)
Article
Engineering, Civil
Yongqiang Gong, Liang Cao, Simon Laflamme, James Ricles, Spencer Quiel, Douglas Taylor
ENGINEERING STRUCTURES
(2019)
Article
Engineering, Civil
Yongqiang Gong, Liang Cao, Simon Laflamme, James Ricles, Spencer Quiel, Douglas Taylor
ENGINEERING STRUCTURES
(2019)
Article
Acoustics
Yongqiang Gong, Liang Cao, Simon Laflamme, James Ricles, Spencer Quiel, Douglas Taylor
Summary: The study introduces a novel variable friction cladding connection capable of semi-actively mitigating multiple hazards, optimized through a dynamic design methodology. By using different design parameters to meet performance requirements under various hazards, the connection demonstrates significant vibration reduction performance.
JOURNAL OF VIBRATION AND CONTROL
(2021)
Article
Biotechnology & Applied Microbiology
Tailiang Lu, Chenglong Li, Cailing Xiang, Yongqiang Gong, Wei Peng, Chaowu Chen
Summary: CISD1 expression in hepatocellular carcinoma is positively associated with prognosis and immune infiltrating levels, making it a potential biomarker for prognosis assessment.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Cell Biology
Tailiang Lu, Chenglong Li, Cailing Xiang, Yongqiang Gong, Wei Peng, Futao Hou, Chaowu Chen
Summary: High expression of NFYB may be a promising prognostic biomarker for patients with gastric cancer, and it is associated with high T stage, high histological grade, diffuse gastric cancer, and early-onset GC, as well as CAFs infiltration.
Review
Oncology
Yong-Qiang Gong, Fu-Tao Hou, Cai-Ling Xiang, Cheng-Long Li, Guo-Huang Hu, Chao-Wu Chen
Summary: Melatonin plays a crucial role in GI cancer by modulating the GI tract, reducing cancer occurrence, and enhancing sensitivity to chemoradiotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Polymer Science
Yongqiang Gong, Tingting Gu, Tiantian Zhang, Songnan Li, Zhenyu Yu, Mingming Zheng, Yaqing Xiao, Yibin Zhou
Summary: This study investigated the effects of hydroxypropyl glutinous rice starch (HPGRS) and lactate-esterified glutinous rice starch (LAEGRS) on the dilute solution and gel properties of wheat starch (WS). HPGRS promoted chain extension, while LAEGRS led to hydrophobic association and inward curling of chains. Both HPGRS and LAEGRS formed attractive forces with WS and resulted in a uniform gel structure. HPGRS increased pasting viscosity, viscoelasticity, and springiness of WS gels, while reducing free water content and establishing tighter gel network structure. LAEGRS had opposite effects on WS gels.
Article
Acoustics
Liang Cao, Yongqiang Gong, Filippo Ubertini, Hao Wu, An Chen, Simon Laflamme
JOURNAL OF SOUND AND VIBRATION
(2020)
Proceedings Paper
Engineering, Electrical & Electronic
Yongqiang Gong, Liang Cao, Laura Micheli, Simon Laflamme, Spencer Quiel, James Ricles
ACTIVE AND PASSIVE SMART STRUCTURES AND INTEGRATED SYSTEMS XII
(2018)
Proceedings Paper
Optics
Laura Micheli, Liang Cao, Yongqiang Gong, Alessandro Cancelli, Simon Laflamme, Alice Alipour
ACTIVE AND PASSIVE SMART STRUCTURES AND INTEGRATED SYSTEMS 2017
(2017)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)