Computational modeling of the effect of five mutations on the structure of the ACE2 receptor and their correlation with infectivity and virulence of some emerged variants of SARS-CoV-2 suggests mechanisms of binding affinity dysregulation

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Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein

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(2020) Jun Lan et al.   NATURE

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Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

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ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population

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(2020) Hongjing Gu et al.   SCIENCE

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

(2020) Kui K. Chan et al.   SCIENCE

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Accurate prediction of stability changes in protein mutants by combining machine learning with structure based computational mutagenesis

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