Cell-type-specific population dynamics of diverse reward computations

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

(2022) Koichiro E. Kishi et al.   CELL

Neural mechanisms underlying the temporal organization of naturalistic animal behavior

(2022) Luca Mazzucato   eLife

Extracting the dynamics of behavior in sensory decision-making experiments

(2021) Nicholas A. Roy et al.   NEURON

Attractor dynamics gate cortical information flow during decision-making

(2021) Arseny Finkelstein et al.   NATURE NEUROSCIENCE

Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

(2021) Nicholas A. Steinmetz et al.   SCIENCE

Specialized neurons in the right habenula mediate response to aversive olfactory cues

(2021) Jung-Hwa Choi et al.   eLife

Accurate Localization of Linear Probe Electrode Arrays across Multiple Brains

(2021) Liu D. Liu et al.   eNeuro

All-Optical Electrophysiology Reveals the Role of Lateral Inhibition in Sensory Processing in Cortical Layer 1

(2020) Linlin Z. Fan et al.   CELL

Anatomical and single-cell transcriptional profiling of the murine habenular complex

(2020) Michael L Wallace et al.   eLife

Transcriptional and Spatial Resolution of Cell Types in the Mammalian Habenula

(2020) Yoshiko Hashikawa et al.   NEURON

Assigning transcriptomic class in the trigeminal ganglion using multiplex in situ hybridization and machine learning

(2020) Lars J. von Buchholtz et al.   PAIN

Computation Through Neural Population Dynamics

(2020) Saurabh Vyas et al.   Annual Review of Neuroscience

Multiple convergent hypothalamus–brainstem circuits drive defensive behavior

(2020) Matthew Lovett-Barron et al.   NATURE NEUROSCIENCE

Comprehensive Dual- and Triple-Feature Intersectional Single-Vector Delivery of Diverse Functional Payloads to Cells of Behaving Mammals

(2020) Lief E. Fenno et al.   NEURON

Deep posteromedial cortical rhythm in dissociation

(2020) Sam Vesuna et al.   NATURE

Deep brain optogenetics without intracranial surgery

(2020) Ritchie Chen et al.   NATURE BIOTECHNOLOGY

Exploring internal state-coding across the rodent brain

(2020) Scott M Sternson   CURRENT OPINION IN NEUROBIOLOGY

Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour

(2019) Joshua H. Jennings et al.   NATURE

Discrete attractor dynamics underlies persistent activity in the frontal cortex

(2019) Hidehiko K. Inagaki et al.   NATURE

A hypothalamus-habenula circuit controls aversion

(2019) Iakovos Lazaridis et al.   MOLECULAR PSYCHIATRY

Area-Specificity and Plasticity of History-Dependent Value Coding During Learning

(2019) Ryoma Hattori et al.   CELL

Neuronal Dynamics Regulating Brain and Behavioral State Transitions

(2019) Aaron S. Andalman et al.   CELL

Opposing effects of an atypical glycinergic and substance P transmission on interpeduncular nucleus plasticity

(2019) Riccardo Melani et al.   NEUROPSYCHOPHARMACOLOGY

Mu opioid receptors in the medial habenula contribute to naloxone aversion

(2019) L. J. Boulos et al.   NEUROPSYCHOPHARMACOLOGY

Controlling Visually Guided Behavior by Holographic Recalling of Cortical Ensembles

(2019) Luis Carrillo-Reid et al.   CELL

Bayesian Computation through Cortical Latent Dynamics

(2019) Hansem Sohn et al.   NEURON

Cortical layer–specific critical dynamics triggering perception

(2019) James H. Marshel et al.   SCIENCE

TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety‐related behaviors

(2019) Chang‐Hoon Cho et al.   EMBO REPORTS

Distributed coding of choice, action and engagement across the mouse brain

(2019) Nicholas A. Steinmetz et al.   NATURE

Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq

(2018) Shristi Pandey et al.   CURRENT BIOLOGY

Chrna5-expressing neurons in the interpeduncular nucleus mediate aversion primed by prior stimulation or nicotine exposure

(2018) Glenn Morton et al.   JOURNAL OF NEUROSCIENCE

Functional circuit architecture underlying parental behaviour

(2018) Johannes Kohl et al.   NATURE

Three-dimensional intact-tissue sequencing of single-cell transcriptional states

(2018) Xiao Wang et al.   SCIENCE

Inferring single-trial neural population dynamics using sequential auto-encoders

(2018) Chethan Pandarinath et al.   NATURE METHODS

DeepLabCut: markerless pose estimation of user-defined body parts with deep learning

(2018) Alexander Mathis et al.   NATURE NEUROSCIENCE

Transforming Sensory Cues into Aversive Emotion via Septal-Habenular Pathway

(2018) Guang-Wei Zhang et al.   NEURON

A Dynamical Systems Perspective on Flexible Motor Timing

(2018) Evan D. Remington et al.   TRENDS IN COGNITIVE SCIENCES

Latent Factors and Dynamics in Motor Cortex and Their Application to Brain–Machine Interfaces

(2018) Chethan Pandarinath et al.   JOURNAL OF NEUROSCIENCE

Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs

(2018) Erica Seigneur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens

(2018) David Ottenheimer et al.   Nature Communications

The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation

(2017) Ian McLaughlin et al.   JOURNAL OF NEUROCHEMISTRY

A circuit-based mechanism underlying familiarity signaling and the preference for novelty

(2017) Susanna Molas et al.   NATURE NEUROSCIENCE

Variational Latent Gaussian Process for Recovering Single-Trial Dynamics from Population Spike Trains

(2017) Yuan Zhao et al.   NEURAL COMPUTATION

Fronto-parietal Cortical Circuits Encode Accumulated Evidence with a Diversity of Timescales

(2017) Benjamin B. Scott et al.   NEURON

Retrograde inhibition by a specific subset of interpeduncular α5 nicotinic neurons regulates nicotine preference

(2017) Jessica L. Ables et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ring attractor dynamics in theDrosophilacentral brain

(2017) Sung Soo Kim et al.   SCIENCE

History-based action selection bias in posterior parietal cortex

(2017) Eun Jung Hwang et al.   Nature Communications

Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences

(2016) Li Ye et al.   CELL

Prefrontal Parvalbumin Neurons in Control of Attention

(2016) Hoseok Kim et al.   CELL

The habenula

(2016) Vijay Mohan K. Namboodiri et al.   CURRENT BIOLOGY

Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making

(2016) Kelly A. Zalocusky et al.   NATURE

History-dependent variability in population dynamics during evidence accumulation in cortex

(2016) Ari S Morcos et al.   NATURE NEUROSCIENCE

Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data

(2016) Eftychios A. Pnevmatikakis et al.   NEURON

Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors

(2016) Xueyan Pang et al.   NEUROPHARMACOLOGY

A dynamic code for economic object valuation in prefrontal cortex neurons

(2016) Ken-Ichiro Tsutsui et al.   Nature Communications

Hypothalamic CRH neurons orchestrate complex behaviours after stress

(2016) Tamás Füzesi et al.   Nature Communications

Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits

(2015) Talia N. Lerner et al.   CELL

Roles of the Lateral Habenula and Anterior Cingulate Cortex in Negative Outcome Monitoring and Behavioral Adjustment in Nonhuman Primates

(2015) Takashi Kawai et al.   NEURON

Diversity of Transgenic Mouse Models for Selective Targeting of Midbrain Dopamine Neurons

(2015) Stephan Lammel et al.   NEURON

Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal

(2015) Rubing Zhao-Shea et al.   Nature Communications

Transcriptomic-anatomic analysis of the mouse habenula uncovers a high molecular heterogeneity among neurons in the lateral complex, while gene expression in the medial complex largely obeys subnuclear boundaries

(2014) Franziska Wagner et al.   Brain Structure & Function

Efferent Pathways of the Mouse Lateral Habenula

(2014) Lely A. Quina et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Role of the Dorsal Medial Habenula in the Regulation of Voluntary Activity, Motor Function, Hedonic State, and Primary Reinforcement

(2014) Y.-W. A. Hsu et al.   JOURNAL OF NEUROSCIENCE

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

(2014) Michael J. Krashes et al.   NATURE

Targeting cells with single vectors using multiple-feature Boolean logic

(2014) Lief E Fenno et al.   NATURE METHODS

Cortical Control of Arm Movements: A Dynamical Systems Perspective

(2013) Krishna V. Shenoy et al.   Annual Review of Neuroscience

Medial Habenula Output Circuit Mediated by  5 Nicotinic Receptor-Expressing GABAergic Neurons in the Interpeduncular Nucleus

(2013) Y.-W. A. Hsu et al.   JOURNAL OF NEUROSCIENCE

Diverging neural pathways assemble a behavioural state from separable features in anxiety

(2013) Sung-Yon Kim et al.   NATURE

Distinct behavioural and network correlates of two interneuron types in prefrontal cortex

(2013) D. Kvitsiani et al.   NATURE

Context-dependent computation by recurrent dynamics in prefrontal cortex

(2013) Valerio Mante et al.   NATURE

A Unique Population of Ventral Tegmental Area Neurons Inhibits the Lateral Habenula to Promote Reward

(2013) Alice M. Stamatakis et al.   NEURON

Distinct Roles of Segregated Transmission of the Septo-Habenular Pathway in Anxiety and Fear

(2013) Takashi Yamaguchi et al.   NEURON

From fixed points to chaos: Three models of delayed discrimination

(2013) Omri Barak et al.   PROGRESS IN NEUROBIOLOGY

The medial habenula as a regulator of anxiety in adult zebrafish

(2013) Ajay S. Mathuru et al.   Frontiers in Neural Circuits

Genetic dissection of medial habenula–interpeduncular nucleus pathway function in mice

(2013) Yuki Kobayashi et al.   Frontiers in Behavioral Neuroscience

Molecular characterization of the subnuclei in rat habenula

(2012) Hidenori Aizawa et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation

(2012) Rohit Prakash et al.   NATURE METHODS

Opening the Black Box: Low-Dimensional Dynamics in High-Dimensional Recurrent Neural Networks

(2012) David Sussillo et al.   NEURAL COMPUTATION

Morphologic and immunohistochemical organization of the human habenular complex

(2011) Eugenia Díaz et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Quality Metrics to Accompany Spike Sorting of Extracellular Signals

(2011) D. N. Hill et al.   JOURNAL OF NEUROSCIENCE

Negative Reward Signals from the Lateral Habenula to Dopamine Neurons Are Mediated by Rostromedial Tegmental Nucleus in Primates

(2011) S. Hong et al.   JOURNAL OF NEUROSCIENCE

Spatial gradients and multidimensional dynamics in a neural integrator circuit

(2011) Andrew Miri et al.   NATURE NEUROSCIENCE

Lateral habenula neurons signal errors in the prediction of reward information

(2011) Ethan S Bromberg-Martin et al.   NATURE NEUROSCIENCE

Aversion to Nicotine Is Regulated by the Balanced Activity of β4 and α5 Nicotinic Receptor Subunits in the Medial Habenula

(2011) Silke Frahm et al.   NEURON

Single-Trial Neural Correlates of Arm Movement Preparation

(2011) Afsheen Afshar et al.   NEURON

Measuring impulsivity in mice: the five-choice serial reaction time task

(2011) Sandra Sanchez-Roige et al.   PSYCHOPHARMACOLOGY

The habenula: from stress evasion to value-based decision-making

(2010) Okihide Hikosaka   NATURE REVIEWS NEUROSCIENCE

Distinct Roles of Rodent Orbitofrontal and Medial Prefrontal Cortex in Decision Making

(2010) Jung Hoon Sul et al.   NEURON

Multiple Timescales of Memory in Lateral Habenula and Dopamine Neurons

(2010) Ethan S. Bromberg-Martin et al.   NEURON

Cortical Preparatory Activity: Representation of Movement or First Cog in a Dynamical Machine?

(2010) Mark M. Churchland et al.   NEURON

The multiple pathways for itch and their interactions with pain

(2010) Steve Davidson et al.   TRENDS IN NEUROSCIENCES

elastix: A Toolbox for Intensity-Based Medical Image Registration

(2009) S. Klein et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Gaussian-Process Factor Analysis for Low-Dimensional Single-Trial Analysis of Neural Population Activity

(2009) Byron M. Yu et al.   JOURNAL OF NEUROPHYSIOLOGY

Neurochemical phenotypes of the afferent and efferent projections of the mouse medial habenula

(2009) C. Qin et al.   NEUROSCIENCE

The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats

(2008) Andrea Bari et al.   Nature Protocols

The Globus Pallidus Sends Reward-Related Signals to the Lateral Habenula

(2008) Simon Hong et al.   NEURON

Electrolytic lesions of the habenula attenuate brain stimulation reward

(2007) Marie-Claude Morissette et al.   BEHAVIOURAL BRAIN RESEARCH