Absorption, metabolism and excretion of [14C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate

Absorption, Distribution, Metabolism and Excretion of [14C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism

(2022) Upendra P. Dahal et al.   DRUG METABOLISM AND DISPOSITION

Nonclinical Safety Profile of Sotorasib, a KRASG12C-Specific Covalent Inhibitor for the Treatment of KRAS p.G12C-Mutated Cancer

(2021) Katsu Ishida et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Characterization of covalent binding of tyrosine kinase inhibitors to plasma proteins

(2020) Xiaoyun Liu et al.   Drug Metabolism and Pharmacokinetics

Photobinding of Triflusal to Human Serum Albumin Investigated by Fluorescence, Proteomic Analysis, and Computational Studies

(2019) Oscar Molins-Molina et al.   Frontiers in Pharmacology

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

(2019) Jude Canon et al.   NATURE

Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

(2019) Brian A. Lanman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of cAMS for 14C microtracer ADME studies: opportunities to change the current drug development paradigm

(2018) Frédéric Lozac'h et al.   Bioanalysis

Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future

(2016) Gabriele Sabbioni et al.   CHEMICAL RESEARCH IN TOXICOLOGY

An evaluation of human ADME and mass balance studies using regular or low doses of radiocarbon

(2016) A.F. Roffel et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers

(2011) Peter Stopfer et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Evaluation of CYP2C8 Inhibition In Vitro: Utility of Montelukast as a Selective CYP2C8 Probe Substrate

(2011) B. M. VandenBrink et al.   DRUG METABOLISM AND DISPOSITION

Selection of Alternative CYP3A4 Probe Substrates for Clinical Drug Interaction Studies Using In Vitro Data and In Vivo Simulation

(2010) R. S. Foti et al.   DRUG METABOLISM AND DISPOSITION

Human radiolabeled mass balance studies: objectives, utilities and limitations

(2009) Natalia Penner et al.   BIOPHARMACEUTICS & DRUG DISPOSITION