Journal
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
Volume 23, Issue 6, Pages 324-332Publisher
WILEY
DOI: 10.1002/jhbp.343
Keywords
Colorectal neoplasms; Liver neoplasms; Neoplasm metastasis; Stomach neoplasms; Survival analysis
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BackgroundThe aim of this retrospective study was to clarify the difference in behavior and outcome after initial hepatectomy between gastric cancer liver metastases (GCLM) and colorectal cancer liver metastases (CCLM). MethodsData for patients undergoing curative hepatectomy for liver-only metastases from colorectal cancer (n=193) and gastric cancer (n=26) performed at single institution with the same criteria regarding the status of liver metastases were reviewed. Post-hepatectomy recurrence pattern, re-resection for recurrence, and three different endpoints were evaluated. ResultsThere was no significant difference between the GCLM and the CCLM in the incidence of recurrence (69% vs. 63%, P=0.553) and recurrence-free survival (median, 15.2months vs. 16.5months, P=0.230) following initial hepatectomy for liver metastases. However, the GCLM had a higher frequency of systemic unresectable recurrences than the CCLM. Time to surgical failure (median, 15.2months vs. 39.7months, P=0.006) and overall survival (median, 20.1months vs. 66.2months, P<0.001) were significantly shorter in the GCLM than in the CCLM. ConclusionsGCLM shows more systemic and aggressive oncological behavior than CCLM after curative hepatectomy even when metastases are confined only to the liver at the time of initial hepatectomy.
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