Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion

Calreticulin variant stratified driver mutational status and prognosis in essential thrombocythemia

(2016) Yoseph C. Elala et al.   AMERICAN JOURNAL OF HEMATOLOGY

Mutant calreticulin-expressing cells induce monocyte hyperreactivity through a paracrine mechanism

(2016) Michael R. Garbati et al.   AMERICAN JOURNAL OF HEMATOLOGY

Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms

(2016) M. Araki et al.   BLOOD

Thrombopoietin receptor is required for the oncogenic function of CALR mutants

(2016) H Nivarthi et al.   LEUKEMIA

Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation

(2016) S. Elf et al.   Cancer Discovery

Polycythemia vera and essential thrombocythemia: 2015 update on diagnosis, risk-stratification and management

(2015) Ayalew Tefferi et al.   AMERICAN JOURNAL OF HEMATOLOGY

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants

(2015) I. Chachoua et al.   BLOOD

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

(2015) C. Marty et al.   BLOOD

The non-peptide thrombopoietin receptor agonist eltrombopag stimulates megakaryopoiesis in bone marrow cells from patients with relapsed multiple myeloma

(2015) Jee-Yeong Jeong et al.   Journal of Hematology & Oncology

Rare FLT3 deletion mutants may provide additional treatment options to patients with AML: an approach to individualized medicine

(2015) N Chatain et al.   LEUKEMIA

Differential clinical effects of different mutation subtypes in CALR-mutant myeloproliferative neoplasms

(2015) D Pietra et al.   LEUKEMIA

Validation of the differential prognostic impact of type 1/type 1-like versus type 2/type 2-like CALR mutations in myelofibrosis

(2015) P Guglielmelli et al.   Blood Cancer Journal

Presence of calreticulin mutations in JAK2-negative polycythemia vera

(2014) J. Broseus et al.   BLOOD

Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value

(2014) A M Vannucchi et al.   LEUKEMIA

PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway

(2013) A. Kauskot et al.   BLOOD

Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

(2013) J. Nangalia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

(2013) Thorsten Klampfl et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Calreticulin in the immune system: ins and outs

(2012) Malini Raghavan et al.   TRENDS IN IMMUNOLOGY

Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease

(2011) C. Elling et al.   BLOOD

The pathogenesis of essential thrombocythemia

(2011) Philip A. Beer   CURRENT OPINION IN HEMATOLOGY

PTEN regulates collagen-induced platelet activation

(2010) Z. Weng et al.   BLOOD

Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum

(2009) Marek Michalak et al.   BIOCHEMICAL JOURNAL

Calreticulin: non-endoplasmic reticulum functions in physiology and disease

(2009) Leslie I. Gold et al.   FASEB JOURNAL

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

(2009) Chunaram Choudhary et al.   MOLECULAR CELL

Is there an alternative to the proteasome in cytosolic protein degradation?

(2008) Luis C. Antón et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

NF-E2-mediated enhancement of megakaryocytic differentiation and platelet production in vitro and in vivo

(2007) Ee-ling Fock et al.   EXPERIMENTAL HEMATOLOGY