Article
Cardiac & Cardiovascular Systems
Kangjoon Kim, Ah Young Leem, Song Yee Kim, Kyung Soo Chung, Moo Suk Park, Young Sam Kim, Jin Gu Lee, Hyo Chae Paik, Su Hwan Lee
Summary: This study investigated the incidence of complications related to ECMO support as a bridge to lung transplantation (BTT) and their association with patient outcomes. The results showed that complications during ECMO support were associated with unfavorable outcomes in lung transplantation.
Article
Critical Care Medicine
Darryl Abrams, Cara Agerstrand, Jeremy R. Beitler, Christian Karagiannidis, Purnema Madahar, Natalie H. Yip, Antonio Pesenti, Arthur S. Slutsky, Laurent Brochard, Daniel Brodie
Summary: Ultra-lung-protective ventilation is a strategy that aims to achieve lower airway pressures and tidal volumes. Some patients may benefit from this strategy, but its application is limited by respiratory acidosis and associated hematological complications. Only in very severe cases of acute respiratory distress syndrome, using extracorporeal membrane oxygenation to accomplish ultra-lung-protective ventilation may have a favorable risk-to-benefit profile.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Samantha E. Halpern, Mary C. Wright, Gabrielle Madsen, Bryan Chow, Chelsea S. Harris, John C. Haney, Jacob A. Klapper, Brandi A. Bottiger, Matthew G. Hartwig
Summary: This study compared the impact of planned venoarterial extracorporeal membrane oxygenation (VA ECMO) and off-pump support on the textbook outcome in bilateral orthotopic lung transplantation (BOLT) patients without pulmonary hypertension. The results demonstrated that planned VA ECMO was associated with a higher likelihood of achieving textbook outcome compared to planned off-pump support.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Holger Thiele, Uwe Zeymer, Ibrahim Akin, Michael Behnes, Tienush Rassaf, Amir Abbas Mahabadi, Ralf Lehmann, Ingo Eitel, Tobias Graf, Tim Seidler, Andreas Schuster, Carsten Skurk, Daniel Duerschmied, Peter Clemmensen, Marcus Hennersdorf, Stephan Fichtlscherer, Ingo Voigt, Melchior Seyfarth, Stefan John, Sebastian Ewen, Axel Linke, Eike Tigges, Peter Nordbeck, Leonhard Bruch, Christian Jung, Jutta Franz, Philipp Lauten, Tomaz Goslar, Hans-Josef Feistritzer, Janine Poess, Eva Kirchhof, Taoufik Ouarrak, Steffen Schneider, Steffen Desch, Anne Freund, ECLS-SHOCK Investigators
Summary: In patients with acute myocardial infarction complicated by cardiogenic shock, early extracorporeal life support (ECLS) combined with standard medical treatment did not reduce mortality.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Shao-Hui Guo, Ang Li, Peng-Fei Yin, Sheng-Mei Zhu, Yong-Xing Yao
Summary: This case study demonstrated the successful lung transplantation in a patient with irreversible lung damage caused by COVID-19 pneumonia. Despite challenges such as age and comorbidities, lung transplantation remains a potential therapy for critical COVID-19 patients.
Article
Cardiac & Cardiovascular Systems
Taylor Nordan, Andre C. Critsinelis, Shant H. Mahrokhian, Navin K. Kapur, Katherine L. Thayer, Frederick Y. Chen, Gregory S. Couper, Masashi Kawabori
Summary: The new donor heart allocation system has a positive impact on patients undergoing heart transplantation with extracorporeal membrane oxygenation, leading to shorter waitlist times, reduced preoperative comorbidities, and improved 180-day survival rates compared to the old system.
CIRCULATION-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Jawad Salman, Beeke-Alina Bernhard, Fabio Ius, Reza Poyanmehr, Wiebke Sommer, Khalil Aburahma, Hani Alhadidi, Thierry Siemeni, Christian Kuehn, Murat Avsar, Axel Haverich, Gregor Warnecke, Igor Tudorache
Summary: This study aimed to identify risk factors for the need of intra-operative ECMO use in lung transplant patients with pulmonary fibrosis. Factors such as preoperative proof of pulmonary hypertension, mean pulmonary arterial pressure, and pulmonary vascular resistance were identified as risk factors, while increased recipient body surface area and higher cardiac output were protective factors. The post-operative course was found to be more complicated in the ECMO+ group, although long-term survival did not differ significantly among groups.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Yanfeng Zhao, Yiliang Su, Ruowang Duan, Jiong Song, Xiaogang Liu, Lei Shen, Junrong Ding, Pei Zhang, Minwei Bao, Chang Chen, Yuming Zhu, Gening Jiang, Yuping Li
Summary: This study reviewed the clinical outcomes of lung transplantation patients who received ECMO support in a single center in China. The study found that prophylactic intraoperative ECMO and post-operative ECMO prolongation showed promising survival outcomes and acceptable complication rates in lung transplantation patients.
FRONTIERS IN MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Ahad Syed, Sarah Kerdi, Adnan Qamar
Summary: Artificial lung technology is advancing rapidly, offering hope for patients in need of respiratory support. From rehabilitation to transplantation, the search for safe and effective artificial lungs is critical. This review details the key advances in the historical development of artificial lungs, outlining the current state of extracorporeal membrane oxygenation, intravascular lung assists, and other technologies.
BIOENGINEERING-BASEL
(2021)
Review
Anesthesiology
V Zochios, D. Brodie, K. Shekar, M. J. Schultz, K. K. S. Parhar
Summary: Veno-venous extracorporeal membrane oxygenation (ECMO) is used for patients with acute respiratory distress syndrome (ARDS) who have severely impaired gas exchange despite standard lung-protective ventilation. ECMO allows for ultra-lung-protective ventilation by directly removing carbon dioxide. However, the use of sedation and neuromuscular blocking drugs may impact long-term outcomes and there is a lack of large-scale prospective data on optimal invasive ventilation practices.
Review
Respiratory System
Eleonora Faccioli, Ilhan Inci
Summary: By analyzing 14 published papers in the last seven years, this review provides an updated overview of the peri and post-operative outcomes of patients bridged to lung transplantation (LTx) with extracorporeal life support (ECLS). It concludes that ECLS can be a good strategy for critically ill patients to remain eligible for LTx with satisfying post-operative outcomes in highly experienced centers.
JOURNAL OF THORACIC DISEASE
(2023)
Review
Critical Care Medicine
Alexandra Schou, Jesper Molgaard, Lars Willy Andersen, Soren Holm, Marc Sorensen
Summary: The past 50 years of extracorporeal life support (ECLS) has had a significant impact on modern medicine, presenting various ethical challenges. This study identified three main ethical discourses related to ECLS: trials and evidence of ECLS usage, ECLS allocation and decision-making, and death on ECLS and ECLS in organ donation. The findings highlight the importance of a shared decision-making approach at the limits of medical care.
Article
Multidisciplinary Sciences
Rene Rissel, Sascha Koelm, Markus Schepers, Daniel-Sebastian Dohle, Joerg Albers, Mehmet Oezkur, Marc Kriege, Marc Bodenstein
Summary: This study aimed to explore the correlation between lactate peak concentration and clearance in the blood, and mortality during extracorporeal life support (ECLS) therapy. The results showed that higher lactate peak levels and poor lactate clearance were associated with increased mortality during ECLS therapy. Additionally, deceased patients had higher SAPSII scores, received more transfusions, and had higher rates of epinephrine usage.
Article
Engineering, Biomedical
Vittorio Scaravilli, Jacopo Fumagalli, Lorenzo Rosso, Federico Polli, Mauro Panigada, Chiara Abbruzzese, Stefania Crotti, Alfredo Lissoni, Mario Nosotti, Antonio Pesenti, Alberto Zanella, Giacomo Grasselli
Summary: The use of a novel no-heparin management approach during ECMO bridging to lung transplantation (LuTX) can effectively reduce the risk of perioperative bleeding, even in high-risk patients. Prospective studies are needed to further validate the effectiveness of this strategy.
Article
Medicine, General & Internal
Ryan P. Barbaro, Graeme MacLaren, Philip S. Boonstra, Alain Combes, Cara Agerstrand, Gail Annich, Rodrigo Diaz, Eddy Fan, Katarzyna Hryniewicz, Roberto Lorusso, Matthew L. Paden, Christine M. Stead, Justyna Swol, Theodore J. Iwashyna, Arthur S. Slutsky, Daniel Brodie
Summary: The study examined the use of ECMO for COVID-19 patients during 2020 globally, showing lower in-hospital mortality rates in early-adopting ECMO centres and higher rates in late-adopting centres.
Article
Cardiac & Cardiovascular Systems
Marius M. Hoeper, Christine Pausch, Karen M. Olsson, Doerte Huscher, David Pittrow, Ekkehard Gruenig, Gerd Staehler, Carmine Dario Vizza, Henning Gall, Oliver Distler, Christian Opitz, J. Simon R. Gibbs, Marion Delcroix, H. Ardeschir Ghofrani, Ralf Ewert, Harald Kaemmerer, Hans-Joachim Kabitz, Dirk Skowasch, Juergen Behr, Katrin Milger, Michael Halank, Heinrike Wilkens, Hans-Juergen Seyfarth, Matthias Held, Daniel Dumitrescu, Iraklis Tsangaris, Anton Vonk-Noordegraaf, Silvia Ulrich, Hans Klose, Martin Claussen, Stephan Eisenmann, Kai-Helge Schmidt, Stephan Rosenkranz, Tobias J. Lange
Summary: In this study, the prognostic value of improvement endpoints in patients with pulmonary arterial hypertension was evaluated. It was found that improvements in functional class were associated with improved survival, while improvements in 6-min walking distance and NT-proBNP had minimal predictive value. Improvements in multicomponent endpoints and risk stratification tools were also associated with improved survival.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Respiratory System
Marc Humbert, Gabor Kovacs, Marius M. Hoeper, Roberto Badagliacca, Rolf M. F. Berger, Margarita Brida, Jorn Carlsen, Andrew J. S. Coats, Pilar Escribano-Subias, Pisana Ferrari, Diogenes S. Ferreira, Hossein Ardeschir Ghofrani, George Giannakoulas, David G. Kiely, Eckhard Mayer, Gergely Meszaros, Blin Nagavci, Karen M. Olsson, Joanna Pepke-Zaba, Jennifer K. Quint, Goran Radegran, Gerald Simonneau, Olivier Sitbon, Thomy Tonia, Mark Toshner, Jean Luc Vachiery, Anton Vonk Noordegraaf, Marion Delcroix, Stephan Rosenkranz
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Marc Humbert, Vallerie McLaughlin, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Marius M. Hoeper, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Hossein-Ardeschir Ghofrani, Pilar Escribano Subias, Jeremy Feldman, Gisela Meyer, David Montani, Karen M. Olsson, Solaiappan Manimaran, Janethe de Oliveira Pena, David B. Badesch
Summary: In participants with pulmonary arterial hypertension, 24 weeks of sotatercept resulted in a significant reduction in pulmonary vascular resistance. This study reports the longer-term safety and efficacy of sotatercept in the PULSAR open-label extension, showing that sotatercept has good safety and efficacy in patients with pulmonary arterial hypertension.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Stephan Rosenkranz, Christine Pausch, John G. Coghlan, Doerte Huscher, David Pittrow, Ekkehard Gruenig, Gerd Staehler, Carmine Dario Vizza, Henning Gall, Oliver Distler, Marion Delcroix, Hossain A. Ghofrani, Ralf Ewert, Han -Joachim Kabitz, Dirk Skowasch, Juergen Behr, Katrin Milger, Michael Halank, Heinrike Wilkens, Hans-Juergen Seyfarth, Matthias Held, Laura Scelsi, Claus Neurohr, Anton Vonk-Noordegraaf, Silvia Ulrich, Hans Klose, Martin Claussen, Stephan Eisenmann, Kai-Helge Schmidt, Bjoern Andrew Remppis, Andris Skride, Elena Jureviciene, Lina Gumbiene, Skaidrius Miliauskas, Judith Loeffler-Ragg, Tobias J. Lange, Karen M. Olsson, Marius M. Hoeper, Christian Opitz
Summary: This study analyzed the response to PAH therapy in IPAH patients and compared the differences between patients without comorbidities, those with 1-2 comorbidities, and those with 3-4 comorbidities. The results showed that patients with comorbidities had smaller improvements in functional class, 6-minute walking distance, BNP/NT-pro-BNP, and mortality risk compared to patients without comorbidities. However, the 4-strata risk tool predicted the outcome in IPAH patients regardless of the presence of comorbidities.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Biophysics
Catherina Lueck, Asterios Tzalavras, Philipp Wohlfarth, Elisabeth Meedt, Michael Kiehl, Amin T. Turki, Marius M. Hoeper, Matthias Eder, Julia Cserna, Nina Buchtele, Daniel Wolff, Peter Schellongowski, Gernot Beutel, Tobias Liebregts
Summary: Chronic graft-vs-host disease has a major impact on non-relapse mortality, but data on ICU outcomes are lacking. The study found that severe liver, intestinal, or pulmonary cGvHD is associated with worse outcomes.
BONE MARROW TRANSPLANTATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Stephan Rosenkranz, Marion Delcroix, George Giannakoulas, Marius M. Hoeper, Gabor Kovacs, Marc Humbert
EUROPEAN HEART JOURNAL
(2023)
Article
Respiratory System
J. Gerry Coghlan, Sean Gaine, Richard Channick, Kelly M. Chin, Camille du Roure, J. Simon R. Gibbs, Marius M. Hoeper, Irene M. Lang, Stephen C. Mathai, Vallerie V. McLaughlin, Lada Mitchell, Gerald Simonneau, Olivier Sitbon, Victor F. Tapson, Nazzareno Galie
Summary: Further understanding of when to initiate therapies in pulmonary arterial hypertension (PAH) is important to improve long-term outcomes. Post hoc analyses of GRIPHON (NCT01106014) and exploratory analyses of TRITON (NCT02558231) suggested benefit of early selexipag initiation on long-term outcomes, despite no additional benefit versus initial double combination on haemodynamic and functional parameters in TRITON. These post hoc, pooled analyses build on previous insights, further supporting selexipag use within 6 months of diagnosis, including as part of triple therapy, to delay disease progression.
Article
Respiratory System
Hunter Gillies, Ralph Niven, Benjamin T. Dake, Murali M. Chakinala, Jeremy P. Feldman, Nicholas S. Hill, Marius M. Hoeper, Marc Humbert, Vallerie V. McLaughlin, Martin Kankam
Summary: AV-101, a dry powder inhaled formulation of imatinib, was well tolerated in healthy adults and significantly reduced the systemic exposure of imatinib compared with oral imatinib. An ongoing study will evaluate the safety, tolerability, and clinical benefit of AV-101 for pulmonary arterial hypertension.
Article
Medicine, General & Internal
Marius M. Hoeper, David B. Badesch, H. Ardeschir Ghofrani, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Vallerie V. McLaughlin, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Ekkehard Gruenig, Grzegorz Kopec, Gisela Meyer, Karen M. Olsson, Stephan Rosenkranz, Yayun Xu, Barry Miller, Marcie Fowler, John Butler, Joerg Koglin, Janethe de Oliveira Pena, Marc Humbert
Summary: This study confirms that in patients with stable background therapy, sotatercept can significantly improve the exercise capacity of patients with pulmonary arterial hypertension compared to placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Respiratory System
Gerald Simonneau, Elie Fadel, Anton Vonk Noordegraaf, Mark Toshner, Irene M. Lang, Frederikus A. Klok, Micheal C. McInnis, Nicholas Screaton, Michael M. Madani, Guillermo Martinez, Kiran Salaunkey, David P. Jenkins, Hiromi Matsubara, Philippe Brenot, Marius M. Hoeper, Hossein A. Ghofrani, Xavier Jais, Christoph B. Wiedenroth, Stefan Guth, Nick H. Kim, Joanna Pepke-Zaba, Marion Delcroix, Eckhard Mayer
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute pulmonary embolism caused by persistent obstruction of the pulmonary arteries. It requires timely and accurate diagnosis through imaging and haemodynamic assessment. Optimal therapy should be determined by an experienced multidisciplinary CTEPH team. This report summarizes current knowledge and key messages from the International CTEPH Conference, covering various aspects of the disease.
EUROPEAN RESPIRATORY REVIEW
(2023)
Letter
Cardiac & Cardiovascular Systems
Mardi Gomberg-Maitland, Vallerie V. Mclaughlin, David B. Badesch, Hossein-Ardeschir Ghofrani, Marius M. Hoeper, Marc Humbert, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Janethe de Oliveira Pena, Jonathan T. Lu, Solaiappan Manimaran, J. Simon R. Gibbs
JACC-HEART FAILURE
(2023)
Correction
Cardiac & Cardiovascular Systems
[Anonymous]
EUROPEAN HEART JOURNAL
(2023)
Meeting Abstract
Respiratory System
J. Fuge, D. Park, T. Von Lengerke, M. Richter, H. Gall, H. A. Ghofrani, J. C. Kamp, M. M. Hoeper, K. M. Olsson
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Respiratory System
D. Park, T. Meltendorf, K. G. Kahl, J. C. Kamp, M. J. Richter, H. Gall, H. A. Ghofrani, M. M. Hoeper, K. M. Olsson, J. Fuge
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Greer, C. Mueller, R. Vagi, R. Wolf-Maras, M. Klintschar, B. Jaeger, N. Schwerk, T. Fuehner, J. Salman, M. Hoeper, A. Haverich, F. Ius
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
