AR study of 1,2-benzisothiazole dioxide compounds that agonize HIF-2 stabilization and EPO production

Development of luspatercept to treat ineffective erythropoiesis

(2021) Anne Sophie Kubasch et al.   Blood Advances

Discovery of a Potent and Orally Bioavailable Hypoxia-Inducible Factor 2α (HIF-2α) Agonist and Its Synergistic Therapy with Prolyl Hydroxylase Inhibitors for the Treatment of Renal Anemia

(2021) Yancheng Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyridinyl Amide Ion Pairs as Lewis Base Organocatalysts

(2020) Julian Helberg et al.   JOURNAL OF ORGANIC CHEMISTRY

Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

(2020) Yongfu Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insight into the binding mode of HIF-2 agonists through molecular dynamic simulations and biological validation

(2020) Yancheng Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmacologic Targeting of Hypoxia-Inducible Factors

(2019) Gregg L. Semenza   Annual Review of Pharmacology and Toxicology

Bidirectional modulation of HIF-2 activity through chemical ligands

(2019) Dalei Wu et al.   Nature Chemical Biology

Switching the statistical C1:C3-ratio in threefold aromatic substitution of tribenzotriquinacenes towards the C3-isomer

(2018) Michael Mastalerz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The role of hypoxia-inducible factor-2 alpha in angiogenesis

(2018) Christina Befani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Antifungal Benzo[b]thiophene 1,1-dioxide IMPDH Inhibitors Exhibit Pan-Assay Interference (PAINS) Profiles

(2018) Lalith K. Kummari et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Kidney injury is independent of endothelial HIF-1α

(2015) Joanna Kalucka et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes

(2015) Yutaka Tojo et al.   MOLECULAR AND CELLULAR BIOLOGY

Anaemia in kidney disease: harnessing hypoxia responses for therapy

(2015) Mark J. Koury et al.   Nature Reviews Nephrology

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury

(2014) Pinelopi P. Kapitsinou et al.   JOURNAL OF CLINICAL INVESTIGATION

9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds

(2013) Francesco Calogero et al.   ChemPlusChem

Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

(2012) Qingdu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION