Specific disruption of glutathione-defense system with activatable single molecule-assembled nanoprodrug for boosted photodynamic/chemotherapy eradication of drug-resistant tumors

Harnessing GLUT1 Targeted Pro‐oxidant Ascorbate for Synergistic Phototherapeutics

(2022) Seyoung Koo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy

(2021) Xiaotong Cheng et al.   ACS Nano

Versatile gadolinium(III)-phthalocyaninate photoagent for MR/PA imaging-guided parallel photocavitation and photodynamic oxidation at single-laser irradiation

(2021) Ruijing Zhang et al.   BIOMATERIALS

Small‐Molecule Prodrug Nanoassemblies: An Emerging Nanoplatform for Anticancer Drug Delivery

(2021) Guanting Li et al.   Small

HOCl‐Activated Aggregation of Gold Nanoparticles for Multimodality Therapy of Tumors

(2021) Dongya Liu et al.   Advanced Science

Platinum Crosslinked Carbon Dot@TiO 2− x p‐n Junctions for Relapse‐Free Sonodynamic Tumor Eradication via High‐Yield ROS and GSH Depletion

(2021) Bijiang Geng et al.   Small

A Potent Strategy of Combinational Blow Toward Enhanced Cancer Chemo‐Photodynamic Therapy via Sustainable GSH Elimination

(2021) Jie Yu et al.   Small

Self-Delivered and Self-Monitored Chemo-Photodynamic Nanoparticles with Light-Triggered Synergistic Antitumor Therapies by Downregulation of HIF-1α and Depletion of GSH

(2020) Zhongtao Zhang et al.   ACS Applied Materials & Interfaces

Aptamer-Functionalized Upconverting Nanoformulations for Light-Switching Cancer-Specific Recognition and In Situ Photodynamic–Chemo Sequential Theranostics

(2020) Xudong Jin et al.   ACS Applied Materials & Interfaces

Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy

(2020) Jimei Zhang et al.   ACS Nano

Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging

(2020) Yuanyuan Yang et al.   ACS Nano

Photoactivated Nanosheets Accelerate Nucleus Access of Cisplatin for Drug‐Resistant Cancer Therapy

(2020) Fang Gao et al.   ADVANCED FUNCTIONAL MATERIALS

Bismuth‐Based Mesoporous Nanoball Carrying Sorafenib for Computed Tomography Imaging and Synergetic Chemoradiotherapy of Hepatocellular Carcinoma

(2020) Guang‐Cong Zhang et al.   Advanced Healthcare Materials

Single Small Molecule‐Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo

(2020) Kai Lin et al.   ADVANCED FUNCTIONAL MATERIALS

Thiol “Click” Chromene Ring Opening and Subsequent Cascade Nucleophilic Cyclization NIR Fluorescence Imaging Reveal High Levels of Thiol in Drug-Resistant Cells

(2020) Kaiqing Ma et al.   ANALYTICAL CHEMISTRY

A glutathione-activatable nanoplatform for enhanced photodynamic therapy with simultaneous hypoxia relief and glutathione depletion

(2020) Furong Liu et al.   CHEMICAL ENGINEERING JOURNAL

Synchronous detection of glutathione/hydrogen peroxide for monitoring redox status in vivo with a ratiometric upconverting nanoprobe

(2019) Judun Zheng et al.   Nano Research

A Mn(III)-Sealed Metal-Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics

(2019) Shuang-Shuang Wan et al.   ACS Nano

Self-facilitated ROS-responsive nanoassembly of heterotypic dimer for synergistic chemo-photodynamic therapy

(2019) Cong Luo et al.   JOURNAL OF CONTROLLED RELEASE

H2O2-responsive biodegradable nanomedicine for cancer-selective dual-modal imaging guided precise photodynamic therapy

(2019) Qin Zeng et al.   BIOMATERIALS

pH-responsive and self-targeting assembly from hyaluronic acid-based conjugate toward all-in-one chemo-photodynamic therapy

(2019) Jilian Wu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Single small molecule-assembled nanoparticles mediate efficient oral drug delivery

(2019) Xin Yang et al.   Nano Research

GSH-Activatable NIR Nanoplatform with Mitochondria Targeting for Enhancing Tumor-Specific Therapy

(2019) Guoliang Yang et al.   ACS Applied Materials & Interfaces

Dynamic-Reversible Photoacoustic Probe for Continuous Ratiometric Sensing and Imaging of Redox Status in Vivo

(2019) Judun Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Near-Infrared Photosensitizer with Aggregation-Induced Emission for Imaging-Guided Photodynamic Therapy in Multiple Xenograft Tumor Models

(2019) Jun Dai et al.   ACS Nano

Molecular Self-Assembly of Bioorthogonal Aptamer-Prodrug Conjugate Micelles for Hydrogen Peroxide and pH-Independent Cancer Chemodynamic Therapy

(2019) Wenjing Xuan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxyhemoglobin-monitoring photodynamic theranostics with an 808 nm-excited upconversion optical nanoagent

(2018) Wenkai Fang et al.   CHEMICAL ENGINEERING JOURNAL

Conjugation Chemistry-Dependent T-Cell Activation with Spherical Nucleic Acids

(2018) Kacper Skakuj et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Smart Nanoreactors for pH-Responsive Tumor Homing, Mitochondria-Targeting, and Enhanced Photodynamic-Immunotherapy of Cancer

(2018) Guangbao Yang et al.   NANO LETTERS

Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance

(2018) Xiang Ling et al.   NANO LETTERS

A Visible and Near-Infrared, Dual-Channel Fluorescence-On Probe for Selectively Tracking Mitochondrial Glutathione

(2018) Zhiqiang Xu et al.   Chem

A small molecule nanodrug assembled of dual-anticancer drug conjugate for synergetic cancer metastasis therapy

(2018) Chao Li et al.   BIOCONJUGATE CHEMISTRY

Chemotaxis-Instructed Intracellular Staphylococcus aureus Infection Detection by a Targeting and Self-Assembly Signal-Enhanced Photoacoustic Probe

(2018) Qian Cai et al.   NANO LETTERS

Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment

(2018) Xiangdong Xue et al.   Nature Communications

Glutathione and H2O2 consumption promoted photodynamic and chemotherapy based on biodegradable MnO2–Pt@Au25 nanosheets

(2018) Huiting Bi et al.   CHEMICAL ENGINEERING JOURNAL

Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy

(2018) Man Kyu Shim et al.   JOURNAL OF CONTROLLED RELEASE

Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo

(2017) Yan Wen et al.   Nanoscale

Multifunctional Nanoparticles Self-Assembled from Small Organic Building Blocks for Biomedicine

(2016) Pengyao Xing et al.   ADVANCED MATERIALS

Tumor microenvironment and cancer therapy resistance

(2016) Yu Sun   CANCER LETTERS

A small molecule nanodrug consisting of amphiphilic targeting ligand–chemotherapy drug conjugate for targeted cancer therapy

(2016) Quanbing Mou et al.   JOURNAL OF CONTROLLED RELEASE

Building nanostructures with drugs

(2016) Wang Ma et al.   Nano Today

Nanomedicines for renal disease: current status and future applications

(2016) Nazila Kamaly et al.   Nature Reviews Nephrology

Enhanced chemiluminescence detection of glutathione based on isoluminol-PSM nanoparticles probe

(2016) Xiaoting Ji et al.   TALANTA

Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer

(2016) Fangyuan Zhou et al.   Theranostics

Improving drug delivery to solid tumors: Priming the tumor microenvironment

(2015) Iftikhar Ali Khawar et al.   JOURNAL OF CONTROLLED RELEASE

Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell death

(2015) Joungyoun Noh et al.   Nature Communications

In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent

(2014) Tao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifunctional Upconversion Mesoporous Silica Nanostructures for Dual Modal Imaging and In Vivo Drug Delivery

(2013) Chunxia Li et al.   Small

Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate

(2012) Motao Zhu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biodegradable polymer − cisplatin(IV) conjugate as a pro-drug of cisplatin(II)

(2011) Haihua Xiao et al.   BIOMATERIALS

Glutathione in Cancer Cell Death

(2011) Angel L. Ortega et al.   Cancers