Review
Medicine, Research & Experimental
Jiaxin Li, Cong Li, Yu Huang, Peng Guan, Desheng Huang, Honghua Yu, Xiaohong Yang, Lei Liu
Summary: Ophthalmic epidemiology focuses on the prevalence, distribution, and other factors of human eye diseases, with genetics playing a vital role. Mendelian randomization (MR) is an emerging method that reveals causal relationships between exposure and eye diseases using genetic variations. Many MR studies have identified potential causal associations, providing opportunities for further research and intervention development, with some limitations to consider.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Jiayi Shen, Huaqiang Zhou, Jiaqing Liu, Yaxiong Zhang, Ting Zhou, Yunpeng Yang, Wenfeng Fang, Yan Huang, Li Zhang
Summary: This study constructed a modifiable risk factors atlas of lung cancer using Mendelian randomization framework, finding higher socioeconomic status to be significantly correlated with lower lung cancer risk, while smoking, TV watching time, and certain fatty acids in blood associated with higher risk.
Review
Endocrinology & Metabolism
Jian-Zeng Guo, Qi-Jun Wu, Fang-Hua Liu, Chang Gao, Ting-Ting Gong, Gang Li
Summary: This article introduces the application of Mendelian randomization (MR) analysis in the study of endometrial cancer (EC). Through MR analysis, it is found that type 2 diabetes, uterine fibroids, higher body mass index, higher plasminogen activator inhibitor-1 (PAI-1), higher fasting insulin, longer telomere length, higher testosterone, and higher plasma cortisol levels are associated with increased risk of EC, while later age of menarche, higher circulatory tumor necrosis factor, higher low-density lipoprotein cholesterol, and higher sex hormone-binding globulin levels are associated with reduced risk of EC.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Yufeng Xie, Yanfang Li, Jianmei Zhang, Yun Chen, Rong Ren, Lu Xiao, Min Chen
Summary: This study utilized a two-sample Mendelian randomization analysis to explore the causal role of blood metabolites in the risk of gout. It identified 14 metabolites, particularly hexadecanedioate, with a significant causal effect on gout. The findings suggest that examining specific blood metabolites could be a feasible strategy for screening individuals at a higher risk of gout.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Genetics & Heredity
Wen Liu, Miaomiao Wang, Jianyong Liu, Qiuxia Yan, Ming Liu
Summary: This study used a bidirectional Mendelian randomization design to assess the causal associations between modifiable risk factors and the risk of kidney stones. The results showed significant associations between serum calcium, serum 25(OH)D, total triglycerides, fasting insulin, urine pH, and the risk of kidney stones. Meta-analyses of data from the FinnGen consortium and UK Biobank supported these associations.
BMC MEDICAL GENOMICS
(2023)
Article
Genetics & Heredity
Thitiya Lukkunaprasit, Sasivimol Rattanasiri, Boonsong Ongphiphadhanakul, Gareth J. McKay, John Attia, Ammarin Thakkinstian
Summary: This study used Mendelian Randomization to investigate the causal relationship between genetically predicted serum urate and cardiovascular risk factors. The results showed a significant and robust causal effect of urate on HDL-C, suggesting urate may be a novel cardiac risk factor.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
S. van Oort, J. W. J. Beulens, A. J. van Ballegooijen, S. Burgess, S. C. Larsson
Summary: The study found that most of the Life's Simple 7 modifiable risk factors are causally related to longevity. Strategies for prevention should focus on modifying these risk factors and reducing education inequalities to improve cardiovascular health and longevity.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jian Zhao, Jing Zeng, Cairong Zhu, Xuechao Li, Dong Liu, Jun Zhang, Fei Li, Giovanni Targher, Jian-Gao Fan
Summary: This study used Mendelian randomization analysis to uncover a causal relationship between higher alanine and lower glutamine levels and an increased risk of developing MAFLD, providing potential targets for MAFLD prevention or treatment.
Article
Medicine, General & Internal
Weifeng Shang, Hang Qian, Sheng Zhang, Mingyang Yuan, Xiaojun Pan, Sisi Huang, Jiao Liu, Dechang Chen
Summary: This study used Mendelian randomization analysis to examine the causal relationship between blood metabolites and sepsis risk. The findings identified four blood metabolites that are causally associated with a lower risk of sepsis, providing novel perspectives into the development mechanism of sepsis.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Oncology
Hongzhan Jiang, Yi Li, Jiali Shen, Huihui Lin, Siyue Fan, Rongliang Qiu, Jiaxi He, Ende Lin, Lijuan Chen
Summary: This study used Mendelian randomization methodology to investigate the causative impact of smoking on thyroid cancer incidence. The results did not find evidence of a causative link between smoking exposure and elevated incidence rates of thyroid malignancies.
Article
Multidisciplinary Sciences
Jiwoo Lee, Sakari Jukarainen, Antti Karvanen, Padraig Dixon, Neil M. Davies, George Davey Smith, Pradeep Natarajan, Andrea Ganna
Summary: Understanding the causal impact of clinical risk factors on healthcare costs is crucial for evaluating healthcare interventions. Using a genetically-informed design, this study found that waist circumference, body mass index, and blood pressure have significant causal impact on healthcare costs. Increased waist circumference is a major contributor to annual total healthcare costs.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Zixin Wei, Biying Yang, Tiantian Tang, Zijing Xiao, Fengzhan Ye, Xiaoyu Li, Shangbin Wu, Jin-gang Huang, Shanping Jiang
Summary: Using Mendelian randomization analysis, this study found associations between gut microbiota and the risk of breast and prostate cancer. Specifically, higher abundance of the genus Sellimonas was associated with an increased risk of estrogen receptor-positive breast cancer, while higher abundance of the class Alphaproteobacteria was associated with a decreased risk of prostate cancer.
Article
Endocrinology & Metabolism
Minghui Liu, Jian Wu, Meng Gao, Yongchao Li, Weiping Xia, Youjie Zhang, Jinbo Chen, Zhiyong Chen, Zewu Zhu, Hequn Chen
Summary: This study provides Mendelian randomization evidence supporting causal associations of many modifiable risk factors with kidney stones. Sedentary lifestyle, obesity, smoking, and type 2 diabetes mellitus are mediating factors in the causal relationship between educational attainment and kidney stones. These modifiable factors should receive more attention to prevent kidney stones.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Jingru Song, Wenjing Chen, Wei Ye
Summary: This study investigated the connection between stroke and gastrointestinal disorders, and found that genetic predisposition to ischemic stroke and its subtypes is not associated with gastrointestinal disorders. However, complications of deep intracerebral hemorrhage are associated with a higher risk of peptic ulcer disease and gastroesophageal reflux disease.
FRONTIERS IN NEUROLOGY
(2023)
Article
Genetics & Heredity
Minxiao Jiang, Liangliang Ren, Songzan Chen, Gonghui Li
Summary: The study utilizing Mendelian randomization did not find a significant association between serum uric acid levels and cancer risk. Analysis of eight common site-specific cancers did not show any significant correlation with serum uric acid levels.
FRONTIERS IN GENETICS
(2021)
Article
Rheumatology
Jing Ni, Ji-Xiang Huang, Peng Wang, Yi-Xuan Huang, Kang-Jia Yin, Tian Tian, Han Cen, Cong Sui, Hai-Feng Pan
Summary: This study found that there is a correlation between arthritis and pulmonary diseases, with arthritis patients being more likely to develop chronic lung diseases and asthma. Arthritis patients also exhibited lower peak expiratory flow. Early detection and treatment of pulmonary abnormalities among arthritis patients are important for reducing the global burden of arthritis.
CLINICAL RHEUMATOLOGY
(2023)
Article
Engineering, Environmental
Ying Pan, Yang Fang, Yue Chen, Cong Chen, Ruo-Di Zhang, Xi Fang, Yan Zhao, Ling-Qiong Jiang, Jing Ni, Peng Wang, Hai-Feng Pan
Summary: This study investigates the relationship between exposure to particulate matter (PM) air pollutants and the risk of systemic lupus erythematosus (SLE) admission. The results show positive associations between PM2.5 and PM10 exposures and the risk of SLE admission. Subgroup analyses reveal that this association is more significant in women, individuals over 65 years old, and during the cold season.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Chemistry, Analytical
Yanjuan Wang, Ning Tong, Fengqi Li, Kai Zhao, Deguang Wang, Yijie Niu, Fengqiang Xu, Jiale Cheng, Junsheng Wang
Summary: In this study, a microfluidic trapping system based on AC dielectrophoresis (DEP) technology was proposed for precise trapping and release of specific microparticles. Numerical simulation and experimental verification were conducted to confirm the effectiveness of the designed system, contributing to the application of cell trapping and manipulation, as well as single-cell analysis.
Review
Surgery
Yu-Chen Liu, Chuan-Lu Shen, Zi-Yue Fu, Yu-Chen Zhang, Yan-Xun Han, Bang-Jie Chen, Yuan Jiang, Si-Yue Yin, Zhi Tao, Shu-Yan Sheng, Jian-Peng Wang, Bing-Yu Liang, Liang Zhang, Dong Wang, Kai-Le Wu, Hai-Feng Pan, Ye-Hai Liu
Summary: The effectiveness of intraoperative nerve monitoring (IONM) in endoscopic thyroid surgery was explored in this study. The results showed that IONM significantly reduced the incidence of transient recurrent laryngeal nerve (RLN) palsy, but did not significantly reduce the incidence of permanent RLN palsy. However, there was a significant reduction in total RLN palsy. Additionally, IONM effectively reduced the localization time of the RLN and increased the identification rate of the superior laryngeal nerve. Therefore, the use of IONM is recommended for malignant tumors.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Rheumatology
Fan Cao, Da-Peng Li, Guo-Cui Wu, Yi-Sheng He, Yu-Chen Liu, Jing-Jing Hou, Qin-Yu Ni, Li-Ming Tao, Zheng-Xuan Jiang, Hai-Feng Pan
Summary: This study provides an overview and analysis of the temporal trends in the prevalence of musculoskeletal disorders in women of childbearing age at global, regional, and national levels over the past 30 years. The results indicate a favorable overall trend in the prevalence of these disorders globally, but there are still 138 countries experiencing unfavorable rising trends. This raises concerns about the timely achievement of the Sustainable Development Goals.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Editorial Material
Immunology
Xiao Hu, Jie-Bing Wang, Yan Zhao, Yang Fang, Cong Chen, Man Ge, Yi-Qing Xu, Zhao-Xing Gao, Hai-Peng Wang, Peng Wang
AUTOIMMUNITY REVIEWS
(2023)
Article
Immunology
Yuchen Liu, Zhechen Wu, Ziyue Fu, Yanxun Han, Jianpeng Wang, Yanqiang Zhang, Bingyu Liang, Ye Tao, Yuchen Zhang, Chuanlu Shen, Yidan Xu, Siyue Yin, Bangjie Chen, Yehai Liu, Haifeng Pan, Zhang Liang, Kaile Wu
Summary: This study investigated focal adhesion-related genes (FARGs) in head and neck squamous cell carcinoma (HNSCC) and identified two molecular subtypes. A FARG signature model consisting of 9 genes was developed and proven to be a reliable prognostic predictor for HNSCC patients. Furthermore, FARGs were found to be associated with immune infiltration, gene mutation status, and chemosensitivity, providing potential targets for targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xi Fang, Cong Chen, Zhi-Xin Wang, Yan Zhao, Ling-Qiong Jiang, Yang Fang, Ruo-Di Zhang, Hai-Feng Pan, Sha-Sha Tao
Summary: The purpose of this study was to evaluate the serum Dickkopf-1 (DKK-1) level in ankylosing spondylitis (AS) patients compared to normal controls and to test the causal relationship between DKK-1 and AS risk. The meta-analysis of 40 studies showed no significant difference in DKK-1 serum level between AS patients and normal controls. The MR analysis also demonstrated no significant association between DKK-1 serum level and AS risk.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Xiu-Ya Xing, Yan Zhao, Napoleon Bellua Sam, Jing-Qiao Xu, Ye-Ji Chen, Wei Xu, Hua-Dong Wang, Zhi-Rong Liu, Hai-Feng Pan
Summary: The study aimed to understand the prevalence and specific measures of salt reduction behavior, the variables affecting salt reduction behavior, and the reasons for not practicing salt reduction behavior in Anhui Province. It was found that residents of Anhui Province have low knowledge about salt reduction, and age, gender, education level, hypertension, and marital status are the main determinants.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Environmental Sciences
Cong Chen, Yi-Sheng He, Sha-Sha Tao, Yang Fang, Ruo-Di Zhang, Xi Fang, Ling-Qiong Jiang, Yan Zhao, Harry Asena Musonye, Jin-Hui Tao, Hai-Feng Pan
Summary: This study aimed to investigate the short-term correlation between meteorological factors and dermatomyositis (DM) outpatient visits. The findings showed significant associations between low temperature, humidity, diurnal temperature range, and temperature change and the risk of DM outpatient visits. Furthermore, women were more susceptible to high humidity and low temperature change, while the elderly were more susceptible to low temperature. In conclusion, exposure to low temperature, extreme humidity, and temperature changes (especially high diurnal temperature range and low temperature change) were associated with an increased risk of DM outpatient visits.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Computer Science, Artificial Intelligence
Yongrui Chen, Huiying Li, Guilin Qi, Tianxing Wu, Tenggou Wang
Summary: Query graph construction aims to generate a correct SPARQL query to answer natural language questions on a knowledge graph. Existing methods face challenges in handling complex questions including complicated SPARQL syntax, huge search space, and locally ambiguous query graphs. This paper proposes a novel end-to-end approach that leverages a unified graph grammar called AQG and hierarchical autoregressive decoding to construct query graphs effectively. Experimental results demonstrate that the proposed method significantly improves the state-of-the-art performance on complex KGQA benchmarks.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Environmental Sciences
Wuli Li, Xirun Zong, Yi-Sheng He, Tiantian Meng, Ying Tang, Qi Yang, Qing Huang, Yuanyin Wang, Song Li, Hai-Feng Pan
Summary: Evidence suggests a possible association between ambient air pollutants and oral diseases. The present study aimed to investigate the relationship between short-term exposure to air pollution and outpatient visits for pulpitis. The results showed that exposure to NO2, PM2.5, and CO were positively correlated with an increased risk of pulpitis outpatient visits, while exposure to O-3 was associated with a decreased risk. Age and season were found to be effect modifiers of these associations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Mathematics, Interdisciplinary Applications
Wenqiang Li, Yuda Hu, Zhe Li
Summary: This paper investigates the magneto-aero-elastic nonlinear resonances, bifurcations, and chaos of conductive circular plates spinning in air and magnetic fields for superharmonic and subharmonic responses. Electromagnetic forces on the in-plane are described using electromagnetic field theory, while an aerodynamic model is used to capture the aerodynamic forces on the plates. Taking into account geometric nonlinearity and centrifugal tensioning, the governing equations for spinning conductive circular plates are derived. The Galerkin method is employed to derive the transverse nonlinear vibration equations for spinning plates with clamped-edge, and amplitude-frequency equations for subharmonic and superharmonic responses are obtained using the multiple scales approach. Numerical calculations reveal the influence of important parameters on the amplitude frequency characteristics, showing the presence of complex intermittency, period-doubling, and chaotic dynamical behaviors.
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
(2023)
Article
Computer Science, Information Systems
Deguang Wang, Xi Wang, Jing Yang, Zhiwu Li
Summary: This article investigates fault diagnosis of hierarchical discrete event systems (HDES) using state-tree structures (STS). It presents a symbolic approach of diagnoser construction based on predicates and predicate transformers, with the advantages of STS and on-the-fly analysis technique. The state space of the diagnoser is compressed and managed using BDD representation of predicates, reducing computer memory space. The proposed on-the-fly algorithm based on depth-first search unfolds the STS model gradually for level-by-level diagnosability analysis.
IEEE SYSTEMS JOURNAL
(2023)
Article
Environmental Sciences
Yi-Sheng He, Zheng-Dong Wu, Gui-Hong Wang, Xiaohu Wang, Yong-Jun Mei, Cong Sui, Sha-Sha Tao, Chan-Na Zhao, Peng Wang, Jing Ni, Hai-Feng Pan
Summary: This study conducted a multi-city time-series analysis in Anhui Province, China to explore the relationship between short-term exposure to air pollutants and the risk of outpatient visits for osteoarthritis (OA). The results showed that particulate matter (PM2.5 and PM10) was associated with increased risk of OA outpatient visits, while gaseous pollutants (SO2, O3, and CO) did not show any significant association. Additionally, the risk of OA varied between different seasons.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
