Article
Multidisciplinary Sciences
Kristen N. Brown, Anthony Castleberry, Poonam Velagapudi
Summary: Right ventricular shock is a significant cause of morbidity and mortality worldwide. Treatment options include medical management and mechanical circulatory support. The percutaneous right ventricular assist device is a unique mechanical support device that temporarily offloads the right ventricle and shunts blood to the pulmonary artery. This device allows for percutaneous insertion and removal, as well as patient ambulation.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Respiratory System
Takashi Harano, Ernest G. Chan, Masashi Furukawa, Pedro Reck dos Santos, Matthew R. Morrell, Penny L. Sappington, Pablo G. Sanchez
Summary: Peripherally cannulated oxyRVAD with percutaneous dual-lumen venous cannula may serve as an ambulatory bridge for lung transplantation. It is unknown whether oxyRVAD is feasible as a long-term bridge to lung transplantation.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Engineering, Biomedical
Asad A. A. Usman, Audrey E. E. Spelde, Michael Ibrahim, Marisa Cevasco, Christian Bermudez, Emily MacKay, Sameer Khandhar, Wilson Szeto, William Vernick, Jacob Gutsche
Summary: This study retrospectively investigates the use of RA-PA DLSC RVAD in patients, highlighting the importance of echocardiographic measures in evaluating RV function progression, improvement in vasoactive infusion requirements, and ventilator parameters.
Article
Engineering, Biomedical
Lindsay A. Ritter, Mouaz Haj Bakri, Heather C. Fahey, Kavya K. Sanghavi, Akhil Kallur, Fred Bien-Aime, Tariq Sallam, Aiman Alassar, Keki Balsara, Hiroto Kitahara, Thomas E. MacGillivray, Akram M. Zaaqoq
Summary: Refractory right ventricular failure is associated with high morbidity and mortality. Extracorporeal membrane oxygenation (ECMO) is a treatment option when medical interventions fail. A retrospective analysis comparing two configurations, V-PA and C-PA, showed no difference in survival after hospital discharge, but the C-PA group had shorter ICU stay, shorter duration of mechanical ventilation, lower incidence of bleeding, and lower incidence of combined ischemic events.
Editorial Material
Cardiac & Cardiovascular Systems
Tanous Aoun, Guillaume Baudry, Gilles Rioufol, Jean Francois Obadia, Matteo Pozzi
Summary: Myocardial recovery in LVAD patients is rare, and surgical explantation is risky. This report highlights the use of a Watchman closure device for deactivation of a HeartMate 3 LVAD.
ANNALS OF THORACIC SURGERY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Masashi Kawabori, Taylor Nordan, Navin K. Kapur, Gregory S. Couper
Summary: Right ventricular failure has a negative impact on prognosis post left ventricular assist device implantation. However, a strategy for primary prevention of right ventricular failure in high-risk patients has been proposed.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Jared P. Beller, J. Hunter Mehaffey, Zachary K. Wegermann, Maria Grau-Sepulveda, Sean M. O'Brien, J. Matthew Brennan, Vinod Thourani, Vinay Badhwar, Francis D. Pagani, Gorav Ailawadi, Leora T. Yarboro, Nicholas R. Teman
Summary: Patients with severe right ventricular failure during durable left ventricular assist device implantation may benefit from the use of RVAD over VA-ECMO. Regardless of the type of support, initiation at the index operation was associated with improved outcomes.
ANNALS OF THORACIC SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Asad A. Usman, Audrey E. Spelde, Salim E. Olia, Marisa Cevasco, Christian Bermudez, John Haddle, Michael Ibrahim, Wilson Szeto, William Vernick, Jacob Gutsche
Summary: This article describes the use of a new dual lumen percutaneous right ventricular assist device (RVAD) cannula, which is designed to maximize right heart drainage and limit suck-down events. In clinical practice, this cannula can be used for the treatment of acute right ventricular failure.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Ander Dorken Gallastegi, Elif B. Hoscoskun, Umit Kahraman, Burcu Yagmur, Sanem Nalbantgil, Cagatay Engin, Tahir Yagdi, Mustafa Ozbaran
Summary: This study evaluated long-term survival and hospital readmissions after LVAD implantation via thoracotomy with outflow cannula anastomosis to the descending aorta and found no significant differences compared to standard implantation in terms of survival and readmissions.
ANNALS OF THORACIC SURGERY
(2022)
Article
Engineering, Biomedical
Leonie Korn, Seraina Dual, Joeran Rixen, Mirko Meboldt, Steffen Leonhardt, Marianne Schmid Daners, Marian Walter
Summary: The study aimed to integrate ultrasound and impedance volume measurement techniques, overcoming the need for recalibration in single sensor modality. Results showed that the dual-modality approach provided high accuracy and robustness in ventricular volume measurement, indicating its potential clinical significance in monitoring heart failure patients with VADs.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Review
Cardiac & Cardiovascular Systems
Aleksandra Bartnik, Joanna Pepke-Zaba, Stephen P. Hoole, Paul White, Madalina Garbi, John G. Coghlan, Fouad Taghavi, Steven Tsui, Jonathan Weir-McCall
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a condition that occurs in some patients with prior acute pulmonary embolism, characterized by shortness of breath, persistently elevated pulmonary pressures, and right heart failure. Surgical pulmonary endarterectomy (PEA) is effective for patients with proximal disease distribution, while balloon pulmonary angioplasty (BPA) and medical therapy are options for those with inoperable disease. Current evaluation of pulmonary hemodynamics does not accurately reflect patient symptoms, and further research is needed on how to manage symptomatic patients without pulmonary hypertension.
Review
Cardiac & Cardiovascular Systems
Michael Essandoh, Nicolas Kumar, Nasir Hussain, Adam A. Dalia, David Wang, Omar Al-Qudsi, David Wilsak, David Stahl, Amar Bhatt, Hamdy Awad, Tamara R. Sawyer, Manoj H. Iyer
Summary: This systematic review demonstrates the utility of PAPi as a clinical predictor of RVF after LVAD implantation. Based on our findings, we recommend that PAPi be used in conjunction with traditional hemodynamic parameters when risk stratifying LVAD recipients for RVF.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Cardiac & Cardiovascular Systems
Claudio A. Bravo, Andrew G. Navarro, Karanpreet K. Dhaliwal, Maziar Khorsandi, Jeffrey E. Keenan, Parvathi Mudigonda, Kevin D. O'Brien, Claudius Mahr
Summary: Left ventricular assist device (LVAD) therapy is a life-saving option for patients with advanced heart failure who do not respond to medical treatment. However, a significant percentage of LVAD patients develop right heart failure (RHF), which is associated with poor outcomes. The mechanisms of RHF are complex, involving patient factors, surgical factors, and hemodynamic factors. Despite advances in surgical techniques and LVAD technology, RHF remains a major cause of morbidity and mortality among LVAD patients. Current medical therapies for RHF are limited, and cardiac transplantation or supportive management are the only options for these patients. Efforts to predict the risk of RHF in LVAD patients have been challenging, with varying definitions of RHF in different studies. Additionally, most research in this field has focused on early-onset RHF, while late-onset RHF is increasingly recognized as a significant problem. This review aims to describe the unique physiology of the right ventricle and the changes caused by LVADs that may contribute to both early- and late-onset RHF. The available treatments for RHF, including mechanical circulatory support and medical therapies, will also be analyzed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Yue Qu, Anton Y. Peleg, David McGiffin
Summary: Ventricular assist device (VAD)-specific infections, particularly driveline infections, are a concerning complication of VAD implantation due to biofilm formation and migration. Despite multiple preventative strategies, driveline infections still have a high prevalence and unsatisfactory treatment outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Gaurav Gulati, E. Wilson Grandin, David DeNofrio, Jenica N. Upshaw, Amanda R. Vest, Michael S. Kiernan
Summary: The postoperative hemodynamic status of LVAD patients is associated with early RHF, mortality, and GIB, but not with stroke risk.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Letter
Hematology
Anna Weatherill, Mike Laffan, Mihaela Gasper, Paolo Bianchi, Maurizio Passariello, Suveer Singh, James Doyle, Brijesh Patel, Stephane Ledot, Benjamin Garfield, Deepa J. Arachchillage
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Respiratory System
Lucilla Piccari, Stephen John Wort, Federica Meloni, Monica Rizzo, Laura C. Price, Lavinia Martino, Elena Salvaterra, Laura Scelsi, Manuel Lopez Meseguer, Isabel Blanco, Adriana Callari, Virginia Perez Gonzalez, Fabio Tuzzolino, Colm McCabe, Diego Agustin Rodriguez Chiaradia, Patrizio Vitulo
Summary: The impact of borderline pulmonary hypertension (PH) on survival in patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) remains unclear. However, in ILD, any level of PH is associated with worse survival, while in COPD, only severe PH leads to poorer outcomes.
Editorial Material
Respiratory System
Laura C. Price, Jason Weatherald
EUROPEAN RESPIRATORY JOURNAL
(2023)
Letter
Respiratory System
Sri Harsha Dintakurti, Sanjana Kamath, Ciara Mahon, Suveer Singh, Bhavin Rawal, Simon P. G. Padley, Anand Devaraj, Laura C. Price, Sujal R. Desai, Tom Semple, Carole A. Ridge
Editorial Material
Critical Care Medicine
Brijesh V. Patel, Teresa M. L. Lee, Kieran O'Dea
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Respiratory System
Chinthaka B. Samaranayake, Aleksander Kempny, Robert Naeije, Michael Gatzoulis, Laura C. Price, Konstantinos Dimopoulos, Lan Zhao, Stephen J. Wort, Colm McCabe
EUROPEAN RESPIRATORY JOURNAL
(2023)
Letter
Respiratory System
Chinthaka B. Samaranayake, Christopher Warren, Serena Rhamie, Gulam Haji, S. John Wort, Laura C. Price, Colm McCabe, James H. Hull
Editorial Material
Respiratory System
Laura C. Price, Colm McCabe, Jason Weatherald
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Chinthaka Bhagya Samaranayake, John Upham, Khoa Tran, Luke S. Howard, Sean Nguyen, Myo Lwin, James Anderson, Sudhir Wahi, Laura C. Price, Stephen Wort, Wei Li, Colm McCabe, Gregory J. Keir
Summary: This study aimed to evaluate the RV exercise adaptation in survivors of intermediate and high-risk acute PE. The results showed that about one-third of patients exhibited impaired RV adaptation during exercise, and RV-PA uncoupling was associated with increased ventilatory inefficiency, reduced peak exercise oxygen saturation, and decreased peak oxygen pulse. Therefore, combining stress echocardiography and CPET can enable more accurate phenotyping of patients with persistent symptoms following acute PE and allow timely detection of long-term complications.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Letter
Respiratory System
Laura C. Price, Benjamin Garfield, Chloe Bloom, Nidhish Jeyin, Daniel Nissan, James H. Hull, Brijesh Patel, Gisli Jenkins, Simon Padley, William Man, Suveer Singh, Carole A. Ridge
