A Missing Link in Multisubstituted Pyrrolidines: Remote Stereocontrol Forged by Rhodium‐Alkyl Nitrene

Mechanism-Guided Development of Transition-Metal-Catalyzed C–N Bond-Forming Reactions Using Dioxazolones as the Versatile Amidating Source

(2021) Seung Youn Hong et al.   ACCOUNTS OF CHEMICAL RESEARCH

Asymmetric Synthesis of Enantiopure Pyrrolidines by C(sp 3 )−H Amination of Hydrocarbons

(2021) Yanis Lazib et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalyst‐Controlled Chemoselective Nitrene Transfers

(2021) Hidetoshi Noda et al.   HELVETICA CHIMICA ACTA

Direct, Catalytic α-Alkylation of N-Heterocycles by Hydroaminoalkylation: Substrate Effects for Regiodivergent Product Formation

(2021) Rebecca C. DiPucchio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α,α′-C–H Bond Difunctionalization of Unprotected Alicyclic Amines

(2021) Daniel A. Valles et al.   ORGANIC LETTERS

Imbuing an Old Heterocycle with the Power of Modern Catalysis: An Isoxazolidin-5-one Story

(2021) Hidetoshi Noda   CHEMICAL & PHARMACEUTICAL BULLETIN

Ligand-Enabled, Copper-Catalyzed Electrophilic Amination for the Asymmetric Synthesis of β-Amino Acids

(2021) Raj K. Tak et al.   ORGANIC LETTERS

Nickel-Catalyzed Cross-Electrophile Reductive Couplings of Neopentyl Bromides with Aryl Bromides

(2020) Soumik Biswas et al.   JOURNAL OF ORGANIC CHEMISTRY

O-Benzoylhydroxylamines as Alkyl Nitrene Precursors: Synthesis of Saturated N-Heterocycles from Primary Amines

(2020) Hidetoshi Noda et al.   ORGANIC LETTERS

Copper-Catalyzed N−F Bond Activation for Uniform Intramolecular C−H Amination Yielding Pyrrolidines and Piperidines

(2019) Daniel Bafaluy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Olefin Amine (OLA) Reagents for the Synthesis of Bridged Bicyclic and Spirocyclic Saturated N-Heterocycles by Catalytic HAT Reactions

(2019) Ya-Yi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Traceless Electrophilic Amination for the Synthesis of Unprotected Cyclic β-Amino Acids

(2019) Jin-Sheng Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lewis Base Assisted Lithium Brønsted Base Catalysis: A New Entry for Catalytic Asymmetric Synthesis of β2,2-Amino Acids

(2019) Fuyuki Amemiya et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Characterization of a Reactive Rh2 Nitrenoid by Crystalline Matrix Isolation

(2019) Anuvab Das et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Unprotected Spirocyclic β-Prolines and β-Homoprolines by Rh-Catalyzed C–H Insertion

(2019) Miguel Espinosa et al.   ORGANIC LETTERS

Asymmetric Synthesis of α-Trifluoromethylthio-β-Amino Acids under Phase Transfer Catalysis

(2019) Vito Capaccio et al.   ORGANIC LETTERS

Selective formation of γ-lactams via C–H amidation enabled by tailored iridium catalysts

(2018) Seung Youn Hong et al.   SCIENCE

Construction of Isoxazolidin-5-ones with a Tetrasubstituted Carbon Center: Enantioselective Conjugate Addition Mediated by Phase-Transfer Catalysis

(2018) Timothée Cadart et al.   ADVANCED SYNTHESIS & CATALYSIS

N-Heterocyclic Carbene Iron(III) Porphyrin-Catalyzed Intramolecular C(sp3 )-H Amination of Alkyl Azides

(2018) Ka-Pan Shing et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploiting β-Amino Acid Enolates in Direct Catalytic Diastereo- and Enantioselective C-C Bond Forming Reactions

(2018) Jin-Sheng Yu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Synthesis of N-Heterocycles via Direct C(sp3)–H Amination Using an Air-Stable Iron(III) Species with a Redox-Active Ligand

(2017) Bidraha Bagh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition Metal Free C–N Bond Forming Dearomatizations and Aryl C–H Aminations by in Situ Release of a Hydroxylamine-Based Aminating Agent

(2017) Joshua J. Farndon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct α-C–H bond functionalization of unprotected cyclic amines

(2017) Weijie Chen et al.   Nature Chemistry

Catalytic Enantioselective Syntheses of Isoxazolidin-5-ones

(2017) Jean-François Brière et al.   SYNTHESIS-STUTTGART

Recent Developments in the Stereoselective Synthesis of Nitrogen-Containing Heterocycles usingN-Acylimines as Reactive Substrates

(2016) Enrico Marcantoni et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Phase-Transfer Catalyzed α-Sulfanylation of Isoxazolidin-5-ones: An Entry to β2,2-Amino Acid Derivatives

(2016) Timothée Cadart et al.   CHEMISTRY-A EUROPEAN JOURNAL

Robust and Porous β-Diketiminate-Functionalized Metal–Organic Frameworks for Earth-Abundant-Metal-Catalyzed C–H Amination and Hydrogenation

(2016) Nathan C. Thacker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalyst-Controlled and Tunable, Chemoselective Silver-Catalyzed Intermolecular Nitrene Transfer: Experimental and Computational Studies

(2016) Nicholas S. Dolan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The ChEMBL database in 2017

(2016) Anna Gaulton et al.   NUCLEIC ACIDS RESEARCH

Dirhodium-catalyzed C-H arene amination using hydroxylamines

(2016) M. P. Paudyal et al.   SCIENCE

An Iodine-Catalyzed Hofmann-Löffler Reaction

(2015) Claudio Martínez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Takuya Hashimoto et al.   CHEMICAL REVIEWS

α-Arylation of Saturated Azacycles and N-Methylamines via Palladium(II)-Catalyzed C(sp3)–H Coupling

(2015) Jillian E. Spangler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rings in Drugs

(2014) Richard D. Taylor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct Stereospecific Synthesis of Unprotected N-H and N-Me Aziridines from Olefins

(2014) Jawahar L. Jat et al.   SCIENCE

Silver-catalysed direct amination of unactivated C–H bonds of functionalized molecules

(2014) Mingyu Yang et al.   Nature Communications

One-Pot Asymmetric Nitro-Mannich/Hydroamination Cascades for the Synthesis of Pyrrolidine Derivatives: Combining Organocatalysis and Gold Catalysis

(2014) David M. Barber et al.   ACS Catalysis

Organocatalysed decarboxylative protonation process from Meldrum's acid: enantioselective synthesis of isoxazolidinones

(2013) Tony Tite et al.   CHEMICAL COMMUNICATIONS

A General Mechanism for the Copper- and Silver-Catalyzed Olefin Aziridination Reactions: Concomitant Involvement of the Singlet and Triplet Pathways

(2013) Lourdes Maestre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination

(2013) E. T. Hennessy et al.   SCIENCE

Metal-Catalyzed Nitrogen-Atom Transfer Methods for the Oxidation of Aliphatic C–H Bonds

(2012) Jennifer L. Roizen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Supramolecular Binding Thermodynamics by Dispersion-Corrected Density Functional Theory

(2012) Stefan Grimme   CHEMISTRY-A EUROPEAN JOURNAL

Direct α-Functionalization of Saturated Cyclic Amines

(2012) Emily A. Mitchell et al.   CHEMISTRY-A EUROPEAN JOURNAL

Heterocycle Synthesis via Direct C–H/N–H Coupling

(2011) Enrico T. Nadres et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Efficient Syntheses of Azetidines, Pyrrolidines, and Indolines via Palladium Catalyzed Intramolecular Amination of C(sp3)–H and C(sp2)–H Bonds at γ and δ Positions

(2011) Gang He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyanocuprates Convert Carboxylic Acids Directly into Ketones

(2011) Douglas T Genna et al.   ORGANIC LETTERS

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

A mechanistic analysis of the Rh-catalyzed intramolecular C–H amination reaction

(2008) Kristin Williams Fiori et al.   TETRAHEDRON