Goldilocks and the Three Trials: Clinical Trials Targeting the αvβ6 Integrin in Idiopathic Pulmonary Fibrosis

Randomized Phase IIa Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis

(2022) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys

(2020) Mayur S Mitra et al.   TOXICOLOGICAL SCIENCES

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

(2020) Alison E. John et al.   Nature Communications

Integrin αvβ6: Structure, function and role in health and disease

(2018) Leeni Koivisto et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease

(2015) Gauri Saini et al.   EUROPEAN RESPIRATORY JOURNAL

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

(2015) Nilgun I. Reed et al.   Science Translational Medicine

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE