Article
Medicine, General & Internal
Tania H. Bisgaard, Gry Poulsen, Kristine H. Allin, Laurie Keefer, Ashwin N. Ananthakrishnan, Tine Jess
Summary: This population-based study found that inflammatory bowel disease (IBD) is associated with increased risk of anxiety and depression both before and after IBD diagnosis. The risk is particularly high around the time of IBD diagnosis and in patients diagnosed after the age of 40.
Article
Nutrition & Dietetics
Georgiana-Emmanuela Gilca-Blanariu, Anca Trifan, Manuela Ciocoiu, Iolanda Valentina Popa, Alexandru Burlacu, Gheorghe G. Balan, Andrei Vasile Olteanu, Gabriela Stefanescu
Summary: This study found that hair magnesium concentration in IBD patients is significantly lower compared to healthy controls, and is related to disease activity, psychological status, and sleep quality. The findings suggest that magnesium may play a crucial role in IBD pathophysiology, and supplementation could potentially improve disease progression and sleep quality for patients with magnesium deficiency.
Article
Gastroenterology & Hepatology
Birte Klusmann, Joke Fleer, K. Annika Tovote, Rinse K. Weersma, Hendrik M. van Dullemen, Gerard Dijkstra, Maya J. Schroevers
Summary: This study identified distinct trajectories of fatigue among IBD patients, with some showing chronic elevated levels of fatigue associated with greater disease activity and reduced well-being. Reducing disease activity may be important for treating fatigue and improving self-reported well-being.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Charles N. N. Bernstein, John D. D. Fisk, Randy Walld, James M. M. Bolton, Jitender Sareen, Scott B. B. Patten, Alexander Singer, Lisa M. Lix, Carol A. A. Hitchon, Renee El-Gabalawy, Lesley A. A. Graff, Alan Katz, Kelcie Witges, James J. J. Marriott, Ruth Ann Marrie
Summary: The use of benzodiazepines and Z-drugs is higher in patients with inflammatory bowel disease (IBD) compared to controls. Strategies are needed to reduce benzodiazepine use in individuals with IBD and provide alternative management options for mood/anxiety disorders, sleep disorders, and other symptoms.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Laurie Keefer, Alyse Bedell, Christine Norton, Ailsa L. Hart
Summary: Early diagnosis and optimal control of inflammation are best practices for managing inflammatory bowel disease. Patients often experience challenging symptoms, such as abdominal pain, fatigue, depression, and anxiety, that are not properly addressed. This review highlights the burden of these symptoms, suggests assessment methods, and emphasizes the importance of acknowledging and validating patient's symptoms.
Review
Microbiology
Georgiana-Emmanuela Gilca-Blanariu, Cristina Gabriela Schiopu, Gabriela Stefanescu, Catalina Mihai, Smaranda Diaconescu, Vlad Adrian Afrasanie, Vasile Valeriu Lupu, Ancuta Lupu, Alexandra Bolos, Cristinel Stefanescu
Summary: Inflammatory bowel disease has a significant impact on the lives of patients and is closely associated with psychiatric symptoms. The modulation of the gut-brain axis and the role of the gut microbiota play crucial roles in this complex relationship.
Article
Gastroenterology & Hepatology
Keeley M. Fairbrass, David J. Gracie, Alexander C. Ford
Summary: Psychological co-morbidity is more common in patients with inflammatory bowel disease (IBD) and has a cumulative effect on disease behavior, leading to worse disease progression in patients with increasing psychological burden.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Psychiatry
Shihao Duan, Yi Yang, Yubin Cao, Pingrun Chen, Chang Liang, Yan Zhang
Summary: This study aimed to investigate the impact of anxiety and depression on the efficacy of medications and IBD-related poor outcomes in patients with inflammatory bowel disease (IBD). The results showed that anxiety and depression symptoms were significantly associated with steroid resistance and IBD-related poor outcomes. Further studies are needed to explore whether interventions for anxiety and depression can improve medication response and prognosis in IBD patients.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Psychiatry
Shurong Hu, Yiping Chen, Yan Chen, Caihua Wang
Summary: Mental health is an important aspect of care for IBD patients, with anxiety and depression being common psychological conditions. Screening and treating these mental disorders can lead to improved outcomes.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Gastroenterology & Hepatology
Martina Sciberras, Konstantinos Karmiris, Catarina Nascimento, Trevor Tabone, Penelope Nikolaou, Angeliki Theodoropoulou, Abigail Mula, Idan Goren, Henit Yanai, Hadar Amir, Gerassimnos J. Mantzaris, Tereza Georgiadi, Kalliopi Foteinogiannopoulou, Ioannis Koutroubakis, Mariangela Allocca, Gionata Fiorino, Federica Furfaro, Konstantinos Katsanos, Fotios Fousekis, George Michalopoulos, Liberato Camilleri, Joana Torres, Pierre Ellul
Summary: This study assessed the prevalence of depression/anxiety, presenteeism and exercise levels among IBD patients. The results showed that a significant percentage of IBD patients in remission suffer from anxiety and/or depression. Depression/anxiety was associated with a sedentary lifestyle, lower presenteeism at work, and unemployment.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Medicine, General & Internal
M. P. Eugenicos, N. B. Ferreira
Summary: This review examined recent evidence on the impact of depression and anxiety on disease activity, relapse, and healthcare utilization in inflammatory bowel disease (IBD), highlighting the importance of assessing depression and anxiety in routine management of IBD patients. Developing more longitudinal research and randomized controlled trials will provide further insights into the role of mental health in IBD outcomes.
BRITISH MEDICAL BULLETIN
(2021)
Article
Multidisciplinary Sciences
Laura Tasson, Fabiana Zingone, Brigida Barberio, Romina Valentini, Pamela Ballotta, Alexander C. Ford, Marco Scarpa, Imerio Angriman, Matteo Fassan, Edoardo Savarino
Summary: The study found that fatigue is common in IBD patients, and abnormal CRP, sarcopenia, and severe anxiety are factors independently associated with severe fatigue.
SCIENTIFIC REPORTS
(2021)
Review
Gastroenterology & Hepatology
Lexa K. Murphy, Rocio de la Vega, Sara Ahola Kohut, Joy S. Kawamura, Rona L. Levy, Tonya M. Palermo
Summary: The study found that child depression symptoms and pain catastrophizing were associated with pain and pain impact in pediatric IBD, and pain and impact were also related to child anxiety symptoms, pain worry, and parent pain catastrophizing. Female sex and disease severity were significantly associated with pain and pain impact.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Immunology
Li Ge, Shuman Liu, Sha Li, Jing Yang, Guangran Hu, Changqing Xu, Wengang Song
Summary: This review explores the possible link between psychological stress and inflammatory bowel disease (IBD) from a psychoneuroimmunology perspective. It emphasizes the bidirectionality of the brain-gut axis, suggesting that IBD pathophysiology increases central nervous system inflammation and contributes to anxiety and depression-like behavioral comorbidities.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychology, Multidisciplinary
Cornelia Rada, Dan Gheonea, Cristian George Tieranu, Denisa Elena Popa
Summary: Inflammatory bowel disease (IBD) is a chronic and incurable disease that significantly affects patients' quality of life. This study found a relationship between early maladaptive schemas and disease activity status, and a high prevalence of early maladaptive schemas in patients. Psychotherapeutic intervention is needed for these patients.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Gastroenterology & Hepatology
Brigida Barberio, Pierfrancesco Visaggi, Edoardo Savarino, Nicola de Bortoli, Christopher J. Black, Alexander C. Ford
Summary: This study conducted a network meta-analysis to evaluate the efficacy and safety of different medical therapies for endoscopy-negative reflux disease. The results showed that proton pump inhibitors (PPIs) are superior to other drugs in treating this condition. Future research should focus on better patient classification and investigating the efficacy of other drugs.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Vivek C. Goodoory, Cho Ee Ng, Christopher J. Black, Alexander C. Ford
Summary: This study examined willingness to pay for medications among individuals with irritable bowel syndrome (IBS). The results showed that women and individuals with an annual income of 30,000 pounds or more were more likely to be willing to pay for medication. In addition, individuals with lower IBS-related quality of life were more willing to pay for a medication that could improve their symptoms.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Vivek C. C. Goodoory, Elspeth A. A. Guthrie, Cho E. E. Ng, Christopher J. J. Black, Alexander C. C. Ford
Summary: Irritable bowel syndrome (IBS) has a substantial impact on the quality of life of affected individuals, and the negative impact is worse than observed in some severe chronic organic conditions.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Maria Rosa Ingrosso, Michael Camilleri, Jan Tack, Gianluca Ianiro, Christopher J. Black, Alexander C. Ford
Summary: This study evaluated the efficacy and safety of drugs for gastroparesis through a network meta-analysis. The results showed that oral dopamine antagonists and tachykinin-1 antagonists were more effective than placebo. For individual symptoms, oral metoclopramide showed good efficacy for nausea, fullness, and bloating. However, the confidence in the evidence for most comparisons was low to moderate, indicating a need for more effective therapies for gastroparesis.
Article
Gastroenterology & Hepatology
Brigida Barberio, David J. Gracie, Christopher J. Black, Alexander C. Ford
Summary: In this study, the authors conducted a systematic review and meta-analysis to evaluate the impact of criteria used to define CD activity at study entry and the time point used to confirm efficacy on the therapeutic gain of active drug over placebo. The results showed that both factors appeared to be important in maximizing the treatment effect of active drug compared to placebo.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Gastroenterology & Hepatology
Vivek C. Goodoory, Elspeth A. Guthrie, Cho Ee Ng, Christopher J. Black, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Vivek C. Goodoory, Cho E. Ng, Christopher J. Black, Alexander C. Ford
Summary: This study compared the characteristics of individuals with irritable bowel syndrome (IBS) reporting faecal incontinence (FI) with those who do not report FI. The results showed that individuals with FI were older, more likely to have IBS-D, had lower education levels and incomes, reported more urgency and more severe IBS and psychological symptoms, had lower quality of life scores, and higher healthcare costs.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Kee-Huat Chuah, Christopher J. Black, Vincent Tee, Sze-Zee Lim, Wen-Xuan Hian, Nur-Fazimah Sahran, Yeong-Yeh Lee, Sanjiv Mahadeva, Alexander C. Ford
Summary: By comparing IBS patients from the UK and Malaysia, it was found that UK patients were more likely to consume alcohol, had more frequent symptoms such as pain, bloating, and meal-related issues, higher symptom scores, greater limitation of activities, and a higher likelihood of reporting abnormal anxiety. UK patients also had higher levels of perceived stress, gastrointestinal symptom-specific anxiety, and somatoform symptom-reporting.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Vivek C. Goodoory, Cho Ee Ng, Christopher J. Black, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Vivek C. Goodoory, Elspeth A. Guthrie, Cho Ee Ng, Christopher J. Black, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Vivek C. Goodoory, Cho E. Ng, Christopher J. Black, Alexander C. Ford
Summary: This article is associated with Goodoory et al papers. Click the link to access these articles.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Christy Riggott, Keeley M. Fairbrass, Christopher J. Black, David J. Gracie, Alexander C. Ford
Summary: Using latent class analysis, this study identified novel clusters of patients with inflammatory bowel disease (IBD) and found that patients with higher gastrointestinal and psychological symptoms were at a higher risk of adverse disease outcomes and were also high-volume users of healthcare.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Kee-Huat Chuah, Christopher J. Black, Vincent Tee, Sze-Zee Lim, Wen-Xuan Hian, Nur-Fazimah Sahran, Yeong-Yeh Lee, Sanjiv Mahadeva, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Psychiatry
Jess G. Fiedorowicz, Else Guthrie, Bernd Loewe
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Editorial Material
Gastroenterology & Hepatology
Maura Corsetti, Andrea Shin, Christopher Black, Daniel Keszthelyi, Fedias L. Christofi, Frank Zerbib, Kirsteen Browning, Michael Jones
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)