Article
Chemistry, Physical
Lineng Wei, Ziyu Wang, Xiuxin Lu, Jingqi Chen, Yujie Zhai, Qinghua Huang, Shenglin Pei, Yan Liu, Weiqing Zhang
Summary: This study reports the development of a novel nanozyme Ir6.2-Co(OH)2 with remarkable peroxidase and catalase activities, capable of generating reactive oxygen species by supplementing hydrogen peroxide and depleting glutathione. In vitro and in vivo experiments demonstrate that this nanozyme significantly enhances antitumor efficacy through apoptosis-ferroptosis synergistic therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Article
Chemistry, Multidisciplinary
Xiangqin Meng, Dandan Li, Lei Chen, Helen He, Qian Wang, Chaoyi Hong, Jiuyang He, Xingfa Gao, Yili Yang, Bing Jiang, Guohui Nie, Xiyun Yan, Lizeng Gao, Kelong Fan
Summary: The pyrite peroxidase nanozyme demonstrates ultra-high affinity for H2O2 and possesses intrinsic glutathione oxidase-like activity, resulting in abundant production of (OH)-O-center dot and depletion of reduced glutathione, inducing apoptosis and ferroptosis of tumor cells. It shows potential for effective therapeutic application in tumor catalytic therapy.
Article
Chemistry, Multidisciplinary
Haitao Yuan, Peng Xia, Xin Sun, Jingbo Ma, Xiaolong Xu, Chunjin Fu, Hongchao Zhou, Yudong Guan, Zhifen Li, Shanshan Zhao, Huifang Wang, Lingyun Dai, Chengchao Xu, Shaohong Dong, Qingshan Geng, Zhijie Li, Jigang Wang
Summary: This study develops a nanosystem based on the tumor microenvironment to achieve tumor control through simultaneous induction of ferroptosis and apoptosis. The synergistic strategy increases the production of intracellular lipid-reactive oxygen species, leading to complete eradication of tumors.
Article
Nanoscience & Nanotechnology
Jiezhao Zhan, Jianping Liu, Jing Yang, Lin Huang, Yudie Lu, Xuanyi Lu, Jiaoyang Zhu, Sugeun Yang, Zheyu Shen
Summary: This study presents a cascade nanozyme that releases H2S to enhance the production of hydroxyl radicals and promote ferroptosis in tumor cells. The nanozyme shows superior therapeutic effects compared to nanoparticles or nanozymes alone, offering a simple but powerful method for developing tumor therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Jiezhao Zhan, Jianping Liu, Jing Yang, Lin Huang, Yudie Lu, Xuanyi Lu, Jiaoyang Zhu, Sugeun Yang, Zheyu Shen
Summary: In this study, a nanozyme with H2S-releasing ability was designed to enhance the generation of ·OH and achieve effective ferroptosis for tumor therapy by increasing the H2O2 level and acidity in tumor cells through cascade reactions and the biological effects of released H2S. The experimental results demonstrated that this nanozyme showed superior therapeutic effect compared to others.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Shikai Liu, Wenting Li, He Ding, Boshi Tian, Linyang Fang, Xudong Zhao, Ruoxi Zhao, Baichao An, Lianfei Ding, Lei Zhong, Piaoping Yang
Summary: This study designs chlorin e6 (Ce6) and bovine serum albumin-ruthenium dioxide nanozyme (BCNR) for ultrasound-triggered peroxynitrite-mediated ferroptosis. The Ce6 and RuO2 generate highly efficient singlet oxygen (O-1(2)) upon ultrasound stimulation. BCNR releases nitric oxide (NO) on-demand, which reacts with O-1(2) forming highly cytotoxic peroxynitrite (ONOO-). BCNR nanozyme consumes glutathione (GSH) and downregulates glutathione reductase, ensuring complete depletion of GSH within the tumor and enhancing ferroptosis sensitization of cancer cells.
Article
Chemistry, Multidisciplinary
Longwei Wang, Xiaodi Zhang, Zhen You, Zhongwei Yang, Mengyu Guo, Jiawei Guo, He Liu, Xiaoyu Zhang, Zhuo Wang, Aizhu Wang, Yawei Lv, Jian Zhang, Xin Yu, Jing Liu, Chunying Chen
Summary: The deficient catalytic activity of nanozymes and insufficient endogenous H2O2 in the tumor microenvironment (TME) are major obstacles for nanozyme-mediated catalytic tumor therapy. We explored the contributing factors of enzymatic activity based on positive and negative charges, which are experimentally and theoretically demonstrated to enhance the peroxidase (POD)-like activity of a MoS2 nanozyme. Hence, an acidic tumor microenvironment-responsive and ultrasound-mediated cascade nanocatalyst (BTO/MoS2@CA) is presented that enables effective tumor ferroptosis with minimal side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biotechnology & Applied Microbiology
Jianxin Wang, Yinzhu Chu, Zhiyu Zhao, Cong Zhang, Qi Chen, Haitao Ran, Yang Cao, Changjun Wu
Summary: Graphdiyne has potential enzymatic properties. Metal-free sulfur-doped Graphdiyne (S-GDY) is piezoelectric and ultrasonic excitation enhances its peroxidase activity, inducing apoptosis in 4T1 cells. The enhanced nanozyme activity of S-GDY triggers apoptosis-ferroptosis for effective tumor therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mengyu Chang, Zhiyao Hou, Man Wang, Chunzheng Yang, Ruifeng Wang, Fang Li, Donglian Liu, Tieli Peng, Chunxia Li, Jun Lin
Summary: Photothermal therapy (PTT) is a promising tumor therapeutic modality, but minimizing damage to healthy tissues while maximizing efficiency is crucial. Utilizing a single-atom nanozyme (SAzyme) can improve the effectiveness of mild PTT by promoting ferroptosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Meng Lyu, Min Luo, Jingyun Li, Ozioma Udochukwu Akakuru, Xiaowan Fan, Zhen Cao, Kelong Fan, Wei Jiang
Summary: This study reports a multipathway ferroptosis-enhanced radioimmunotherapeutic strategy that combines single-atom nanozyme (SAzyme)-based GSH depletion and CO gas therapy for personalized FLASH radioimmunotherapy. The carbon monoxide donor (MnCO)-loaded porous Pd-C SAzyme (SM) is encapsulated within 4T1 cancer cell membranes (CSM) to achieve targeted delivery. The CSM-mediated FLASH radioimmunotherapy induces ferroptosis, enhances antitumor immunity, and inhibits tumor recurrence.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Oncology
Yunpeng Huang, Xiaoyu Li, Zijian Zhang, Li Xiong, Yongxiang Wang, Yu Wen
Summary: This study focused on the synergistic antitumor effects of photodynamic therapy (PDT) and ferroptosis. The application of nanomaterials and drug combination in PDT combined with ferroptosis were explored. Nanomaterials can activate anti-tumor immunity, improve the hypoxic microenvironment, and inhibit tumor angiogenesis to exert synergistic effects. However, there are still shortcomings in current combination treatment strategies that need to be addressed.
Article
Agriculture, Multidisciplinary
Junmin Xi, Li-Li Tian, Jiahui Xi, Desire Girimpuhwe, Chongfei Huang, Ruixia Ma, Xiaojun Yao, Danfeng Shi, Zhongtian Bai, Quan-Xiang Wu, Jianguo Fang
Summary: This study isolated and characterized two compounds from an endophytic fungus and investigated the antitumor mechanism of one compound AP. The study found that AP inhibits the growth of liver cancer cells by targeting the selenoprotein thioredoxin reductase (TrxR) and ultimately induces cell apoptosis and ferroptosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jia Zeng, Yufeng Wang, Jingpeng Wu, Huiwen Wang, Junrong Lu, Shijie Li, Dongfeng He
Summary: This study presents a multi-modality oncotherapy method using a metallic Ni0.5Fe0.5S2 nanosphere for synergetic chemodynamic/photodynamic/photothermal antitumor treatments. Under NIR excitation, Ni0.5Fe0.5S2 generates a significant photothermal effect for photothermal therapy. It also triggers the formation of reactive oxygen species (ROS) and catalyzes the conversion of H2O2, achieving photodynamic and chemodynamic therapy. The synergistic effects result in a better antitumor outcome compared to single treatment methods, allowing for complete removal of solid tumors at a lower temperature.
Article
Biochemistry & Molecular Biology
Ye Zhong, Zhi-Ning Li, Xin-Yue Jiang, Xing Tian, Ming-Hui Deng, Mao-Sheng Cheng, Hua-Li Yang, Yang Liu
Summary: A series of novel 1,3,4-oxadiazole-artemisinin hybrids have been designed and synthesized, among which A8 showed superior anti-proliferative activities against cancer cells. Further mechanism studies revealed that A8 induces apoptosis and ferroptosis in cells, and exhibits moderate inhibitory effects on CYP enzymes in the human body.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Yutian Xia, Jianzhong Zhang, Gang Liu
Summary: Apoptosis, as a fundamental process of cell death, has provided broad prospects for tumor treatment in nanomedicine. However, apoptosis resistance caused by various factors has led to therapeutic failure or tumor recurrence. Ferroptosis, a newly identified form of programmed cell death, offers a new approach to killing cancer cells beyond apoptosis. Combination therapy, which synergizes ferroptosis with apoptosis, has shown promising results in clinical applications. This review summarizes the latest research progress in combining ferroptosis with apoptosis for enhanced tumor therapeutic effects in nanomedicine and suggests a potential research focus for the future.
Article
Gastroenterology & Hepatology
Xin Gao, Qiugui Bian, Wenqin Ding, Haisheng Qian, Wenjie Li, Guoxin Zhang, Xuan Li
Summary: This study aimed to explore the effectiveness of walking exercise and intestinal cleansing interval in bowel preparation before colonoscopy. The results showed that taking 10,000 steps of walking exercise during the intestinal preparation and taking polyethylene glycol (PEG) 5.12 hours prior to the procedure were effective in cleaning the colon and improving the accuracy of colonoscopy.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Engineering, Biomedical
Dongdong Liu, Xingliang Dai, Wei Zhang, Xuyang Zhu, Zhengbao Zha, Haisheng Qian, Liang Cheng, Xianwen Wang
Summary: Liquid exfoliation was used to create ultrasmall zirconium carbide nanodots (NDs) as noninflammatory/anti-inflammatory photosensitizers for photothermal therapy (PTT) of glioma. The ultrasmall ZrC NDs showed excellent photothermal stability and biocompatibility, effectively ablating glioma at low concentrations and inhibiting tumor migration and proliferation. Furthermore, the ultrasmall ZrC NDs suppressed the inflammatory response to PTT by exhibiting excellent ROS-scavenging ability.
Article
Gastroenterology & Hepatology
Haisheng Qian, Yanjuan Wang, Xiaosu Chen, Lin Lin, Weifeng Zhang, Yun Wang, Nana Tang, Xinmin Si, Chunhua Jiao, Guoxin Zhang, Bixing Ye
Summary: This study preliminarily explored the association between muscularis macrophages (MM phi) and achalasia. The findings showed that patients with achalasia had fewer interstitial cells of Cajal (ICC) and higher levels of M1 macrophages in the lower esophageal sphincter (LES). There were significant correlations between M2/MM phi and the numbers of ICC and glial cells, suggesting that MM phi may be associated with the occurrence and development of achalasia.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Chemistry, Physical
Weiqing Zhang, Xuhui Qin, Tianran Wei, Qian Liu, Jun Luo, Xijun Liu
Summary: A high-performance catalyst made of single atomic Ce sites anchored on nitrogen-doped hollow carbon spheres has been developed. It can efficiently electrocatalyze the reduction of NO to NH3 in an acidic solution, achieving a maximal Faradaic efficiency of 91% and a yield rate of 1023 lg h-1 mgcat.-1. The catalyst outperforms Ce nanoclusters and shows good structural and electrochemical stability.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Xiuxin Lu, Kun Qiao, Firdoz Shaik, Yang Zheng, Zhaoyou Chu, Haisheng Qian, Xijun Liu, Weiqing Zhang
Summary: Facilitated by ROS-involved therapies, tumor cells undergo ICD to stimulate long-term immunity response. However, it is challenging to trigger abundant and large-scale ICD for effective cancer immunotherapy. In this study, a multifunctional sonosensitizer (Au-S/C-TiO2) is developed, which enhances SDT and glucose depletion, leading to robust ICD through increased ROS generation and strong ER stress. The synergy effect between Au cluster/single atom with TiO2 nanosheets intensifies apoptosis and ICD pathways to inhibit 80% of tumor cells. In vivo analyses demonstrate the effectiveness of Au-S/C-TiO2 in inducing antitumor immunity.
Article
Engineering, Biomedical
Juan Yang, Zhaoyou Chu, Yechun Jiang, Wang Zheng, Jiangwei Sun, Lingling Xu, Yan Ma, Wanni Wang, Min Shao, Haisheng Qian
Summary: A multicomponent enzyme-responsive natural polymer embedded in a cerium/zinc-based nanomaterial is reported for the treatment of nonhealing diabetic wounds. The material can destroy bacterial oxidation balance, kill bacteria, and alleviate oxidative stress. Furthermore, it exhibits anti-inflammatory activity and promotes cell proliferation, migration, and angiogenesis. In vivo studies show that the microneedle accelerates wound healing without systemic toxicity.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Zetong Chen, Zhaoyou Chu, Yechun Jiang, Lingling Xu, Haisheng Qian, Yuanyin Wang, Wanni Wang
Summary: An imbalance of bacteria in the oral environment can lead to various oral diseases. Finding suitable alternatives to traditional antibacterial methods is crucial due to increasing bacterial resistance. Antibacterial agents based on nanomaterials have attracted attention in the dental field for their low cost, stable structures, excellent antibacterial properties, and broad spectrum. Multifunctional nanomaterials have made significant progress in the long-term prevention and treatment of oral diseases by inactivating oral bacteria and improving material properties.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Physical
Bin Jiang, Yuchen Tian, Yang An, Rong Liu, Firdoz Shaik
Summary: In this study, a catalyst composed of heteroatom-doped carbon quantum dots loaded on vertical graphene was designed using density functional theory for the hydrogen evolution reaction. The experimental results confirmed that the heteroatoms played a crucial role in the catalyst's activity, with the N-doped catalyst exhibiting the best performance.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Electrochemistry
Yun Kong, Kaiming Guo, Rong Liu, Banrui Yan, Firdoz Shaik, Bin Jiang
Summary: In this study, a novel electrocatalyst Fe, Ni-Co5.47N@N-rGO consisting of Fe/Ni-doped Co5.47N nanoparticles and N-doped vertically reduced graphene oxide arrays (N-VrGO) was reported for overall water splitting. The synergistic effect of N in N-VrGO and N in Fe, Ni-Co5.47N promotes the electron rearrangement on the metal surface and further enhances the electrocatalytic performance of the catalyst. The Fe, Ni-Co5.47N@N-VrGO-2 catalyst exhibits lower overpotentials for hydrogen evolution and oxygen evolution reactions, as well as a good Faraday efficiency and outstanding stability.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Xiaowei Song, Haisheng Qian, Yongqiang Yu
Summary: This article reviews the application and progress of nanomedicine delivery systems in brain tumors, summarizing the mechanism of nanomaterials crossing the blood-brain barrier and discussing the specific application of nanotechnology in glioblastoma.
Article
Chemistry, Multidisciplinary
Liang Xiao, Benjin Chen, Wanni Wang, Tian Tian, Haisheng Qian, Xiaohu Li, Yongqiang Yu
Summary: Au@AgBiS2 nanoparticles, with a core-shell structure of metal-semiconductors, can enhance DNA damage and ROS production in radiotherapy, resulting in improved therapeutic effects. Moreover, these nanoparticles induce pyroptosis and activate the anti-tumor immune response against breast cancer and metastasis.
Article
Environmental Sciences
Wenjie Li, Xingzhou Jiang, Haisheng Qian, Xinyan Li, Jing Su, Guoxin Zhang, Xuan Li
Summary: This study aimed to investigate the relationship between arsenic exposure and liver injury in adults. Using data from the NHANES, urinary arsenic concentrations were measured and markers of liver injury were analyzed. The results showed a positive association between urinary arsenic exposure and liver injury in adults, and sex and smokers may play a role in arsenic pathogenicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Physical
Lineng Wei, Ziyu Wang, Xiuxin Lu, Jingqi Chen, Yujie Zhai, Qinghua Huang, Shenglin Pei, Yan Liu, Weiqing Zhang
Summary: This study reports the development of a novel nanozyme Ir6.2-Co(OH)2 with remarkable peroxidase and catalase activities, capable of generating reactive oxygen species by supplementing hydrogen peroxide and depleting glutathione. In vitro and in vivo experiments demonstrate that this nanozyme significantly enhances antitumor efficacy through apoptosis-ferroptosis synergistic therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)