Article
Medicine, General & Internal
Urs Fischer, Masatoshi Koga, Daniel Strbian, Mattia Branca, Stefanie Abend, Sven Trelle, Maurizio Paciaroni, Goetz Thomalla, Patrik Michel, Krassen Nedeltchev, Leo H. Bonati, George Ntaios, Thomas Gattringer, Else-Charlotte Sandset, Peter Kelly, Robin Lemmens, P. N. Sylaja, Diana Aguiar de Sousa, Natan M. Bornstein, Zuzana Gdovinova, Takeshi Yoshimoto, Marjaana Tiainen, Helen Thomas, Manju Krishnan, Gek C. Shim, Christoph Gumbinger, Jochen Vehoff, Liqun Zhang, Kosuke Matsuzono, Espen Kristoffersen, Philippe Desfontaines, Peter Vanacker, Angelika Alonso, Yusuke Yakushiji, Caterina Kulyk, Dimitri Hemelsoet, Sven Poli, Ana Paiva Nunes, Nicoletta Caracciolo, Peter Slade, Jelle Demeestere, Alexander Salerno, Markus Kneihsl, Timo Kahles, Daria Giudici, Kanta Tanaka, Silja Raty, Rea Hidalgo, David J. Werring, Martina Goldlin, Marcel Arnold, Cecilia Ferrari, Seraina Beyeler, Christian Fung, Bruno J. Weder, Turgut Tatlisumak, Sabine Fenzl, Beata Rezny-Kasprzak, Arsany Hakim, Georgia Salanti, Claudio Bassetti, Jan Gralla, David J. Seiffge, Thomas Horvath, Jesse Dawson
Summary: This study aimed to compare the effect of early initiation versus later initiation of direct oral anticoagulants (DOACs) on acute ischemic stroke in patients with atrial fibrillation. The results showed that there was no significant difference in the incidence of recurrent ischemic stroke, systemic embolism, major extracranial bleeding, symptomatic intracranial hemorrhage, or vascular death within 30 days between early and later use of DOACs.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Clinical Neurology
Anas Alrohimi, Brian Buck, Glen Jickling, Ashfaq Shuaib, Sibi Thirunavukkarasu, Ken S. Butcher
Summary: This study aimed to assess the impact of early anticoagulation on hemorrhagic transformation in atrial fibrillation (AF) patients after stroke. The results showed that early apixaban treatment did not lead to symptomatic HT, with all HT being asymptomatic on imaging. Recurrent ischemic events were common and clinically symptomatic.
JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Pawel Wankowicz, Przemyslaw Nowacki, Monika Golab-Janowska
Summary: The study found that compared to patients without AF, patients with nonvalvular atrial fibrillation (NVAF) and ischemic stroke (IS) had a higher proportion of smokers, hypertension, history of previous stroke, dyslipidemia, coronary heart disease, more female patients, higher incidence of diabetes mellitus, and older patients. This suggests a need for thorough monitoring of post-ischemic stroke patients with other risk factors that could lead to AF development.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Sean D. Pokorney, Glenn M. Chertow, Hussein R. Al-Khalidi, Dianne Gallup, Pat Dignacco, Kurt Mussina, Nisha Bansal, Crystal A. Gadegbeku, David A. Garcia, Samira Garonzik, Renato D. Lopes, Kenneth W. Mahaffey, Kelly Matsuda, John P. Middleton, Jennifer A. Rymer, George H. Sands, Ravi Thadhani, Kevin L. Thomas, Jeffrey B. Washam, Wolfgang C. Winkelmayer, Christopher B. Granger
Summary: This study evaluated the safety and efficacy of apixaban for stroke prevention in patients with end-stage kidney disease on hemodialysis and atrial fibrillation. The trial showed no significant difference in major or clinically relevant nonmajor bleeding between apixaban and warfarin, and there was overlap in apixaban blood concentration between patients with and without bleeding events. Future randomized studies are needed to assess the risks and benefits of anticoagulation in this population.
Article
Medicine, General & Internal
Pawel Wankowicz, Jacek Staszewski, Aleksander Debiec, Marta Nowakowska-Kotas, Aleksandra Szylinska, Iwona Rotter
Summary: For the prevention of ischemic stroke in atrial fibrillation patients, the most commonly used therapeutic option is oral anticoagulants, with new-generation oral anticoagulants being as effective as old-generation ones but with reduced risk of hemorrhage. However, solely relying on these medications may not be sufficient to protect this group of patients from the risk of ischemic stroke.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Liqi Shu, Wei Jiang, Han Xiao, Nils Henninger, Thanh N. Nguyen, James E. Siegler, Adam de Havenon, Eric D. Goldstein, Daniel Mandel, Maheen Rana, Fawaz Al-Mufti, Jennifer Frontera, Karen Furie, Shadi Yaghi
Summary: This study aimed to determine the risk factors of acute ischemic stroke (AIS) during the periprocedural period in patients with atrial fibrillation (AF). The results showed that higher CHA(2)DS(2)VASc scores, cardiovascular surgery, neurological surgery, and active cancer were associated with an increased risk of periprocedural AIS.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Bum Joon Kim, Yang-Ha Hwang, Man-Seok Park, Joon-Tae Kim, Kang-Ho Choi, Jin-Man Jung, Sungwook Yu, Chi Kyung Kim, Kyungmi Oh, Tae-Jin Song, Yong-Jae Kim, Kwang-Yeol Park, Jeong-Min Kim, Jong-Ho Park, Jay Chol Choi, Jong-Won Chung, Oh Young Bang, Gyeong-Moon Kim, Sung Hyuk Heo, Woo-Keun Seo
Summary: Persistent AF is more associated with AF-related stroke recurrence, while paroxysmal AF is more associated with AF-unrelated stroke recurrence. A scattered lesion in a single vascular territory may predict AF-unrelated stroke recurrence.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Thomas Jensen, Kevin Kris Warnakula Olesen, Raffaele De Caterina, Morten Wurtz, Steen Dalby Kristensen, Michael Maeng
Summary: In patients with atrial fibrillation, diabetes mellitus increases the risk of ischemic stroke regardless of treatment. Both insulin-treated and noninsulin-treated diabetes patients have higher risks of ischemic stroke compared to non-diabetes patients. There is no significant difference in risk between insulin-treated and noninsulin-treated diabetes patients.
VASCULAR PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander P. Benz, Stefan H. Hohnloser, John W. Eikelboom, Anthony P. Carnicelli, Robert P. Giugliano, Christopher B. Granger, Josephine Harrington, Ziad Hijazi, David A. Morrow, Manesh R. Patel, David J. Seiffge, Ashkan Shoamanesh, Lars Wallentin, Qilong Yi, Stuart J. Connolly
Summary: This study aimed to investigate the prognosis of patients with atrial fibrillation (AF) and ischemic stroke while on oral anticoagulation. The results showed that among the 1163 patients who had a post-randomization ischemic stroke while on study medication, 7.0% had a recurrent ischemic stroke within 1 year, and the all-cause mortality rate within 3 months was 12.4%.
EUROPEAN HEART JOURNAL
(2023)
Article
Urology & Nephrology
Yeunmi Kang, Hyung Yun Choi, Young Eun Kwon, Ji Hyeon Shin, Eun Mi Won, Ki Hwa Yang, Hyung Jung Oh, Dong-Ryeol Ryu
Summary: Among Korean dialysis patients, atrial fibrillation (AF) is a significant risk factor for various outcomes, including all-cause mortality, hospitalization, and stroke events. The use of warfarin is associated with an increased risk of hemorrhagic stroke, but not with other outcomes such as all-cause mortality, hospitalization, and ischemic stroke.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Clinical Neurology
Thomas R. Meinel, Mattia Branca, Gian Marco De Marchis, Krassen Nedeltchev, Timo Kahles, Leo Bonati, Marcel Arnold, Mirjam R. Heldner, Simon Jung, Emmanuel Carrera, Elisabeth Dirren, Patrik Michel, Davide Strambo, Carlo W. Cereda, Giovanni Bianco, Georg Kagi, Jochen Vehoff, Mira Katan, Manuel Bolognese, Roland Backhaus, Stephan Salmen, Sylvan Albert, Friedrich Medlin, Christian Berger, Ludwig Schelosky, Susanne Renaud, Julien Niederhauser, Christophe Bonvin, Michael Schaerer, Marie-Luise Mono, Biljana Rodic, Alexander A. Tarnutzer, Pasquale Mordasini, Jan Gralla, Johannes Kaesmacher, Stefan Engelter, Urs Fischer, David J. Seiffge
Summary: In patients with atrial fibrillation, prior treatment with direct oral anticoagulants (DOACs) may be associated with lower stroke severity at onset and lower rates of intravenous thrombolysis, leading to better functional outcomes at 3 months.
ANNALS OF NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Allan Bohm, Peter Snopek, Lubomira Tothova, Branislav Bezak, Nikola Jajcay, Marianna Vachalcova, Tomas Uher, Marian Kurecko, Viera Kissova, Katarina Danova, Peter Olejnik, Peter Michalek, Tereza Hlavata, Katarina Petrikova, Viliam Mojto, Jan Kyselovic, Stefan Farsky
Summary: In patients with high risk of stroke, apelin may be a useful indicator for diagnosing AF and help in preventing stroke occurrence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Clinical Neurology
Peter Bronnum Nielsen, Line Melgaard, Thure Filskov Overvad, Martin Jensen, Torben Bjerregaard Larsen, Gregory Y. H. Lip
Summary: The study found that patients with ICH and AF have a high risk of cerebrovascular ischemic events and a very high risk of all-cause death one year after the incident. Further clinical trials are needed to determine the optimal stroke prevention treatment for ICH survivors with AF.
Article
Multidisciplinary Sciences
You-Jung Choi, Bongseong Kim, Tae-Min Rhee, Hyun-Jung Lee, Heesun Lee, Jun-Bean Park, Seung-Pyo Lee, Kyung-Do Han, Yong-Jin Kim, Hyung-Kwan Kim
Summary: Although atrial fibrillation is a well-known risk factor for ischemic stroke in hypertrophic cardiomyopathy, the risk of stroke in HCM patients without documented AF is not widely recognized. This study found that HCM patients without documented AF have a higher risk of ischemic stroke, especially in those aged 65 and above or with chronic heart failure.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Hui-Tzu Yu, Kuan-Hsuan Chen, Chun-Jen Lin, Chia-Chen Hsu, Yuh-Lih Chang
Summary: This study evaluated the association between the timing of using direct oral anticoagulants (DOACs) after ischemic stroke (IS) and their effectiveness and safety. The findings suggest that there is no significant association between the timing of DOAC initiation and ischemic or hemorrhagic outcomes.
