Characterization of a hepatitis C virus-like particle vaccine produced in a human hepatocyte-derived cell line

Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses

(2014) William O. Osburn et al.   HEPATOLOGY

Apolipoprotein E Likely Contributes to a Maturation Step of Infectious Hepatitis C Virus Particles and Interacts with Viral Envelope Glycoproteins

(2014) J.-Y. Lee et al.   JOURNAL OF VIROLOGY

Recombinant Hepatitis C Virus Envelope Glycoprotein Vaccine Elicits Antibodies Targeting Multiple Epitopes on the Envelope Glycoproteins Associated with Broad Cross-Neutralization

(2014) J. A. J.-X. Wong et al.   JOURNAL OF VIROLOGY

Broadly neutralizing antibodies abrogate established hepatitis C virus infection

(2014) Y. P. de Jong et al.   Science Translational Medicine

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory

(2014) L. Swadling et al.   Science Translational Medicine

A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in Humans

(2013) John Lok Man Law et al.   PLoS One

High Rates of Hepatitis C Virus Reinfection and Spontaneous Clearance of Reinfection in People Who Inject Drugs: A Prospective Cohort Study

(2013) Rachel Sacks-Davis et al.   PLoS One

Ultrastructural analysis of hepatitis C virus particles

(2013) Maria Teresa Catanese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chimeric hepatitis B virus/hepatitis C virus envelope proteins elicit broadly neutralizing antibodies and constitute a potential bivalent prophylactic vaccine

(2012) Elodie Beaumont et al.   HEPATOLOGY

Spontaneous Clearance of Chronic Hepatitis C Virus Infection Is Associated With Appearance of Neutralizing Antibodies and Reversal of T-Cell Exhaustion

(2012) Sukanya Raghuraman et al.   JOURNAL OF INFECTIOUS DISEASES

Hepatitis C virus clearance, reinfection, and persistence, with insights from studies of injecting drug users: towards a vaccine

(2012) Jason Grebely et al.   LANCET INFECTIOUS DISEASES

Hepatitis C VLPs Delivered to Dendritic Cells by a TLR2 Targeting Lipopeptide Results in Enhanced Antibody and Cell-Mediated Responses

(2012) Brendon Y. Chua et al.   PLoS One

Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

(2012) E. Giang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man

(2012) E. Barnes et al.   Science Translational Medicine

In vivoevaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

(2011) Philip Meuleman et al.   HEPATOLOGY

Mapping a Region of Hepatitis C Virus E2 That Is Responsible for Escape from Neutralizing Antibodies and a Core CD81-Binding Region That Does Not Tolerate Neutralization Escape Mutations

(2011) Z.-Y. Keck et al.   JOURNAL OF VIROLOGY

A genetically humanized mouse model for hepatitis C virus infection

(2011) Marcus Dorner et al.   NATURE

A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques

(2011) P. Garrone et al.   Science Translational Medicine

Meta-Analysis of Hepatitis C Virus Vaccine Efficacy in Chimpanzees Indicates an Importance for Structural Proteins

(2010) Harel Dahari et al.   GASTROENTEROLOGY

Ultrastructural and Biophysical Characterization of Hepatitis C Virus Particles Produced in Cell Culture

(2010) P. Gastaminza et al.   JOURNAL OF VIROLOGY

Characterization of the Envelope Glycoproteins Associated with Infectious Hepatitis C Virus

(2010) G. Vieyres et al.   JOURNAL OF VIROLOGY

Assembly of infectious hepatitis C virus particles

(2010) Ralf Bartenschlager et al.   TRENDS IN MICROBIOLOGY

Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults

(2010) Sharon E. Frey et al.   VACCINE

The Disulfide Bonds in Glycoprotein E2 of Hepatitis C Virus Reveal the Tertiary Organization of the Molecule

(2010) Thomas Krey et al.   PLoS Pathogens

Selection Pressure From Neutralizing Antibodies Drives Sequence Evolution During Acute Infection With Hepatitis C Virus

(2009) Kimberly A. Dowd et al.   GASTROENTEROLOGY

Identification and Characterization of Broadly Neutralizing Human Monoclonal Antibodies Directed against the E2 Envelope Glycoprotein of Hepatitis C Virus

(2009) T. J. Broering et al.   JOURNAL OF VIROLOGY

Chimeric hepatitis B and C viruses envelope proteins can form subviral particles: implications for the design of new vaccine strategies

(2009) Romuald Patient et al.   New Biotechnology

Hepatitis C Virus (HCV) Infection May Elicit Neutralizing Antibodies Targeting Epitopes Conserved in All Viral Genotypes

(2009) Nicasio Mancini et al.   PLoS One

A single point mutation in E2 enhances hepatitis C virus infectivity and alters lipoprotein association of viral particles

(2009) Wanyin Tao et al.   VIROLOGY

Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver–chimeric mice from infection with a homologous hepatitis C virus strain

(2008) Thomas Vanwolleghem et al.   HEPATOLOGY

Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein

(2008) A. M. Owsianka et al.   JOURNAL OF GENERAL VIROLOGY

Apolipoprotein C1 Association with Hepatitis C Virus

(2008) J.-C. Meunier et al.   JOURNAL OF VIROLOGY

Definition of a Conserved Immunodominant Domain on Hepatitis C Virus E2 Glycoprotein by Neutralizing Human Monoclonal Antibodies

(2008) Z.-Y. Keck et al.   JOURNAL OF VIROLOGY

A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infection

(2008) Brendon Y. Chua et al.   VACCINE