Article
Nutrition & Dietetics
Rui Liu, Na Zhu, Yuntao Hao, Xinran Liu, Jiawei Kang, Ruixue Mao, Xiaochen Yu, Yong Li
Summary: The study aimed to investigate the protective effects of walnut oligopeptides on indomethacin-induced gastric ulcers in rats. The results showed that walnut oligopeptides had a significant gastroprotective effect by regulating inflammatory cytokines, oxidative stress, prostaglandins synthesis, and enhancing the expression of COX-1 and COX-2 in gastric tissue. The gastroprotective mechanism may be related to arachidonic acid metabolism and upregulation of tryptophan, phenylalanine, tyrosine, and alpha-Linolenic acid metabolism synthesis in vivo.
Article
Biochemistry & Molecular Biology
Bowei Zhang, Xiaoxiao Rao, Yunhui Zhang, Weijia Dai, Yingchuan Xu, Congying Zhao, Zhenjia Chen, Jin Wang, Dancai Fan, Xiaowen Wang, Shuo Wang
Summary: This study confirmed the gastroprotective effect of foxtail millet protein hydrolysate and revealed that its mechanism of action is through regulating gastric mucosal mucus and nitric oxide synthesis. This provides a basis for using foxtail millet protein as a functional food to improve gastric ulcers and related oxidative stress.
Article
Biochemistry & Molecular Biology
Liangzi Sun, Mengqi Li, Shuyu Zhang, Zhijie Bao, Songyi Lin
Summary: This study focused on the mechanism of Ser-Ala-Gly-Pro-Ala-Phe (SAGPAF) treatment to improve gastric mucosal injury in mice. The findings showed that PEF-treated SAGPAF enhanced the gastric mucosal barrier function by inhibiting the activation of the MAPK and NF-κB signaling pathways, reducing the ethanol-induced inflammatory response and oxidative stress.
Article
Plant Sciences
Guanru Chen, Xiaofang Xie, Fu Peng, Tianzhixin Wang, Junren Chen, Gangmin Li, Juan Liu, Cheng Peng
Summary: The combination of essential oils from patchouli and tangerine peel can repair gastric mucosal damage in GU rats, prevent ulcer occurrence by inhibiting gastric acid secretion, enhancing gastric mucosal defensive ability, and suppressing gastric epithelial cell apoptosis. The optimal compatible ratio of patchouli and tangerine peel is 1:2.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Kaiwen Lin, Tang Deng, Huijuan Qu, Hongya Ou, Qifeng Huang, Bingmiao Gao, Xiaoliang Li, Na Wei
Summary: This study investigated the protective mechanism of total flavonoid of Alpinia officinarum Hance (FAOH) on acetic acid-induced chronic gastric ulcers (GU) in rats and ethanol-induced GES-1 cell damage. The results showed that FAOH reduced the area of gastric ulcers, reversed cell apoptosis, and decreased inflammation and oxidative stress.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Antonella Brizzi, Samuele Maramai, Francesca Aiello, Maria Camilla Baratto, Federico Corelli, Claudia Mugnaini, Marco Paolino, Francesco Scorzelli, Carlo Aldinucci, Luciano De Petrocellis, Cinzia Signorini, Federica Pessina
Summary: The study suggests that lipoic amides can act as TRPV1 agonists and possess antioxidant properties, potentially protecting against hypoxia damage and reducing oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Mydhili Govindarasu, Mohammad Azam Ansari, Mohammad N. Alomary, Sami AlYahya, Saad Alghamdi, Azzah M. Bannunah, Mazen Almehmadi, Pari Abirami, Ekambaram Gayathiri, Mariyappan Palani, Govindasamy Rajakumar, Muthu Thiruvengadam, Manju Vaiyapuri
Summary: Experimental studies have shown that Salvianolic acid B (Sal B) displays anti-ulcer effects in a mouse model of colitis triggered by acetic acid, indicating its therapeutic potential for ulcerative colitis.
Review
Anatomy & Morphology
Ilknur Birsen, V. Nimet Izgut-Uysal
Summary: The apelin/APJ system plays a vital role in regulating physiological and pathophysiological mechanisms as well as protecting the gastric mucosa from harmful effects in the digestive system.
Article
Nutrition & Dietetics
Minhee Lee, Dakyung Kim, Hyunji Kim, Sukyung Jo, Ok-Kyung Kim, Jeongmin Lee
Summary: The study demonstrated that Glycine max (L.) Merr. fermented using Lactobacillus delbrueckii ssp. delbrueckii Rosell-187 (Gastro-AD (R)) can alleviate ethanol/HCl-induced gastric damage, with gastro-protective effects such as reducing gastric acid secretion, increasing prostaglandin E2 levels, and decreasing inflammatory factors levels.
Article
Pharmacology & Pharmacy
Jiawei Liu, Jiahui Fang, Junxiong Zhang, Dan Wang, Zhihong Zhang, Chunmei Wang, Jinghui Sun, Jianguang Chen, He Li, Shu Jing
Summary: Anwulignan (AN) has a significant protective effect against indomethacin-induced gastric injury in mice, which may be attributed to its activation of Nrf2, inhibition of NF-KB signaling pathway, and anti-apoptotic effect.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Huseyin Sahin, Kaan Kaltalioglu, Zuleyha Erisgin, Sule Coskun-Cevher, Sevgi Kolayli
Summary: This study examined the protective effects of different propolis extracts on gastric mucosa in indomethacin-induced rats. The results showed that the aqueous-based propolis extracts at doses of 200 and 400 mg/kg had the most positive effects on the gastric mucosa. Biochemical analysis and phenolic profile analysis supported these findings. The ethanolic extract had higher total phenolic content, total flavonoid content, and DPPH radical scavenging activity compared to the aqueous-based extracts.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Ana Carolina Mendes Hacke, Taynara Pacheco Valerio, Mateus Florido Cubo, Dhesmon Lima, Christiana Andrade Pessoa, Jose Carlos Rebuglio Vellosa, Romaiana Picada Pereira
Summary: This study aimed to investigate the antioxidant activity of extracts obtained from jabuticaba seeds. The results demonstrated that these extracts exhibit remarkable antioxidant power against different reactive oxygen species. Therefore, jabuticaba seeds can be used as by-products for the development of products that protect the human body against diseases related to oxidative stress.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Yuli Shang, Shiyu Yao, Xinrui Qiao, Zhe Wang, Xue Zhao, Zhaohui Huang, Qisheng Gu, Nanping Wang, Cheng Peng
Summary: The study evaluated the effect of Marine Collagen Peptides (MCPs) on oral ulcer healing process, finding that MCPs can accelerate healing by reducing inflammatory cell infiltration, promoting collagenesis, angiogenesis, and re-epithelialization, as well as down-regulating the expressions of IL-1 beta and TNF-alpha. This suggests that MCPs have potential for clinical applications in oral ulcer treatments.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Food Science & Technology
Jian Ren, Sijin Li, Chunli Song, Xiaohong Sun, Xiaolan Liu
Summary: This study demonstrated the protective potential of Alcalase-black soybean-derived peptides (BSPs) against alcohol-induced liver injury in mice, possibly attributed to the antioxidant and anti-inflammatory activities of BSPs.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Environmental Sciences
Setare Jalali, Mehdi Ardjmand, Bahman Ramavandi, Ferial Nosratinia
Summary: This study successfully utilized zeolite Y-sea salt catalyst to remove amoxicillin (AMX) from wastewater, achieving a maximum removal rate of 93% after optimizing parameters. The catalyst showed good stability after AMX removal and was suitable for repeated reuse.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)