Review
Chemistry, Analytical
Peiliang Shen, Yuanyuan Jia, Silin Shi, Jia Sun, Xin Han
Summary: Traditional Chinese medicine (TCM) plays a significant role in disease prevention and treatment, but there are unresolved issues regarding active compounds and mechanisms of action. Therefore, innovative strategies and advanced technologies are promising for TCM research. Microfluidic chips provide controllable platforms for TCM research, enabling analysis and biomedical applications in quality control, delivery, pharmacological activity evaluation, and disease diagnosis of Chinese herbal medicines (CHMs).
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yujia Tu, Linnan Li, Zhengtao Wang, Li Yang
Summary: Traditional Chinese medicine injections (TCMIs) are a new form of pharmaceuticals in the modernization of traditional Chinese medicines, with rapid efficacy and improved curative effects. Chemical and biological analysis methods are widely used in the quality control of TCMIs, with emerging techniques being introduced for better control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Clinical Neurology
Song Li, Zhengzhi Wu, Weidong Le
Summary: In Western medicine, dementia affects cognition, mental health, and physical abilities, while Traditional Chinese Medicine explains it from the perspectives of brain dystrophy, Spleen-Kidney weakness, Blood stasis, and Phlegm stagnation. Ancient Chinese physicians believed that dementia manifests not only as cognitive symptoms but also as psychiatric disorders and sleep disturbance, offering various treatment methods.
ALZHEIMERS & DEMENTIA
(2021)
Article
Integrative & Complementary Medicine
Rui-jin Qiu, Min Li, Jia-yuan Hu, Jing Chen, Hong-cai Shang
Summary: Clinical trial outcome reporting varies between studies combining traditional Chinese medicine and Western medicine, leading to some studies being ineligible for systematic review inclusion and potentially reducing their impact. Developing core outcome sets (COSs) for integrative medicine may help standardize reporting and reduce publication bias in the future.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Review
Pharmacology & Pharmacy
Lei Li, Man Wang, Jikuai Chen, Juelin Chen, Yawei Wang, Minghao Zhao, Qing Song, Shuogui Xu
Summary: As global warming continues, heat waves are becoming more frequent and intense, leading to an increase in the incidence of heat stroke. Heat stroke is associated with significant morbidity and mortality, and further research is urgently needed to address this issue. Traditional Chinese medicine offers potential treatment methods, including herbal therapies and external treatments, which may provide clinical benefits and research directions for heat stroke.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Daqin Chen, Qiannan Li, Huimin Zhang, Fang Kou, Qiang Li, Chunming Lyu, Hai Wei
Summary: Hypertrophic scar is a common pathological response after skin injury that can cause discomfort and affect physical and mental health. Traditional Chinese Medicine provides new ideas and methods for treating hypertrophic scars with minimal side effects. Further research on botanical compounds and drug delivery systems can improve the quality and safety of botanical drugs for clinical applications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Wei Zhuang, Shao-Li Liu, Sheng-Yan Xi, Ying-Nan Feng, Ke Wang, Teliebald Abduwali, Ping Liu, Xiao-Jiang Zhou, Lan Zhang, Xian-Zhe Dong
Summary: This article summarizes the frequently used traditional Chinese medicine decoctions and Chinese patent medicines for treating depression, reviews their clinical therapeutic effects and possible mechanisms, and highlights the importance of traditional Chinese medicine in the management of depression.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Plant Sciences
Wei Peng, Nan Li, Ercheng Jiang, Chao Zhang, Yongliang Huang, Ling Tan, Ruyan Chen, Chunjie Wu, Qinwan Huang
Summary: This study provides a summary of traditional and current processing methods used to detoxify Pinellia ternata, with a focus on the processing mechanisms using adjuvants.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xin Shi, Yuhong Zheng, Li Fu
Summary: Electrochemical oscillation method plays a significant role in the qualitative and quantitative testing of traditional Chinese medicines, as it offers advantages in analyzing and processing complex components of herbal systems, and is helpful in quality control and identification.
APPLIED SCIENCES-BASEL
(2022)
Review
Pharmacology & Pharmacy
Xue Bai, Meng Zhang
Summary: Research has shown that traditional Chinese medicine has a clinical impact on vascular dementia, improving patients' cognitive function and quality of life. The pharmacological mechanisms of TCM for VD treatment include targeting the kidneys, eliminating turbidity, and promoting blood circulation, indicating promising prospects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Chao Mo, Jie Zhao, Jingyan Liang, Huiling Wang, Yu Chen, Guodong Huang
Summary: Exosomes play a crucial role in intercellular communication, and the interaction between exosomes and traditional Chinese medicine (TCM) has beneficial effects on various diseases. TCM formulas and compounds can modulate exosomes to inhibit cell proliferation, reduce inflammation, and attenuate fibrosis. Additionally, exosomes serve as a natural delivery system for TCM compounds, and they may also be potential biomarkers for TCM syndromes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Qi Zhang, Jianhang Zhou, Bob Zhang
Summary: This study systematically summarizes the development of computational TCM diagnosis, focusing on digital acquisition devices, collected datasets, and computational detection methods. It provides principles, applications, and current progress in computing for computational TCM diagnosis while discussing future development directions and technological trends.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Chien-Yu Ko, Jung Chao, Pei-Yu Chen, Shan-Yu Su, Tomoji Maeda, Chin-Yu Lin, Hung-Che Chiang, Shyh-Shyun Huang
Summary: The study investigated 74 skin whitening prescriptions sold in TCM pharmacies in Taiwan, revealing 90 traditional Chinese medicinal materials mainly sourced from Apiaceae and Leguminosae. Oral prescriptions were mostly warm and sweet, while external prescriptions included cold and bitter medicinal materials, with a focus on tonifying and replenishing effects. Pharmacological analysis indicated potential benefits for wound healing, inflammatory skin diseases, and anti-hyperpigmentation.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Wang Shao-Mei, Ye Li-Fang, Wang Li-Hong
Summary: Heart failure often stems from various cardiovascular diseases, with an energy metabolism disorder of cardiomyocytes serving as a molecular basis. Current drugs like ARNi and SGLT-2 inhibitors target myocardial metabolism to treat HF. Traditional Chinese medicine, including Danshen yin and Fufang Danshen dripping pill, has gained acceptance for HF treatment, potentially serving as a complementary approach for prevention.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Integrative & Complementary Medicine
Jillian L. Capodice, Barbara M. Chubak
Summary: Traditional Chinese Medicine (TCM) is a comprehensive medical system that has been developed over thousands of years and is utilized in the treatment of COVID-19. This paper highlights the use of TCM in treating COVID-19, discussing concepts and challenges of integrating TCM into medical settings.
Article
Biochemistry & Molecular Biology
Ping-Chung Kuo, Shih-Huang Tai, Ching-Che Hung, Tsong-Long Hwang, Liang-Mou Kuo, Sio Hong Lam, Kun-Ching Cheng, Daih-Huang Kuo, Hsin-Yi Hung, Tian-Shung Wu
Summary: A total of twelve undescribed lanostane-type triterpenes and twenty-two known triterpenes were isolated and identified from the medicinal bracket fungus Fomitopsis pinicola. Among the thirty-two triterpene compounds evaluated for antiinflammatory potential, pinicolasin J showed the highest potency as an inhibitor of superoxide anion generation and elastase release. This study contributes to the understanding of the nutritional and medicinal properties of Fomitopsis pinicola.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Shin-Hun Juang, Min-Tsang Hsieh, Pei-Ling Hsu, Ju-Ling Chen, Hui-Kang Liu, Fong-Pin Liang, Sheng-Chu Kuo, Chen-Yuan Chiu, Shing-Hwa Liu, Chen-Hsi Chou, Tian-Shung Wu, Hsin-Yi Hung
Summary: In the study, 6,7-diprenoxycoumarin was identified as the most effective CAR activator, with modifications at the 6 position and unsaturated chains generally beneficial. The research also indicated that mimicking natural occurring coumarins for modification shed light on CAR studies.
Article
Chemistry, Medicinal
Yi-Han Chang, Fang Shu-Yen, Hsuan-Yu Lai, Tsong-Long Hwang, Hsin-Yi Hung
Summary: The over activation of neutrophils has been linked to several inflammatory diseases, with the generation and release of superoxide anion being a critical pathologic mechanism. A compound, 2-(3,5-dimethoxyphenoxy)-5,7-dimethoxy-chromen-4-one, showed moderate inhibitory effect on superoxide anion generation, leading to the design and synthesis of chromones substituted with phenols or 3-flourothiophenol for suppression of superoxide anion generation. One successful example, 2-(3-fluorophenyl)sulfanyl-7-methoxy-chromen-4-one, exhibited significant anti-inflammatory effects with an IC50 value of 5.0 +/- 1.4 μM against superoxide anion generation.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Hsin-Yi Hung, Shih-Min Lin, Chia-Ying Li, Sio-Hong Lam, Yu-Yi Chan, Meei-Jen Liou, Po-Chuen Shieh, Fu-An Chen, Ping-Chung Kuo, Tian-Shung Wu
Summary: A highly specific and sensitive proton nuclear magnetic resonance method has been developed for the quantification of ephedrine alkaloid derivatives in Ephedra herbal commercial prescriptions. This method allows for rapid and simple quantification without the need for preliminary purification steps and standard compounds, making it a powerful tool for verifying different Ephedra species.
Article
Biochemistry & Molecular Biology
Kun-Ching Cheng, Chin-Fu Chen, Chin-Chuan Hung, Sio-Hong Lam, Hsin-Yi Hung, Yue-Chiun Li, Fu-An Chen, Po-Chuen Shieh, Ping-Chung Kuo, Tian-Shung Wu
Summary: The study identified several undescribed compounds from Taiwanofungus salmoneus, some of which showed inhibitory effects on multidrug resistance and potential for cancer therapy.
BIOORGANIC CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Li-yun Zheng, Xi Zou, Yan-li Wang, Min Zou, Fang Ma, Ning Wang, Jia-wen Li, Ming-sheng Wang, Hsin-Yi Hung, Qiang Wang
Summary: Alcoholic abuse is a major cause of liver diseases globally, with oxidative stress being a critical factor. This study showed that BAN, a betulinic acid and nucleoside hybrid compound with good water solubility, effectively reversed acute alcohol-induced liver damages by reducing serum ALT level and liver oxidative stress. The protective role of BAN was mediated through hepatic FXR activation and the promotion of cellular autophagy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hsin-Yi Hung, Kun-Ching Cheng, Ping-Chung Kuo, I-Tsen Chen, Yue-Chiun Li, Tsong-Long Hwang, Sio-Hong Lam, Tian-Shung Wu
Summary: Seven new anthraquinones with rare functional moieties were isolated from the whole Hedyotis diffusa plants. These compounds exhibited potent anti-inflammatory activity and could be developed as lead compounds.
Article
Chemistry, Medicinal
Yi-Han Chang, Chia-Hung Yen, Chih-Chung Lai, Hsuan-Yu Lai, Hsin-Yi Hung
Summary: The population with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is increasing, and there is an urgent need to develop a new drug to overcome these diseases. Capillarisin and its related compounds were found to have protective effects against lipid droplet formation in liver cells. Compounds with trimethoxy groups on the phenyl ring showed better inhibitory properties, but some compounds exhibited cytotoxicity. Finally, an active compound was identified that reduced lipid droplet accumulation by up-regulating a specific protein, showing promise for managing NAFLD and NASH.
Article
Chemistry, Medicinal
Yi-Han Chang, Hsin-Yi Hung
Summary: Obesity is associated with an increased risk for various diseases and there is a lack of pharmaceutical choices. This article provides inspiration for the exploration of innovative anti-obesity agents by summarizing recent discoveries of natural anti-obesity compounds with in vivo evidence, and discusses medicinal chemistry achievements guided by natural sources.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Yi-Han Chang, Heng Lin, Hsiao-Fen Li, Hsi-Hsien Chen, Hsin-Yi Hung
Summary: The induction of activating transcription factor 3 (ATF3) shows promise as a therapeutic mechanism to overcome metabolic syndrome. A study conducted a structure-activity relationship campaign and identified achiral 16c as a potential ATF3 inducer with lipid-lowering effects. In animal experiments, mice treated with 16c showed significant weight loss, reduced white adipose mass, and improved glycemic profile compared to the chiral lead compound 1b. Additionally, 16c ameliorated liver function and improved the plasma triglyceride profile. Therefore, 16c could be further developed as an ATF3 stimulant to alleviate metabolic syndrome.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Poyu Chen, Hsin-Yi Hung, Joshua Oon Soo Goh
Summary: This study examines age-related differences in the temporal dynamics of neural processing in decision-making. Using a lottery-choice task and event-related potentials, the researchers found that younger adults showed greater P2 ERP-response positivity and later P3 positivity, which increased with win probability. Older adults displayed lower P2 responses and P3 amplitudes, with higher positivity for extreme win probabilities. Both age groups exhibited similar reward prediction error representations and salience integration. However, older adults showed more complex sensitivity to expectancy violations, indicating subjective uncertainty about reward expectations. The findings suggest that older adults' risk-taking behaviors may be influenced by reduced early neural processing of objective stimulus value and increased reliance on subjective processes.
NEUROBIOLOGY OF AGING
(2023)
Article
Biology
Wen-Te Liu, Huei-Tyng Huang, Hsin-Yi Hung, Shang-Yang Lin, Wen-Hua Hsu, Fang-Yu Lee, Yi-Chun Kuan, Yin-Tzu Lin, Chia-Rung Hsu, Marc Stettler, Chien-Ming Yang, Jieni Wang, Ping-Jung Duh, Kang-Yun Lee, Dean Wu, Hsin-Chien Lee, Jiunn-Horng Kang, Szu-Szu Lee, Hsiu-Jui Wong, Cheng-Yu Tsai, Arnab Majumdar
Summary: This study showed that continuous positive airway pressure (CPAP) treatment can alleviate symptoms of obstructive sleep apnea (OSA) and reduce the risk of neurodegenerative diseases. Both sleep quality scores and neurochemical biomarker levels significantly improved in patients treated with CPAP.
Article
Biotechnology & Applied Microbiology
Kishneth Palaniveloo, Kuan Hung Ong, Herland Satriawan, Shariza Abdul Razak, Suciati Suciati, Hsin-Yi Hung, Shin Hirayama, Mohammed Rizman-Idid, Jen Kit Tan, Yoong Soon Yong, Siew-Moi Phang
Summary: This study investigated the diversity of secondary metabolites and cholinesterase inhibiting potential for Alzheimer's disease (AD) in the red algae Laurencia snackeyi from Terumbu Island, Malaysia. Two compounds were identified with the best inhibitory properties. However, obtaining sufficient biomass for detailed investigation remains a challenge.
Article
Biochemistry & Molecular Biology
Yue-Chiun Li, Chia-Hung Wu, Thi Ha Le, Qingjun Yuan, Luqi Huang, Guo-Fen Chen, Mei-Lin Yang, Sio-Hong Lam, Hsin-Yi Hung, Handong Sun, Yi-Hung Wu, Ping-Chung Kuo, Tian-Shung Wu
Summary: A specific H-1-NMR method has been modified to quantify ephedrine alkaloids. Benzene was identified as the better extraction solvent to eliminate impurities. The locations of ephedrine alkaloids were confirmed using 2D NMR, and the concentrations of ephedrine and pseudoephedrine varied greatly among different species and collection locations of Ephedra plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ko-Hua Yu, Chan-Yen Kuo, I-Ting Wu, Ching-Ho Chi, Keng-Chang Tsai, Ping-Chung Kuo, Jing-Wen Zeng, Chin-Chuan Hung, Hsin-Yi Hung
Summary: Multidrug resistance is a significant challenge in cancer chemotherapy, but arctigenin derivatives show potential in reversing this resistance, especially when combined with paclitaxel.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
