Journal
CLINICAL JOURNAL OF GASTROENTEROLOGY
Volume 15, Issue 4, Pages 791-795Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12328-022-01654-0
Keywords
COVID-19; Autoimmune hepatitis; Hepatitis C; SARS-CoV-2; Vaccination
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This case report describes a patient who developed autoimmune hepatitis after receiving the COVID-19 vaccine. The patient had a history of HCV treatment but tested negative for HCV infection in laboratory tests. Steroid treatment rapidly improved her liver function.
Although vaccines have been effective against the worldwide pandemic of Coronavirus Disease 19 (COVID-19), some case reports have described autoimmune hepatitis triggered by COVID-19 vaccination. Meanwhile, hepatitis C virus (HCV) is known to be related to autoimmune diseases. Here, we report a case of autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination. An 82-year-old woman was referred to our hospital for severe liver injury. She had received a COVID-19 vaccination 7 days prior. She had a history of HCV treatment with direct-acting antivirals 7 years previously. In her blood data, despite HCV antibody positivity, she was negative for HCV RNA by real-time RT-PCR. Anti-nuclear antibody was positive and IgG was elevated. Interface hepatitis and plasma cell infiltration were confirmed pathologically. She was diagnosed as autoimmune hepatitis and her liver injury quickly improved after initiation of steroid administration. This is a first case report of autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination.
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