Journal
JOURNAL OF FLUORESCENCE
Volume 26, Issue 3, Pages 1101-1113Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10895-016-1800-9
Keywords
Ru(II) polypyridyl complexes; DNA binding; Photocleavage; Antimicrobial activity; In vitro cytotoxicity
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The four novel Ru(II) polypyridyl complexes of [Ru(Hdpa)(2)dmbip](2+) (1), [Ru(Hdpa)(2)NO2-dmbip](2+) (2), [Ru(Hdpa)(2)debip](2+) (3) and [Ru(Hdpa)(2)OH-debip](2+) (4) where Hdpa = 2,2'-bipyridylamine, dmbip = 2-(4-N,N-dimethylbenzenamine)1H-imidazo[4,5-f][1,10]phenanthroline, debip = 2-(4-N,N-diethylbenzenamine)1H-imidazo[4,5-f][1,10]phenanthroline, NO2-dmbip = NO(2-)2-(4-N,N-dimethylbenzenamine)1H-imidazo[4,5-f][1,10]phenanthroline, OH-debip = OH-2-(4-N,N-diethylbenzenamine)1H-imidazo[4,5-f][1,10]phenanthroline were synthesized and fully characterized using elemental analysis, Mass, NMR and FT-IR. The DNA binding behavior of all synthesized complexes were investigated by using electronic absorption spectra, emission spectra, cyclic light switch on and off, sensor studies, electrochemical method and viscosity titrations. Docking studies were performed with human DNA TOP1 by using LibDock. Furthermore explore antimicrobial activity, photocleavage and in vitro cytotoxicity assay of four Ru(II) complexes.
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