ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1

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Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis

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Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor

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Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system

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Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

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SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development

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JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships

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Suppressor of Fused Chaperones Gli Proteins To Generate Transcriptional Responses to Sonic Hedgehog Signaling

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Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions

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Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

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RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors

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Two Hydrophobic Residues Can Determine the Specificity of Mitogen-activated Protein Kinase Docking Interactions

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Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases

(2015) A. Zeke et al.   Molecular Systems Biology

A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response

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Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction

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Mitogen-activated protein kinases and Hedgehog-GLI signaling in cancer: A crosstalk providing therapeutic opportunities?

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Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1

(2015) Philipp Schneider et al.   Nature Communications

AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma

(2015) Yen-Hsing Li et al.   Cell Reports

Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization

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Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling

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Germline Mutations inSUFUCause Gorlin Syndrome–Associated Childhood Medulloblastoma and Redefine the Risk Associated WithPTCH1Mutations

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Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

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Targeting RAS–ERK signalling in cancer: promises and challenges

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Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy

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Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

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Physicochemical mechanisms of protein regulation by phosphorylation

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Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulation

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Allostery in Disease and in Drug Discovery

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Decoding the phosphorylation code in Hedgehog signal transduction

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Combining docking site and phosphosite predictions to find new substrates: Identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate

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ERK as a Model for Systems Biology of Enzyme Kinetics in Cells

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Hedgehog Signaling Regulates Telomerase Reverse Transcriptase in Human Cancer Cells

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Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci

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Loss of SUFU Function in Familial Multiple Meningioma

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The Crosstalk of mTOR/S6K1 and Hedgehog Pathways

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Multisite Phosphorylation Disrupts Arginine-Glutamate Salt Bridge Networks Required for Binding of Cytoplasmic Linker-associated Protein 2 (CLASP2) to End-binding Protein 1 (EB1)

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Hedgehog pathway inhibition and the race against tumor evolution

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MEK1–RSK2 contributes to hedgehog signaling by stabilizing GLI2 transcription factor and inhibiting ubiquitination

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The Hedgehog Signal Transduction Network

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MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

Gli Proteins in Development and Disease

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A Mechanism for the Evolution of Phosphorylation Sites

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Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3β Regulates Its Stability and Localization in the Primary Cilium

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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

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A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

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Computational Prediction and Experimental Verification of New MAP Kinase Docking Sites and Substrates Including Gli Transcription Factors

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Identification of aSUFUgermline mutation in a family with Gorlin syndrome

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NCBI BLAST: a better web interface

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