Review
Cardiac & Cardiovascular Systems
Jiawen Li, Yulin Zhang, Donghui Zhang, Yifei Li
Summary: Sepsis-induced cardiac dysfunction (SICD) is a major cause of death in septic cases. Long non-coding RNAs (lncRNAs) have been identified as a novel opportunity to explore the mechanisms and development of SICD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Lei Shi, Peter Magee, Matteo Fassan, Sudhakar Sahoo, Hui Sun Leong, Dave Lee, Robert Sellers, Laura Brulle-Soumare, Stefano Cairo, Tiziana Monteverde, Stefano Volinia, Duncan D. Smith, Gianpiero Di Leva, Francesca Galuppini, Athanasios R. Paliouras, Kang Zeng, Raymond O'Keefe, Michela Garofalo
Summary: This study reveals the role of KIMAT1 in maintaining KRAS signaling in lung cancer progression, suggesting that targeting it may be a strategy to prevent KRAS-induced tumorigenesis.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Jihui Lee, Hara Kang
Summary: Sarcopenia is an age-related disease that can be regulated by alterations in the expression levels of non-coding RNAs, leading to muscle atrophy and dysfunction. Exercise can affect the expression patterns of non-coding RNAs involved in sarcopenia.
Article
Biochemistry & Molecular Biology
Ida Manna, Francesco Fortunato, Selene De Benedittis, Ilaria Sammarra, Gloria Bertoli, Angelo Labate, Antonio Gambardella
Summary: Temporal lobe epilepsy is the most common form of focal epilepsy, considered a network disorder associated with structural changes. Non-coding RNAs, acting as epigenetic factors, participate in the regulation of the pathophysiological processes of epilepsy and can be used as biomarkers for diagnosis and treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Zhaobo Zhang, Sishi Zhang, Guoshuai Wang, Siyu Feng, Kexin Han, Limei Han, Liping Han
Summary: Marek's disease virus (MDV) causes Marek's disease (MD), which involves highly infectious tumor lesions. Noncoding RNAs play a significant role in the pathogenesis of MD, with specific miRNAs and lncRNAs participating in various cellular processes.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Neurosciences
Changteng Zhang, Rui Gao, Ruihao Zhou, Hai Chen, Changliang Liu, Tao Zhu, Chan Chen
Summary: Chronic pain is a complex sensory and emotional experience lasting longer than 3 months, with altered genetic elements in CP patients and essential roles of non-coding RNAs in CP regulation. Multiple key ncRNAs have been identified in animal models, suggesting potential new therapeutic targets for CP.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Yang Liu, Xing Lyu, Shengy Tan, Xiangyu Zhang
Summary: This review summarizes the origins and functions of exosomes, as well as the role of exosomal non-coding RNAs in pathological cardiac remodeling.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Oncology
Yohann Dabi, Amelia Favier, Leo Razakamanantsoa, Stephane Suisse, Yannick Marie, Cyril Touboul, Clement Ferrier, Sofiane Bendifallah, Emile Darai
Summary: Cervical cancer (CC) is a major cause of cancer death in women, and accurate assessment of lymph node status is crucial for prognosis and treatment. Previous studies have suggested the potential value of non-coding RNA expression in CC. This review discusses the contribution of non-coding RNAs in tissue and biofluid samples to determine lymph node status in CC, with potential implications for surgical and adjuvant therapies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
C. E. Fletcher, L. Deng, F. Orafidiya, W. Yuan, M. P. G. S. Lorentzen, O. W. Cyran, A. Varela-Carver, T. A. Constantin, D. A. Leach, F. M. Dobbs, I Figueiredo, B. Gurel, E. Parkes, D. Bogdan, R. R. Pereira, S. G. Zhao, A. Neeb, F. Issa, J. Hester, H. Kudo, Y. Liu, Y. Philippou, R. Bristow, K. Knudsen, R. J. Bryant, F. Y. Feng, S. H. Reed, I. G. Mills, J. de Bono, C. L. Bevan
Summary: miR-346 induces rapid and extensive DNA damage in prostate cancer cells through transcriptional hyperactivation, R-loop formation, and replication stress. It disrupts the interaction between NORAD and PUM2, leading to PUM2 stabilization and increased turnover of DNA damage response transcripts. miR-346 downregulates target transcripts preferentially at binding sites of highly transcriptionally active transcription factors. Targeting miR-346 may enhance the sensitivity of prostate cancer cells to DNA-damaging drugs and induce tumor regression as a monotherapy.
Article
Multidisciplinary Sciences
Hongwei Yan, Qi Liu, Jieming Jiang, Xufang Shen, Lei Zhang, Zhen Yuan, Yumeng Wu, Ying Liu
Summary: This study utilized high-throughput sequencing to analyze the transcriptome of tiger pufferfish gonads, identifying numerous miRNAs and lncRNAs potentially involved in regulating sex-related gene expression. Differential expression analysis revealed specific miRNAs and lncRNAs that were up-regulated or down-regulated in male gonads compared to female gonads. These findings could lead to further research on the function of miRNAs and lncRNAs in sex determination and differentiation.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Hongxu Li, Jie Gao, Long Liu, Shuijun Zhang
Summary: LINC00958, a long non-coding RNA highly expressed in various malignancies, plays a role in enhancing tumor cells' resistance to radiotherapy and chemotherapy, inducing lymphangiogenesis, and facilitating tumor glycolytic metabolism. Additionally, LINC00958 acts as a ceRNA and regulates the malignant behavior of tumor cells through the miRNA-mRNA axis, showcasing potential as a novel biomarker and therapeutic target in cancer diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Veterinary Sciences
Yan Zhang, Meijin Wu, Jiahao Zhou, Hongxiu Diao
Summary: Research shows that lncRNA plays a crucial role in canine tumors and has the potential to be a biomarker for diagnosing, monitoring, and treating tumors. Further research on the function and mechanism of lncRNA is of great importance to both human and veterinary medicine.
VETERINARY SCIENCES
(2023)
Article
Medicine, Research & Experimental
Mingxing Li, Xiao Yu, Qingyuan Zheng, Qiyao Zhang, Yuting He, Wenzhi Guo
Summary: Long non-coding RNAs (lncRNAs) are a newly identified class of RNA molecules at least 200 nucleotides in length that are not translated into proteins. The lncRNA prostate cancer-associated transcript 6 (PCAT6) is upregulated in various human malignancies and is closely correlated with aggressive clinicopathological characteristics and poor prognosis in cancer patients, indicating it is an oncogenic lncRNA that could serve as a new prognostic biomarker and therapeutic target for malignancies. The molecular mechanisms, regulatory functions, and potential clinical applications of PCAT6 in cancer are discussed.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Jin Li, Ane M. Salvador, Guoping Li, Nedyalka Valkov, Olivia Ziegler, Ashish Yeri, Chun Yang Xiao, Bessie Meechoovet, Eric Alsop, Rodosthenis S. Rodosthenous, Piyusha Kundu, Tianxiao Huan, Daniel Levy, John Tigges, Alexander R. Pico, Ionita Ghiran, Michael G. Silverman, Xiangmin Meng, Robert Kitchen, Jiahong Xu, Kendall Van Keuren-Jensen, Ravi Shah, Junjie Xiao, Saumya Das
Summary: miR-30d can improve cardiac function and reduce fibrosis by targeting MAP4K4 and integrin alpha 5, showing a protective effect in ischemic heart failure. The communication of extracellular vesicle-contained miRNAs may provide a novel therapeutic target in heart failure treatment.
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Anshika Goenka, Deanna Marie Tiek, Xiao Song, Rebeca Piatniczka Iglesia, Minghui Lu, Bo Hu, Shi-Yuan Cheng
Summary: Research in cancer biology has predominantly focused on protein-coding genes, but the discovery of non-coding RNAs (ncRNAs) has shed light on their crucial role in various biological processes and human diseases including cancer. Dysregulated ncRNA expression affects cancer initiation, progression, and therapy resistance. This review emphasizes the recent developments and advances in ncRNA biology relevant to glioma tumorigenesis and therapy response, highlighting the potential of ncRNAs as biomarkers and therapeutic agents in glioma.
