Article
Dentistry, Oral Surgery & Medicine
Ju-Bin Lee, Min-Seock Seo
Summary: This study evaluated the root canal configurations of mandibular first molars and their association with the distolingual root (DLR) and mandibular incisors using CBCT. The findings showed a high incidence of separate DLRs in mandibular first molars. It was also confirmed that the presence of DLR in the mandibular first molar is highly associated with the presence of a two-canal system in the mandibular incisors.
Review
Dentistry, Oral Surgery & Medicine
Julieta Sarai Becerra-Ruiz, Celia Guerrero-Velazquez, Fernando Martinez-Esquivias, Luz Andrea Martinez-Perez, Juan Manuel Guzman-Flores
Summary: Periodontal disease, characterized by inflammation of tooth-supporting tissues, has a multifactorial etiology. Host immune response is crucial in defending against microorganisms, but bacterial persistence and immune system dysregulation can worsen the disease. Understanding cellular mechanisms involved in periodontal disease development is essential for designing new treatments and preventive measures to reduce its global prevalence.
Article
Anatomy & Morphology
Guido Sampermans, Alexander Sawaljanow, Peter Proff, Christian Kirschneck, Eva Paddenberg
Summary: This retrospective study analyzed the alveolar bone thickness at the buccal and oral roots of the first mandibular molars in the general population using CBCT scans. The study found significant local and gender-specific differences in bone thickness, with women showing thicker bone in certain areas. The results have important implications for assessing the ideal transverse molar position.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2022)
Article
Immunology
Wenmin Zeng, Guojing Liu, Qingxian Luan, Chunyu Yang, Shiyi Li, Xiaoqian Yu, Li Su
Summary: B-cell deficiency exacerbates inflammation and alveolar bone loss in ligature-induced experimental periodontitis in mice, suggesting a role for B cells in the initiation of periodontitis. This is associated with increased osteoclast activity, upregulated RANKL expression, and a shift in gingiva cytokine expression profiles to Th1 and Th17. Additionally, a reduced CD4(+)/CD8(+) T cell ratio was observed in the B cell-deficient mice.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Fernando Oliveira Costa, Jose Roberto Cortelli, Sheila Cavalca Cortelli, Amanda Almeida Costa, Rafael Paschoal Esteves Lima, Adriana Moreira Costa, Gustavo Henrique Mattos Pereira, Luis Otavio Miranda Cota
Summary: The aim of this study was to assess the impact of furcation involvement on the longevity of molars and identify the risk variables associated with molar loss in individuals receiving supportive periodontal care. The study found that patient-related factors such as age, gender, diabetes, and smoking, as well as tooth-related factors like tooth vitality and periodontal parameters, significantly influenced the prognosis of molars.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Pengfei Zhao, Aimin Xu, Wai Keung Leung
Summary: Obesity and periodontitis are common health concerns with negative relationships. Obesity leads to bone metabolic disorders and increased risks of periodontitis and alveolar bone loss. This review summarizes the clinical changes in periodontium and the biological interlinks in obesity-associated bone remodeling. The potential mechanism underlying obesity-enhanced alveolar bone loss is also discussed, providing practical considerations for managing periodontal disease in obese patients.
Article
Medicine, General & Internal
Huiyi Hong, Jing Zhou, Qi Fan, Ruijie Jiao, Qianyun Kuang, Hong Zhou, Chengge Hua, Zheng Yang, Wenli Lai, Hu Long
Summary: This cross-sectional study investigated the spatial changes in molars and alveolar bone resorption among patients with loss of mandibular first molars. The results showed significant reductions in both alveolar bone height and width, as well as mesial and lingual tipping of the mandibular second molars. The duration of tooth loss was significantly correlated with the angulation of the teeth and the extrusion of the maxillary first molar. Bone augmentation is indicated for severely resorbed alveolar bone.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Yun Jeong Lee, Hyeran Helen Jeon, Normand Boucher, Chun-Hsi Chung
Summary: This study aimed to assess the buccolingual inclination of mandibular first molars and their alveolar bones and their relationship with different vertical facial types. The results showed a significant correlation between the inclination of the tooth and alveolar bone, but no significant correlation between the inclination of alveolar bone and vertical facial types. This study supports the importance of maintaining a proper curve of Wilson during orthodontic treatment.
APPLIED SCIENCES-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Aline Leite de Farias, Diego Fernando Rojas-Gualdron, Diego Girotto Bussaneli, Lourdes Santos-Pinto, Juan Diego Mejia, Manuel Restrepo
Summary: This study explored the association between MIH and enamel hypomineralization of the second permanent molars. Severe defects in first permanent molars were linked to mild defects in the second permanent molars, and enamel hypomineralization was associated with increased caries experience.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zhuo-Lin Kong, Ge-Ge Wang, Xue-Ying Liu, Zhang-Yan Ye, Dong-Qian Xu, Xi Ding
Summary: The study used CBCT data to investigate the anatomical relationship between the mandibular molar and alveolar bone for the design of implant restoration. Results showed no significant differences in morphology between the left and right lower first molars, with morphology classified into straight, oblique, and concave types. The proposed classification provides evidence for appropriate selection and design of mandibular molar implants, with the concave type posing the highest risk of lingual perforation.
Article
Chemistry, Multidisciplinary
Ho Sun Shon, Vungsovanreach Kong, Jae Sung Park, Wooyeong Jang, Eun Jong Cha, Sang-Yup Kim, Eun-Young Lee, Tae-Geon Kang, Kyung Ah Kim
Summary: In this study, a deep learning framework was developed for classifying the periodontitis stages using dental panoramic radiographs. The framework showed a relatively high level of classification performance when compared to dental specialists. It is expected to assist dental specialists in detecting the periodontitis stage and providing effective treatment.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Biomedical
Lu Wang, Yuzhou Li, Mingxing Ren, Xu Wang, Lingjie Li, Fengyi Liu, Yiqing Lan, Sheng Yang, Jinlin Song
Summary: This study designed a novel dual responsive and dual drug-loading nanocarrier system for precise and controlled drug delivery to treat periodontitis in patients with diabetes. In vitro and in vivo studies confirmed the effectiveness of this nanocarrier, which can inhibit the formation of subgingival microbial colonies and promote osteogenic differentiation of cells, ameliorating periodontal bone resorption.
BIOACTIVE MATERIALS
(2022)
Article
Immunology
Fuhua Yang, Yifei Zhang, Zhi Chen, Lu Zhang
Summary: VISTA is upregulated in inflammatory tissues of apical periodontitis, acting as a negative regulator to suppress inflammation and bone loss.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Fengzhen Lei, Mujia Li, Tingting Lin, Hong Zhou, Fei Wang, Xiaoxia Su
Summary: Exosomes secreted by healthy periodontal ligament stem cells (PDLSCs) promote osteogenic differentiation of PDLSCs derived from periodontitis tissue. Treatment with exosomes can accelerate bone formation in rat models of periodontitis. Mechanistically, exosomes suppress over-activation of the canonical Wnt signaling pathway to recover the osteogenic differentiation capacity of inflammatory PDLSCs. These findings suggest that MSC-derived exosomes are an effective and practical cell-free therapeutic for the treatment of periodontitis.
ACTA BIOMATERIALIA
(2022)
Article
Dentistry, Oral Surgery & Medicine
J. Zhang, L. Sun, M. H. H. Withanage, S. M. Ganesan, M. A. Williamson, J. T. Marchesan, Y. Jiao, F. R. Teles, N. Yu, Y. Liu, D. Wu, K. L. Moss, A. K. Mangalam, E. Zeng, Y. L. Lei, S. Zhang
Summary: This study identified a risk locus TRAF3IP2 associated with periodontitis and investigated its underlying mechanism in the development of periodontitis. The results showed that TRAF3IP2 plays a significant role in the production of chemokines mediated by IL-17 and in host defense against periodontal pathogens.
JOURNAL OF DENTAL RESEARCH
(2023)