Article
Biochemistry & Molecular Biology
Jovana Kabic, Katarina Novovic, Dusan Kekic, Anika Trudic, Natasa Opavski, Ivica Dimkic, Branko Jovcic, Ina Gajic
Summary: This study aimed to investigate the prevalence and resistance mechanisms of colistin-resistant Acinetobacter baumannii (ColRAB) isolates in Serbia, assess their genetic relatedness to other circulating A. baumannii isolates in the neighbouring European countries, and analyse the global genomic epidemiology of ColRAB isolates. The findings reveal the central role of the twocomponent regulating system, PmrAB, and increased expression of the pmrC gene in colistin resistance in A. baumannii. The study also highlights the global dissemination of several high-risk clonal lineages of ColRAB isolates.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Microbiology
Karyne Rangel, Thiago Pavoni Gomes Chagas, Salvatore Giovanni De-Simone
Summary: The COVID-19 pandemic has led to overuse of antimicrobials in critically ill patients, increasing the incidence of pathogens like Acinetobacter baumannii in ICUs. Patients with COVID-19 are at risk of secondary bacterial infections due to comorbidities and immune dysfunction.
Article
Infectious Diseases
Bernardetta Segatore, Alessandra Piccirilli, Sabrina Cherubini, Luigi Principe, Giovanni Alloggia, Maria Lina Mezzatesta, Mario Salmeri, Stefano Di Bella, Roberta Migliavacca, Aurora Piazza, Elisa Meroni, Paolo Fazii, Daniela Visaggio, Paolo Visca, Venere Cortazzo, Giulia De Angelis, Arianna Pompilio, Mariagrazia Perilli
Summary: The in vitro activity of the sulbactam-durlobactam (SUL-DUR) combination was evaluated against carbapenem-resistant A. baumannii (CRAb) clinical strains collected from multiple regions in Italy. The combination showed effectiveness against most isolates, with only a few exhibiting resistance due to the presence of additional resistance genes and mutations. The isolates also showed the presence of multidrug efflux pump genes associated with multidrug resistance.
Article
Infectious Diseases
T. Kostyanev, B. B. Xavier, M. Garcia-Castillo, C. Lammens, J. Bravo-Ferrer Acosta, J. Rodriguez-Bano, R. Canton, Y. Glupczynski, H. Goossens
Summary: This study investigated the phenotypic and molecular characteristics of carbapenem-resistant Acinetobacter baumannii isolates from the EURECA clinical trial. The isolates mainly harbored bla(OXA-23) or blaOXA-72 genes, with the majority belonging to international clone II and showing high diversity.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Infectious Diseases
Itziar Chapartegui-Gonzalez, Maria Lazaro-Diez, Santiago Redondo-Salvo, Jesus Navas, Jose Ramos-Vivas
Summary: Acinetobacter baumannii, a clinically relevant human pathogen belonging to the ESKAPE group, is known for its intrinsic multidrug resistance and ability to acquire new resistant determinants. Genomic analysis has provided insights into the microevolution of this pathogen and its antibiotic resistance mechanisms.
Article
Infectious Diseases
Nalumon Thadtapong, Soraya Chaturongakul, Sunhapas Soodvilai, Padungsri Dubbs
Summary: This study focused on analyzing the whole genome data of Aci46, and found that it belongs to the Pasture ST2 cluster and is phylogenetically clustered with the international clone (IC) II, a predominant strain in Thailand. Interestingly, Aci46 is identical to Oxford ST1962, which has never been isolated in Thailand before. The presence of potential virulence-associated factors and antibiotic resistance phenotypes were explored in the study.
Article
Infectious Diseases
Frank Hansen, Lone Jannok Porsbo, Tove Havnhoj Frandsen, Ayse Nur San Kaygisiz, Louise Roer, Anna E. Henius, Barbara Juliane Holzknecht, Lillian Soes, Kristian Schonning, Bent L. Roder, Ulrik S. Justesen, Claus ostergaard, Esad Dzajic, Mikala Wang, Nina Ank, Paul G. Higgins, Henrik Hasman, Anette M. Hammerum
Summary: This study used whole genome sequencing (WGS) to characterize carbapenemase-producing Acinetobacter baumannii isolates from Danish patients. The study compared typing and epidemiological data to investigate the spread and origin of these isolates. The results showed that most of the isolates belonged to the international clone IC2 and the most prevalent carbapenemase gene was bla OXA-23. The study confirmed sporadic and travel-related introductions of these isolates to Danish hospitals, highlighting the need for continued vigilance.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Microbiology
Ioannis Andrianopoulos, Theodora Maniatopoulou, Nikolaos Lagos, Nikolaos Kazakos, Athanasios Papathanasiou, Georgios Papathanakos, Despoina Koulenti, Christos Kittas, Vasilios Koulouras
Summary: COVID-19 patients with A. baumannii BSI have similar clinical characteristics and outcomes compared to non-COVID-19 patients, but COVID-19 patients are more likely to develop severe infections and septic shock, with ventilator-associated pneumonia as the main source of their BSI.
Article
Microbiology
Ghazal Naderi, Mahla Asadian, Pegah Afarinesh Khaki, Mohammadreza Salehi, Alireza Abdollahi, Masoumeh Douraghi
Summary: This study aimed to determine the occurrence of Acinetobacter baumannii genomic resistance islands (AbGRIs) in GC2 A. baumannii obtained from COVID-19 patients in a referral hospital in Tehran, Iran. PCR and sequencing were performed to characterize the structure of AbGRI resistance islands in the tested isolates. The results showed that AbGRI3 was the most frequent resistance island detected, followed by AbGRI1 and AbGRI2. Notably, AbGRIs were also identified in a strain of A. baumannii isolated from a medical device used in the ICU.
Article
Infectious Diseases
Samira M. Hamed, Walid F. Elkhatib, Hanka Brangsch, Ahmed S. Gesraha, Shawky Moustafa, Dalia F. Khater, Mathias W. Pletz, Lisa D. Sprague, Heinrich Neubauer, Gamal Wareth
Summary: The genomic epidemiology and resistome structure of 46 A. baumannii clinical isolates were studied, revealing the extensive presence of resistance genes and their distribution among different global clones (GCs) in Egypt. This data is crucial for understanding A. baumannii infections and the dissemination of resistance genes.
Article
Infectious Diseases
Andrey Shelenkov, Yulia Mikhaylova, Lyudmila Petrova, Irina Gaidukova, Mikhail Zamyatin, Vasiliy Akimkin
Summary: The COVID-19 pandemic has impacted bacterial antimicrobial resistance and population structures in healthcare facilities, requiring detailed epidemiological investigations for confirmation. A study in Moscow's COVID-19 ICU characterized multidrug-resistant A. baumannii isolates, revealing genomic similarity with previously identified clones in the same facility.
Article
Immunology
Nannan Wu, Jia Dai, Mingquan Guo, Jianhui Li, Xin Zhou, Feng Li, Yuan Gao, Hongping Qu, Hongzhou Lu, Jing Jin, Tao Li, Lei Shi, Qingguo Wu, Ruoming Tan, Mingli Zhu, Lan Yang, Yun Ling, Shunpeng Xing, Jianzhong Zhang, Bangxin Yao, Shuai Le, Jingmin Gu, Jinhong Qin, Jie Li, Mengjun Cheng, Demeng Tan, Linlin Li, Yiyuan Zhang, Zhaoqin Zhu, Jinfeng Cai, Zhigang Song, Xiaokui Guo, Li-Kuang Chen, Tongyu Zhu
Summary: This study investigated the efficacy of phage therapy in treating secondary bacterial infections in COVID-19 patients. The results showed that phages were able to reduce the burden of CRAB infections, indicating their potential in responding to secondary outbreaks in COVID-19 patients.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Infectious Diseases
Alessandro Russo, Francesca Gavaruzzi, Giancarlo Ceccarelli, Cristian Borrazzo, Alessandra Oliva, Francesco Alessandri, Eugenia Magnanimi, Francesco Pugliese, Mario Venditti
Summary: Our study found that COVID-19 patients exhibited higher occurrences of serum lactate levels mmol/l > 2, Acinetobacter baumannii colonization, BSI, and steroid therapy. Cox regression analysis demonstrated that serum lactate levels > 2 mmol/l, Acinetobacter baumannii colonization, BSI, and steroid therapy were associated with 30-day mortality. Additionally, factors independently associated with the development of BSI in COVID-19 patients included white blood cells count > 11,000 mm(3), serum lactate levels > 2 mmol/l, infections at time of ICU admission, Acinetobacter baumannii colonization, and steroid therapy.
Article
Medicine, General & Internal
Giorgia Montrucchio, Silvia Corcione, Tommaso Lupia, Nour Shbaklo, Carlo Olivieri, Miriam Poggioli, Aline Pagni, Davide Colombo, Agostino Roasio, Stefano Bosso, Fabrizio Racca, Valeria Bonato, Francesco Della Corte, Stefania Guido, Andrea Della Selva, Enrico Ravera, Nicoletta Barzaghi, Martina Cerrano, Pietro Caironi, Giacomo Berta, Cecilia Casalini, Bruno Scapino, Michele Grio, Massimiliano Parlanti Garbero, Gabriella Buono, Federico Finessi, Simona Erbetta, Paola Federica Sciacca, Gilberto Fiore, Alessandro Cerutti, Sergio Livigni, Daniela Silengo, Fulvio Agostini, Maurizio Berardino, Mauro Navarra, Silvia Vendramin, Enzo Castenetto, Marco Maria Liccardi, Emilpaolo Manno, Luca Brazzi, Francesco Giuseppe De Rosa
Summary: This study investigated the characteristics of COVID-19 ICU patients developing CR-Ab colonization/infection and evaluated mortality risk factors. The results showed a 19% positivity rate for CR-Ab in ICU patients and a 64.7% ICU mortality rate. Deceased patients had higher disease severity scores, and risk factors for invasive infections included extracorporeal membrane oxygenation, septic shock, and elderly age. Additionally, being colonized by CR-Ab was significantly associated with a higher risk of developing invasive infections, while colonized patients without infection had a higher survival rate.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Emina Pustijanac, Jasna Hrenovic, Mirna Vranic-Ladavac, Martina Mocenic, Natalie Karcic, Lorena Lazaric Stefanovic, Irena Hrstic, Jasenka Loncaric, Martina Seruga Music, Marina Drcelic, Dijana Majstorovic, Ines Kovacic
Summary: The aim of this study was to identify the source of Acinetobacter baumannii in the ICU after a COVID-19 outbreak, as it was not found on usually screened surfaces. A single A. baumannii isolate was recovered from the air conditioner and compared to clinical isolates from patients. Molecular and antibiotic resistance analysis confirmed that the isolate from the air conditioner was the same strain as those from patients. The study highlights the importance of disinfecting hospital air conditioners to prevent A. baumannii outbreaks.
